Effect of Drugs with Various Mechanisms of Action on Propulsive Activity of the Small Intestine

Abstract

We studied the effect of drugs with various mechanisms of action on propulsive activity of the small intestine in healthy rats. Blockade of the major inhibitory influences realized via nonadrenergic noncholinergic inhibitory effector neurons was not followed by stimulation of intestinal transit. Propulsive activity of the small intestine increased upon treatment with drugs, whose effects are realized via acetylcholine or acetylcholine and serotonin.

Role of Serotoninergic System in the Development of Gastrointestinal Diseases

“…Through these receptors serotonin (5-HT) regulates the contractile activity of smooth muscles [1,4,13,14]. Serotonin induces contractions of the smooth-muscle cells of the fundal compartment of the stomach during reaction with 5-HT 2B receptors [4,6,8,12]. The contractile effect of 5-HT towards the smooth muscles of the gastric fundal compartment is confirmed by other studies [6,8,12].…”

“…Intramural ganglionar neurons and enterochromaffine cells have surface 5-HT 3 and 5-HT 4 receptors. Through these receptors serotonin (5-HT) regulates the contractile activity of smooth muscles [1,4,13,14]. Serotonin induces contractions of the smooth-muscle cells of the fundal compartment of the stomach during reaction with 5-HT 2B receptors [4,6,8,12].…”

Serotoninergic system in the development of pyloric stenosis and pancreatitis

“…Experimental data on the possible role of serotoninergic systems in the development of pyloric stenosis was confirmed by other authors [5]. The development of pyloric stenosis in stubborn gastroduodenal ulcers is associated with intensive release of serotonin stimulating the serotonin receptors of the effector tissues in the pyloric channel and antral portion of the stomach.…”

“…However, activation of 5-HT 2 receptors by endogenous serotonin is not the only effect of this substance on the secretory motor activity of the pancreas and its duct. The role of serotonin-activated 5-HT 1 and 5-HT 3,4 receptors is not quite clear, and hence, the impact of serotonin in general for pancreatitis development cannot be completely characterized.Propulsive activity of the gastrointestinal tract depends on the stimulatory effect of serotonin on smooth muscles [1] and on the stimulatory influences realized via acetylcholine [5]. Impairment of the sphincter function, for example, in duodenal ulcer, leads to dissociation of the gastroduodenal motility.…”

“…Propulsive activity of the gastrointestinal tract depends on the stimulatory effect of serotonin on smooth muscles [1] and on the stimulatory influences realized via acetylcholine [5]. Impairment of the sphincter function, for example, in duodenal ulcer, leads to dissociation of the gastroduodenal motility.…”