Effect of doxazosin therapy on glucose tolerance and lipid metabolism in hypertensive patients with impaired glucose tolerance

Effect of Doxazosin on Insulin Resistance in Hypertensive Patients with Obesity

“…Doxazosin has been shown to have a favorable effect on insulin resistance [11,12,14]. In addition, doxazosin treatment improved lipid profiles in patients with hypertension by lowering TC [12,14,16 ± 18], triglycerides [13,14,17,19], LDL and oxidized LDL [12,13,18,20], very-low-density lipoproteins [13,14], and by increasing HDL [16] and LDL particle size [21].…”

Managing Hypertension in Patients with Diabetes

“…No data is available for tamsulosin. Doxazosin improved glucose and lipid metabolism in diabetic patients and in patients with impaired glucose tolerance [128,129]. It has also been reported to improve insulin resistance, and increase LDL particle size [130,131].…”

Glycated Haemoglobin: A Predictor of Vascular Risk?

“…It follows that drugs that improve insulin sensitivity may provide an additional benefit. [23][24][25][26][27][28][29][30][31][32][33] Fibrates are useful in mixed dyslipidaemias and they may also exert a small beneficial effect on insulin sensitivity. 23,24,25 One fibrate, gemfibrozil, significantly reduced (22 %; p = 0.006) the risk of vascular events in a secondary prevention trial that included diabetic individuals (at least 25% of the trial population) and patients with the features of the insulin resistance syndrome.…”

“…doxazosin) that increase insulin sensitivity may also be useful in these patient populations. 27,28 There is also evidence showing that hormone replacement therapy (HRT) improves long-term glucose homeostasis (as indicated by HbA 1c measurements). 30 However, this finding requires confirmation.…”