Effect of electrode geometry on the electrolyte resistance measurement over the surface of a skin phantom in a noninvasive manner

Delgado-Arenas, Humberto F.; Rodríguez-López, A.; Rivera, Fernando F.; Ramos, Karen J.; Reséndiz-Ramírez, Rubí; Antaño-López, R.

doi:10.1016/j.bioelechem.2019.107337

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…As described in the previous section, we suppose that this difference in reproducibility of the calibration curve stems from the current distribution and surface condition of the electrode. The uniform current distribution on the well-ordered surface of the PPE provides constant calibration curves, whereas the highly concentrated current on the disordered edge corner of the IDE can cause unstable profiles . The results clearly demonstrate that the PPE is more favorable in sensor applications than the IDE.…”

Section: Resultsmentioning

confidence: 86%

“…The uniform current distribution on the well-ordered surface of the PPE provides constant calibration curves, whereas the highly concentrated current on the disordered edge corner of the IDE can cause unstable profiles. 39 The results clearly demonstrate that the PPE is more favorable in sensor applications than the IDE. Selectivity of the IgG Sensor.…”

Section: ■ Results and Discussionmentioning

confidence: 87%

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Toward a Practical Impedimetric Biosensor: A Micro-Gap Parallel Plate Electrode Structure That Suppresses Unexpected Device-to-Device Variations

Honda

Kusaka

et al. 2022

ACS Omega

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We propose a rational electrode design concept for affinity biosensors based on electrochemical impedance spectroscopy to substantially suppress unexpected device-to-device variations. On the basis that the uniformity of the current distribution affects the variation, a novel micro-gap parallel plate electrode (PPE) was developed, where two planar electrodes with edges covered with a SiO 2 layer were placed face to face. The structure provides a uniform current distribution over the planar electrode surface and maximizes the contribution of the planar electrode surface to sensing. For a comparative study, we also fabricated a micro-structured interdigitated electrode (IDE) that has been widely adopted for high-sensitivity measurement, although its current is highly concentrated on the electrode edge corner. Protein G (PrG) molecules were immobilized on both electrodes to prepare an immunoglobulin G (IgG) biosensor on which the specific binding of PrG–IgG can occur. We demonstrated that the IgG sensor with the PPE has small device-to-device variations, in strong contrast to the sensor with the IDE having large device-to-device variations. The results indicate that the current distribution on the electrode surface is important to fabricating electrochemical impedance spectroscopy biosensors with small device-to-device variations. Furthermore, it was found that the PPE allows ultrasensitive detection, that is, the sensor exhibited a linear range from 1 × 10 –13 to 1 × 10 –7 mol/L with a detection limit of 1 × 10 –14 mol/L, which is a record sensitivity at low concentrations for EIS-based IgG sensors.

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Section: Resultsmentioning

confidence: 86%

Section: ■ Results and Discussionmentioning

confidence: 87%