Effect of early multisensory massage intervention on visual functions in infants with Down syndrome

Purpura, Giulia; Tinelli, Francesca; Bargagna, Stefania; Bozza, Margherita; Bastiani, Luca; Cioni, Giovanni

doi:10.1016/j.earlhumdev.2014.08.016

Cited by 39 publications

(30 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This tool allows for a rapid assessment of visual acuity (grating) in infants and young children and other populations where verbal response to recognition of visual acuity charts (letters) is difficult or impossible [26]. It evaluates development of visual acuity and has been used in several studies for diagnostic purposes and to assess results of early intervention [27, 28]. …”

Section: Methodsmentioning

confidence: 99%

A randomized clinical trial in preterm infants on the effects of a home-based early intervention with the 'CareToy System'

et al. 2017

Self Cite

View full text Add to dashboard Cite

CareToy system is an innovative tele-rehabilitative tool, useful in providing intensive, individualized, home-based, family-centred Early Intervention (EI) in infants. Our aim was to evaluate, through a Randomized Clinical Trial (RCT) study, the effects of CareToy intervention on early motor and visual development in preterm infants. 41 preterm infants (range age: 3.0–5.9 months of corrected age) were enrolled and randomized into two groups, CareToy and Standard Care. 19 infants randomized in CareToy group performed a 4-week CareToy program, while 22 allocated to control group completed 4 weeks of Standard Care. Infant Motor Profile (IMP) was primary outcome measure, Alberta Infant Motor Scale (AIMS) and Teller Acuity Cards were secondary ones. Assessments were carried out at baseline (T0) and at the end of CareToy training or Standard Care period (T1). T1 was the primary endpoint. After RCT phase, 17 infants from control group carried out a 4-week CareToy program, while 18 infants from the CareToy group continued with Standard Care. At the end of this phase, infants were re-assessed at T2. In RCT phase, delta IMP total score and variation and performance sub-domains were significantly higher (P<0.050) in CareToy group if compared to Standard Care group. Similar results were found for Teller Acuity Cards, while no differences between groups were found for AIMS. No differences were found in any outcome measure results (T2-T0), between infants who started CareToy training before or after one month of standard care. This RCT study confirms the results of a previous pilot study, indicating that CareToy system can provide effective home-based EI.Trial Registration: This trial has been registered at www.clinicaltrials.gov (Identifier NCT01990183).

show abstract

Section: Methodsmentioning

confidence: 99%

A randomized clinical trial in preterm infants on the effects of a home-based early intervention with the 'CareToy System'

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Acceleration of visual acuity development in preterm babies treated with body massage indicates the important role of multisensory stimulation from the environment on brain maturation. Similarly, Purpura et al (2014) have described positive and profound effects on visual system development (including visual acuity and stereopsis maturation) of multisensory intervention, including IM, in infants with Down Syndrome. Moreover, Guzzetta et al (2011) have demonstrated that a multisensory stimulation, such as an IM-based therapy, also facilitates the process of maturation of brain electrical activity in low-risk preterm infants, similarly to that observed ( in utero ) in term infants, in particular for the delta and beta band activity.…”

Section: Environmental Enrichment and Multisensory Stimulation In Neumentioning

confidence: 87%

Multisensory-Based Rehabilitation Approach: Translational Insights from Animal Models to Early Intervention

2017

Self Cite

View full text Add to dashboard Cite

Multisensory processes permit combinations of several inputs, coming from different sensory systems, allowing for a coherent representation of biological events and facilitating adaptation to environment. For these reasons, their application in neurological and neuropsychological rehabilitation has been enhanced in the last decades. Recent studies on animals and human models have indicated that, on one hand multisensory integration matures gradually during post-natal life and development is closely linked to environment and experience and, on the other hand, that modality-specific information seems to do not benefit by redundancy across multiple sense modalities and is more readily perceived in unimodal than in multimodal stimulation. In this review, multisensory process development is analyzed, highlighting clinical effects in animal and human models of its manipulation for rehabilitation of sensory disorders. In addition, new methods of early intervention based on multisensory-based rehabilitation approach and their applications on different infant populations at risk of neurodevelopmental disabilities are discussed.

show abstract

“…Moreover, sensorimotor enrichment was associated with improved Leiter International Performance Scale-Revised scores (a measure of objective nonverbal cognitive abilities), significant increases in IQ, Reynell receptive language scores, and improvements in sensory reactivity (Woo & Leon, 2013;Woo et al, 2015). Using similar forms of sensorimotor stimulation, there is now an emerging body of clinical work supporting the use of EE in young patients with Down syndrome, cerebral palsy, and Rett syndrome (Downs et al, 2018;Morgan, Novak, & Badawi, 2013;Morgan, Novak, Dale, & Badawi, 2015;Purpura et al, 2014). While there is some initial evidence that EE exposure changes the expression of IGF and BDNF in both humans and animals (Baldini et al, 2013;Downs et al, 2018;Field et al, 2008;Landi, Ciucci, Maffei, Berardi, & Cenni, 2009), the underlying mechanisms and necessary/sufficient components of the EE protocols that promote clinical benefit are not fully understood.…”

Section: Harnessing the Environment To Promote Resiliency To Early mentioning

confidence: 99%

“…Overall, these basic research findings underscore the importance of environmental factors in mediating parental contributions to offspring outcomes through behavioral and potentially epigenetic mechanisms (Yeshurun & Hannan, 2018; described in the next section). This is important to note given that the clinical application of EE in pediatric settings is typically administered by parents (Downs et al, 2018;Morgan et al, 2013Morgan et al, , 2015Purpura et al, 2014;Woo & Leon, 2013;Woo et al, 2015) and not surprisingly, at least for children with autism, therapy is more likely to be beneficial if parents are adherent to the intervention procedures (Aronoff et al, 2016). At this point it is unclear how the parental driven EE interventions affect the parent-child relationship, or even functioning of the caregiver (e.g.…”

Section: Harnessing the Environment To Promote Resiliency To Early mentioning

confidence: 99%

Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

Kentner

Cryan

Brummelte

2018

Developmental Psychobiology

View full text Add to dashboard Cite

Despite the increasing attention to early life adversity and its long‐term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later‐life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.

show abstract

Effect of early multisensory massage intervention on visual functions in infants with Down syndrome

Cited by 39 publications

References 25 publications

A randomized clinical trial in preterm infants on the effects of a home-based early intervention with the 'CareToy System'

A randomized clinical trial in preterm infants on the effects of a home-based early intervention with the 'CareToy System'

Multisensory-Based Rehabilitation Approach: Translational Insights from Animal Models to Early Intervention

Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

Contact Info

Product

Resources

About