Effect of drug-related cues on response inhibition through abstinence: A pilot study in male heroin abstainers

Su, Bobo; Yang, Ling; Wang, Grace; Wang, Sha; Li, Shaomei; Cao, Hua; Zhang, Yan

doi:10.1080/00952990.2017.1283695

Cited by 16 publications

(8 citation statements)

References 31 publications

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“…For this, the research adopts the Two-Choice Oddball paradigm. In previous studies, this paradigm has been successfully used to examine BIC associated with substance use disorders (e.g., Su et al, 2017;Zhao, Liu, & Maes, 2017).…”

Section: Impulsivitymentioning

confidence: 99%

Event-related potentials in a two-choice oddball task of impaired behavioral inhibitory control among males with tendencies towards cybersex addiction

Wang

Dai

2020

JBA

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Background and aimsImpaired behavioral inhibitory control (BIC) is known to play a crucial role in addictive behavior. However, research has been inconclusive as to whether this is also the case for cybersex addiction. This study aimed to investigate the time course of BIC in male individuals with tendencies towards cybersex addiction (TCA) using event-related potentials (ERPs) and to provide neurophysiological evidence of their deficient BIC.MethodsThirty-six individuals with TCA and 36 healthy controls (HCs) were given a Two-Choice Oddball task that required them to respond differently to frequent standard stimuli (images of people) and infrequent deviant stimuli (pornographic images) within 1,000 ms. Electroencephalography (EEG) was recorded as the participants performed the task.ResultsDespite the similarity of standard stimuli between the groups in terms of reaction times (RTs), the RTs of the TCA group to deviant stimuli were much slower than those of the HC group. The behavioral difference was accompanied by group differences in the averaged amplitudes of N2 (200–300 ms) and P3 (300–500 ms) components in the deviant-standard difference wave. More specifically, compared to the HC group, the TCA group demonstrated smaller N2 and P3 amplitude differences for deviant than standard stimuli.Discussion and conclusionsIndividuals with TCA were more impulsive than HC participants and shared neuropsychological and ERP characteristics of substance use disorder or behavioral addictions, which supports the view that cybersex addiction can be conceptualized as a behavioral addiction.

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Section: Impulsivitymentioning

confidence: 99%

Event-related potentials in a two-choice oddball task of impaired behavioral inhibitory control among males with tendencies towards cybersex addiction

Wang

Dai

2020

JBA

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“…Moreover, chronic opioid use and opioid dependence are associated with diminished cognitive control functions, including deficits in response inhibition [16][17][18][19], which can persist beyond cessation of and withdrawal from opioid use [20,21]. Opioid-dependent individuals exhibit attenuated inhibitory control-related fMRI BOLD signal in medial prefrontal circuitry, including the anterior cingulate cortex [22,23] and medial prefrontal cortex [24], and have worse behavioral performance compared with nonopioid-dependent persons across a broad range of task probes of response inhibition including the arrow task [25], the standard Go/NoGo task [22], and the affective Go/NoGo task [26].…”

Section: Opioid Use and Response Inhibitionmentioning

confidence: 99%

Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study

Garland

Bryan

Priddy

et al. 2019

Annals of Behavioral Medicine

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Background Among opioid-treated chronic pain patients, deficient response inhibition in the context of emotional distress may contribute to maladaptive pain coping and prescription opioid misuse. Interventions that aim to bolster cognitive control and reduce emotional reactivity (e.g., mindfulness) may remediate response inhibition deficits, with consequent clinical benefits. Purpose To test the hypothesis that a mindfulness-based intervention, Mindfulness-Oriented Recovery Enhancement (MORE), can reduce the impact of clinically relevant, negative affective interference on response inhibition function in an opioid-treated chronic pain sample. Methods We examined data from a controlled trial comparing adults with chronic pain and long-term prescription opioid use randomized to either MORE (n = 27) treatment or to an active support group comparison condition (n = 30). Participants completed an Emotional Go/NoGo Task at pre- and post-treatment, which measured response inhibition in neutral and clinically relevant, negative affective contexts (i.e., exposure to pain-related visual stimuli). Results Repeated-measures analysis of variance indicated that compared with the support group, participants in MORE evidenced significantly greater reductions from pre- to post-treatment in errors of commission on trials with pain-related distractors relative to trials with neutral distractors, group × time × condition F(1,55) = 4.14, p = .047, η2partial = .07. Mindfulness practice minutes and increased nonreactivity significantly predicted greater emotional response inhibition. A significant inverse association was observed between improvements in emotional response inhibition and treatment-related reductions in pain severity by 3-month follow-up. Conclusions Study results provide preliminary evidence that MORE enhances inhibitory control function in the context of negative emotional interference.

