Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

Kentner, Amanda C.; Cryan, John F.; Brummelte, Susanne

doi:10.1002/dev.21775

Cited by 54 publications

(46 citation statements)

References 378 publications

(517 reference statements)

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“…Participants with high BMI (high BMI group and men with high BMI) showed associations between food addiction and other, non‐general ELAs (physical and sexual), perhaps reflecting the more deleterious nature of these ELAs. Individuals with a history of general ELA (as opposed to physical or sexual) may be more likely to translate these experiences into adulthood resiliency, which may explain the potentially protective nature of these experiences . These findings provide a more nuanced understanding of the relationship between ELA and food addiction.…”

Section: Discussionmentioning

confidence: 81%

History of early life adversity is associated with increased food addiction and sex‐specific alterations in reward network connectivity in obesity

Osadchiy

Mayer

Bhatt

et al. 2019

Obesity Science & Practice

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BackgroundNeuroimaging studies have identified obesity-related differences in the brain's resting state activity. An imbalance between homeostatic and reward aspects of ingestive behaviour may contribute to obesity and food addiction. The interactions between early life adversity (ELA), the reward network and food addiction were investigated to identify obesity and sex-related differences, which may drive obesity and food addiction. MethodsFunctional resting state magnetic resonance imaging was acquired in 186 participants (high body mass index [BMI]: ≥25: 53 women and 54 men; normal BMI: 18.50-24.99: 49 women and 30 men). Participants completed questionnaires to assess ELA (Early Traumatic Inventory) and food addiction (Yale Food Addiction Scale). A tripartite network analysis based on graph theory was used to investigate the interaction between ELA, brain connectivity and food addiction. Interactions were determined by computing Spearman rank correlations, thresholded at q < 0.05 corrected for multiple comparisons. ResultsParticipants with high BMI demonstrate an association between ELA and food addiction, with reward regions playing a role in this interaction. Among women with high BMI, increased ELA was associated with increased centrality of reward and emotion regulation regions. Men with high BMI showed associations between ELA and food addiction with somatosensory regions playing a role in this interaction. ConclusionsThe findings suggest that ELA may alter brain networks, leading to increased vulnerability for food addiction and obesity later in life. These alterations are sex specific and involve brain regions influenced by dopaminergic or serotonergic signalling.

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Section: Discussionmentioning

confidence: 81%

History of early life adversity is associated with increased food addiction and sex‐specific alterations in reward network connectivity in obesity

Osadchiy

Mayer

Bhatt

et al. 2019

Obesity Science & Practice

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“…When looking at resilience induced by stress, it seems that recovery from stress-inducing changes in neural architecture is not simply a reversal, but instead is a form of neuroplastic adaptation (McEwen, Gray, et al, 2015). Although neural plasticity and epigenetic factors are known to underlie the mechanisms responsible for ELS inducing resilience in adults (Cadet, 2016; Kentner, Cryan, & Brummelte, 2018; McEwen, Gray, et al, 2015), there remains no clear understanding of the mechanisms involved in these processes and how they are functionally associated.…”

Section: Discussionmentioning

confidence: 99%

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Fontana

Gibbon

Sudwarts

et al. 2020

Preprint

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5Early-life stress (ELS) is defined as a short or chronic period of trauma, environmental or 3 6 social deprivation, which can affect different neurochemical and behavioral patterns during 3 7 adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human 3 8 neurodevelopmental disorders and display translationally relevant behavioral and stress-regulating 3 9systems. In this study, we aimed to investigate the effects of moderate ELS by exposing young 4 0 animals (six weeks post-fertilization), for three consecutive days, to three stressors, and analyzing 4 1 the impact of this on adult zebrafish behavior (sixteen weeks post-fertilization). The ELS impact in 4 2 adults was assessed though analysis of performance on tests of unconditioned memory (free 4 3 movement pattern Y-maze test), exploratory and anxiety-related task (novel tank diving test) and 4 4 social cohesion (shoaling test). Here, we show for the first time that moderate ELS increases the 4 5 number of pure alternations compared to pure repetitions in the unconditioned Y-maze task, 4 6suggesting increased spatial short-term memory, but has no effect on shoal cohesion, locomotor 4 7 profile or anxiety-like behavior. Overall, our data suggest that moderate ELS may be linked to 4 8 adaptive flexibility which contributes to build 'resilience' in adult zebrafish by improving short-4 9 term spatial memory performance. 5 0 5 1

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“…Multiple lines of evidence indicate that abnormal composition of gut microbiota may contribute to resilience versus susceptibility in rodents after either CSDS or inescapable electric stress [7,[49][50][51][52][53][54]. Further study of the role of braingut microbiota and spleen in stress susceptibility and resilience is also of interest (Fig.…”

Section: Discussionmentioning

confidence: 99%

Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine

Zhang

Sakamoto

Chang

et al. 2019

Eur Arch Psychiatry Clin Neurosci

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The spleen is a large immune organ that plays a key role in the immune system. The precise molecular mechanisms underlying the relationship between the spleen and stress-related psychiatric disorders are unknown. Here we investigated the role of spleen in stress-related psychiatric disorders. FACS analysis was applied to determine the contribution of the spleen to susceptibility and resilience in mice that were subjected to chronic social defeat stress (CSDS). We found a notable increase in splenic volume and weight in CSDS-susceptible mice compared to control (no CSDS) mice and CSDS-resilient mice. The number of granulocytes, but not of T cells and B cells, in the spleen of susceptible mice was higher than in the spleen of both control and resilient mice. Interestingly, NKG2D (natural killer group 2, member D) expression in the spleen of CSDS-susceptible mice was higher than that in control mice and CSDS-resilient mice. In addition, NKG2D expression in the spleen of patients with depression was higher than that in controls. Both increased splenic weight and increased splenic NKG2D expression in CSDS-susceptible mice were ameliorated after a subsequent administration of (R)-ketamine. The present findings indicate a novel role of splenic NKG2D in stress susceptibility versus resilience in mice subjected to CSDS. Furthermore, abnormalities in splenic functions in CSDS-susceptible mice were ameliorated after subsequent injection of (R)-ketamine. Thus, the brain-spleen axis might, at least in part, contribute to the pathogenesis of stress-related psychiatric disorders such as depression.

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Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

Cited by 54 publications

References 378 publications

History of early life adversity is associated with increased food addiction and sex‐specific alterations in reward network connectivity in obesity

History of early life adversity is associated with increased food addiction and sex‐specific alterations in reward network connectivity in obesity

Moderate early-life stress improves adult zebrafish (Danio rerio) spatial short-term memory but does not affect social and anxiety-like responses

Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine

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