Effect of early treatment with captopril and metoprolol singly and together on postinfarction left ventricular remodeling

Ricci, Roberto; Coletta, Claudio; Ceci, Vincenzo; Pajes, Giuseppe; Putini, Rita Lucia; Salustri, Alessandro; Bottero, G; Pasquale, Massimo

doi:10.1067/mhj.2001.117966

Cited by 13 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of metoprolol on improving electrical remodeling after MI is well verified by previous studies [32,33,34]. The present study demonstrated that metoprolol could reduce the transmural dispersion of ventricular repolarization at the IBZ.…”

Section: Discussionsupporting

confidence: 74%

Effects of Metoprolol on Sympathetic Remodeling and Electrical Remodeling at Infarcted Border Zone after Myocardial Infarction in Rabbits

Jiang

Lu²,

Yu³

et al. 2006

Cardiology

View full text Add to dashboard Cite

Background: The findings of sympathetic remodeling and its electrophysiological implications force us to rerecognize the drugs presently used. The aim of this study was toinvestigate the effects of metoprolol on sympathetic remodeling and electrical remodeling at the infarcted border zone (IBZ) after myocardial infarction (MI). Methods: Forty rabbits were randomly assigned into two groups: MI group (n = 20), ligation of the anterior descending coronary; Metoprolol group (n = 20), ligation of the anterior descending coronary and administration of oral metoprolol 5 mg/kg/day. Eight weeks after surgery, transmural dispersion of repolarization (TDR) at baseline, TDR and difference of TDR (ΔTDR) during sympathetic nerve stimulation were measured at the IBZ. The distribution and densities of growth associated protein 43 and tyrosine hydroxylase positive nerves at the IBZ were detected with immunohistochemical techniques. Results: The study was completed in the 36 surviving animals (18 rabbits in each group). The densities of growth associated protein 43 and tyrosine hydroxylase positive nerves in the Metoprolol group (2,550 ± 554 and 1,779 ± 458 µm²/mm², respectively) were lower than in the MI group (3,217 ± 589 and 2,616 ± 528 µm²/mm², respectively; both p < 0.01). TDR at baseline, TDR and ΔTDR during sympathetic nerve stimulation were shorter in the Metoprolol group than in the MI group (p < 0.01 for all). Conclusion: Metoprolol can inhibit sympathetic remodeling and electrical remodeling at the IBZ after MI. The association of metoprolol with improved electrical remodeling may be partly related to the inhibition of sympathetic remodeling.

show abstract

Section: Discussionsupporting

confidence: 74%

Effects of Metoprolol on Sympathetic Remodeling and Electrical Remodeling at Infarcted Border Zone after Myocardial Infarction in Rabbits

Jiang

Lu²,

Yu³

et al. 2006

Cardiology

View full text Add to dashboard Cite

show abstract

“…The possible reasons for this are that the cardioprotective mechanisms of metoprolol are achieved mainly by blocking cardiac β 1-receptors and thereby slowing heart rate and reduction in myocardial contractility and myocardial oxygen consumption. Compared with other beta-Blockers and angiotensin converting enzyme inhibitors (ACEI), the effect of metoprolol on preventing left ventricular remodeling is relatively weak [31, 32]. …”

Section: Discussionmentioning

confidence: 99%

Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction

Zhai²,

Zhang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Aim. To determine the effect of a Chinese herbal compound named Wenxin Granule on ventricular remodeling and myocardial apoptosis in rats with myocardial infarction (MI). Methods. Male Sprague-Dawley (SD) rats were randomly divided into four groups: the control group, the model group, the metoprolol group, and the Wenxin Granule group (WXKL group) with sample size (n) of 7 rats in each group. An MI model was established in all rats by occlusion of the left anterior descending coronary artery (the control group was without occlusion). Wenxin Granule (1.35 g/kg/day), metoprolol (12 mg/kg/day), and distilled water (5 mL/kg/day for the control and model groups) were administered orally for 4 weeks. Ultrasonic echocardiography was used to examine cardiac structural and functional parameters. Myocardial histopathological changes were observed using haematoxylin and eosin (H&E) dyeing. Myocardial apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining. Serum angiotensin II (Ang II) concentration was measured using the enzyme-linked immunosorbent assay (ELISA). Results. It was found that Wenxin Granule could partially reverse ventricular remodeling, improve heart function, alleviate the histopathological damage, inhibit myocardial apoptosis, and reduce Ang II concentration in rats with MI. Conclusions. The results of the current study suggest that Wenxin Granule may be a potential alternative and complementary medicine for the treatment of MI.

show abstract

“…In spite of these mechanisms, β-blockers favorably alter multiple outcomes in coronary artery disease beyond survival. These outcomes include decreasing infarct, decreasing left ventricular systolic and diastric volumes, decreasing arrhythmogenicity, and minimizing cardiac cytokine release and restenosis after percutaneous intervention [20, 21,23,24,25,26]. In addition, β-blockers have antiarrhythmic effects that may account for part of the mortality benefit [27].…”

Section: Discussionmentioning

confidence: 99%

β-Blocker Prescription and Outcomes in Hemodialysis Patients from The Japan Dialysis Outcomes and Practice Patterns Study

et al. 2009

View full text Add to dashboard Cite

Background/Aims: Given the clear benefits of mortality reduction observed for most β-blockers in clinical trials, they are relatively underused in hemodialysis patients. Since the outcomes associated with the use of β-blockers are not fully known, we investigated their effect on mortality among a cohort of hemodialysis patients. Methods: Data were analyzed from the Dialysis Outcomes and Practice Patterns Study phase II for 2,286 randomly selected patients on hemodialysis in Japan. Treatment with β-blockers was the major predictor variable. The main outcome measure was all-cause mortality. Cox regression analysis was used to assess an association between treatment with β-blockers and the risk of death. Results: 247 patients (11.9%) were administered β-blockers and 1,828 patients (88.1%) were not. Whereas patients treated with β-blockers had a higher prevalence of hypertension and coronary heart disease, Kaplan-Meier analysis revealed that all-cause mortality rates were significantly (p < 0.007) decreased in patients treated with β-blockers compared to those without. In multivariable, fully adjusted models, treatment with β-blockers was also independently associated with reduced all-cause mortality (hazard ratio = 0.48; p = 0.02). Conclusion: This study indicated a possible association between the use of β-blockers and reduced risk of mortality in hemodialysis patients. These results should be confirmed in further randomized controlled trials.

show abstract

Effect of early treatment with captopril and metoprolol singly and together on postinfarction left ventricular remodeling

Cited by 13 publications

References 35 publications

Effects of Metoprolol on Sympathetic Remodeling and Electrical Remodeling at Infarcted Border Zone after Myocardial Infarction in Rabbits

Effects of Metoprolol on Sympathetic Remodeling and Electrical Remodeling at Infarcted Border Zone after Myocardial Infarction in Rabbits

Effect of Wenxin Granule on Ventricular Remodeling and Myocardial Apoptosis in Rats with Myocardial Infarction

β-Blocker Prescription and Outcomes in Hemodialysis Patients from The Japan Dialysis Outcomes and Practice Patterns Study

Contact Info

Product

Resources

About