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“…It is possible that deficits of inhibitions may be reduced with increased length of abstinence. In our recent study, we found that RT for drug-related deviants were shorted in longer-term heroin abstainers (16-24 months) compared to those having shorter period of abstinence (2-6 months) (Su et al, 2017). Longitudinal research should be implemented to clarify the cognition change induced by length of abstinence.…”

Section: Discussionmentioning

confidence: 99%

“…Pictures used in our two-choice oddball paradigm were the same as those used in our previous studies (Su et al, 2017;Yang et al, 2015a) which included 20 neutral pictures (e.g. household objects, tools, neutral facial expressions) selected from International Affective Pictures System (IAPS) (Lang et al, 2005), and 20 heroin-related pictures consisting of the scenario of preparing or using heroin, drug or drug tool collected from freely available online sources.…”

Section: Stimuli and Proceduresmentioning

confidence: 99%

“…Consequently, reaction time (RT) tends to be prolonged for the deviant stimuli compared to the standard stimuli. It is designed to assess the general response inhibition and provides response inhibition specific ERPs free of motor contamination with an additional RT index of response inhibition (Su et al, 2017;Wang et al, 2011;Yuan et al, 2008;Yuan et al, 2012). To avoid possible interference between trials associated with a random design (Wang et al, 2011), we used block-design to present the neutral and drug-related pictures as deviant stimuli of different blocks respectively.…”

Section: Introductionmentioning

confidence: 99%

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Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers

Wang

Sumich

et al. 2017

Psychopharmacology

Self Cite

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Rationale Chronic heroin use can cause deficits in response inhibition, leading to a loss of control over drug use, particularly in the context of drug-related cues. Unfortunately, heightened incentive salience and motivational bias in response to drug-related cues may exist following abstinence from heroin use.Objectives The present study aimed to examine the effect of drug-related cues on response inhibition in long-term heroin abstainers.Methods Sixteen long-term (8-24 months) male heroin abstainers and 16 male healthy controls completed a modified two-choice oddball paradigm, in which a neutral "chair" picture served as frequent standard stimuli, the neutral and drug-related pictures served as infrequent deviant stimuli of different conditions respectively. Event-related potentials were compared across groups and conditions.Results Our results showed that heroin abstainers exhibited smaller N2d amplitude (deviant minus standard) in the drug cue condition compared to the neutral condition, due to smaller drug-cue deviant-N2 amplitude compared to neutral deviant-N2. Moreover, heroin abstainers had smaller N2d amplitude compared with the healthy controls in the drug cue condition, due to the heroin abstainers having reduced deviant-N2 amplitude compared to standard-N2 in the drug cue condition, which reversed in the healthy controls.Conclusions Our findings suggested that heroin addicts still show response inhibition deficits specifically for drug-related cues after longer-term abstinence. The inhibition-related N2 modulation for drug-related could be used as a novel electrophysiological index with clinical implications for assessing the risk of relapse and treatment outcome for heroin users.

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Effect of drug-related cues on response inhibition through abstinence: A pilot study in male heroin abstainers

Cited by 16 publications

References 31 publications

Event-related potentials in a two-choice oddball task of impaired behavioral inhibitory control among males with tendencies towards cybersex addiction

Event-related potentials in a two-choice oddball task of impaired behavioral inhibitory control among males with tendencies towards cybersex addiction

Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study

Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers

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