Effect of Early Thymectomy on Caries Incidence, Eating Pattern, and Masticatory Performance in Osborne-Mendel Strain Rats

Herzog, Eva; Just, Manfred; König, Klaus

doi:10.1177/00220345660450038201

Search citation statements

Order By: Relevance

Paper Sections

Select...

Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1968

1982

Publication Types

Select...

Article1

Book1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous report (18) examined caries incidence in rats that were thymectomized as neonates. No difference in the extent of caries a I, Immunized; SI, sham-immunized; NI, nonimmunized.…”

Section: Resultsmentioning

confidence: 99%

Effect of neonatal thymectomy on dental caries in rats

Ebersole¹,

Taubman²,

Smith³

1982

Infect Immun

View full text Add to dashboard Cite

The effect of T-cell depletion on susceptibility to dental caries after infection with Streptococcus mutans was studied. Rats were neonatally thymectomized (Tx) and infected with S. mutans 6715 or locally immunized with the homologous organism before infection. The Tx rats uniformly exhibited a higher level of infection with S. mutans and subsequently showed a greater extent of carious activity. Correlation studies were performed comparing the level of salivary and serum anti-S. mutans antibodies and the relative amount of dental caries. The results demonstrated that salivary immunoglobulin A antibody after immunization and infection, or infection only, showed a significant negative correlation with dental caries. Also, after local immunization, serum immunoglobulin G antibody showed a negative correlation with dental caries in the rats. These findings further support a major protective role for salivary immunoglobulin A in experimental dental caries in rats.

show abstract

“…A previous report (18) examined caries incidence in rats that were thymectomized as neonates. No difference in the extent of caries a I, Immunized; SI, sham-immunized; NI, nonimmunized.…”

Section: Resultsmentioning

confidence: 99%