Effect of early octreotide administration on the development of esophageal varices in cirrhotic rats

Ballas, Konstantinos; Tzioufa-Asimakopoulou, Valentine; Marakis, Georgios; Alatsakis, Michael; Papavasiliou, Athanassios V.; Rafailidis, S.; Sakadamis, Athanassios

doi:10.1016/j.hepres.2004.02.016

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…It is therefore understood why similar studies from various research centers often resulted in completely different conclusions [23][24][25][26][27] . This study was designed in order to avoid similar problems by directly investigating lower esophageal pathology as shown in a previous study conducted in our department, where early octreotide administration seemed to attenuate the development of esophageal varices in cirrhotic rats [9] . The submucosal vein plexus of the lower esophagus was therefore meticulously studied, and measurements were carefully performed with the aid of an image analysis system.…”

Section: Discussionmentioning

confidence: 99%

Early Propranolol Administration Does Not Prevent Development of Esophageal Varices in Cirrhotic Rats

Alatsakis

Ballas²,

Pavlidis³

et al. 2008

Eur Surg Res

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Background and Aims: Variceal bleeding is the most serious complication of portal hypertension associated with high mortality. This study was conducted to investigate any protective effect of early propranolol administration in the development and degree of esophageal varices in cirrhotic rats with portal hypertension. This topic is controversial in the literature. Methods: For the development of liver cirrhosis and esophageal varices, 60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein, followed by phenobarbital and carbon tetrachloride (CCl₄) administration. This operation enhances the development of cephalad collaterals, responsible for the induction of esophageal varices. After 2 weeks of CCl₄ administration, the rats were randomly separated into 2 groups. In group I, propranolol was continuously administered intragastrically throughout the study, whereas in group II normal saline (placebo) was administered instead. Cirrhosis was detected clinically by ascites development. Hemodynamic studies and morphometric analysis of the lower esophagus were performed after complete induction of cirrhosis, measuring the following parameters: portal pressure, total number of submucosal veins, total submucosal vessel area, mean cross-sectional submucosal vessel area, relative submucosal area (percentage) occupied by vessels and area of the single most dilated submucosal vein. Results: The statistical analysis revealed no statistically important difference between the 2 groups for the morphometrically studied parameters. However, portal venous pressure was lower in group I. Conclusion: Early propranolol administration did not protect rats from developing esophageal varices, despite the fact that a significant decrease in portal pressure was detected.

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Section: Discussionmentioning

confidence: 99%

Early Propranolol Administration Does Not Prevent Development of Esophageal Varices in Cirrhotic Rats

Alatsakis

Ballas²,

Pavlidis³

et al. 2008

Eur Surg Res

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“…Despite recent experimental studies, where rabbits have been used to induce cirrhosis by administration of CCl 4 and phenobarbital [18] , we have chosen Wistar rats because of their easiness in manipulation, as many other researchers agree [19][20][21] . All these studies were based on the model designed by Proctor and Chatamra [15] , which induces cirrhotic changes in rats, similar to human cirrhosis; furthermore, it ensures low mortality related to the method.…”

Section: Discussionmentioning

confidence: 99%

“…For the purpose of this work however, all animals failing to develop histopathologically satisfactory micronodular cirrhosis (about 5%) were excluded from the study. Animal body weight reflects the nutritional status of animals [15][16][17][18][19] , and that was found to be impaired, as a function of liver destruction. Mechanisms responsible for wound healing include approximation by shrinking and retraction, epithelialization and granulomatous tissue development.…”

Section: Discussionmentioning

confidence: 99%

“…Liver cirrhosis was induced by weekly intragastric administration of carbon tetrachloride (CCl 4 ) in the phenobarbital-induced rat, by using the model of Proctor and Chatamra [15] , as modified by others [16][17][18][19] for the calculation of the first and next weekly doses of CCl 4 . Briefly, phenobarbital (Kaneuron 5.4%, SERB), which is known to induce hepatic enzymes and expedite cirrhosis, was added to the drinking water of the animals at a dose of 35 mg/ dl, 14 days before the first administration of CCl 4 and continued to be given until the end of the experiment; animals had free access to phenobarbital-enriched water.…”

Section: Cirrhosis Modelmentioning

confidence: 99%

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Effect of Experimentally Induced Liver Cirrhosis on Wound Healing of the Post-Extraction Tooth Socket in Rats

Karalis¹,

Pavlidis²,

Psarras³

et al. 2007

Eur Surg Res

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Background: Wound healing in liver cirrhosis is known to be impaired possibly due to liver insufficiency and subsequent malnutrition status; however, there is no study to examine healing effectiveness of the tooth socket following an extraction in such patients. Materials and Methods: Irreversible cirrhosiswas induced in 30 Wistar rats by repetitive weekly doses of CCl₄ and continuous administration of phenobarbital in a 12-week course was monitored by body weight measurement and ascites development, and was proved histologically. One week later, cirrhotic and control rats were subjected to extractions of two maxillary grinders on each side, one side by simple method, the other by surgical method. Half of the animals of each subgroup were sacrificed on the 10th post-extraction day, whereas the other half on the 30th post-extraction day, and histological sections were examined from all tooth sockets for wound-healing activity. Results: A malnutrition status was detected in cirrhotic rats with significant difference in their body weight. Several histological parameters of socket healing were not statistically different between cirrhotic and control animals. However, a significant delay on epithelialization and cancellous bone formation was detected on the 10th post-extraction day for either simple or surgical extractions in cirrhotic animals. Conclusions: Liver cirrhosis in rats provokes a significant delay on epithelialization and mature cancellous bone formation and consecutively on early socket wound healing after a tooth extraction.

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“…Με το ίδιο σκεπτικό σχεδιάστηκε και µελετήθηκε από τους Μπαλλά και συν. 423 η επίδραση της πρώιµης χορήγησης οκτρεοτίδης στην ανάπτυξη οισοφαγικών κιρσών σε κιρρωτικούς επίµυες. Ο ρόλος του συστήµατος των ενδοθηλινών στην παθοφυσιολογία της πυλαίας υπέρτασης έχει εκτενώς συζητηθεί στα προηγούµενα κεφάλαια.…”

Section: τελικά αποτελέσµατα -σύγκριση των οµάδων ι και ιιunclassified

Η Επίδραση Των Ανταγωνιστών Των Υποδοχέων Των Ενδοθηλίνων Στην Πυλαία Υπέρταση

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Effect of early octreotide administration on the development of esophageal varices in cirrhotic rats

Cited by 7 publications

References 21 publications

Early Propranolol Administration Does Not Prevent Development of Esophageal Varices in Cirrhotic Rats

Early Propranolol Administration Does Not Prevent Development of Esophageal Varices in Cirrhotic Rats

Effect of Experimentally Induced Liver Cirrhosis on Wound Healing of the Post-Extraction Tooth Socket in Rats

Η Επίδραση Των Ανταγωνιστών Των Υποδοχέων Των Ενδοθηλίνων Στην Πυλαία Υπέρταση

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