Effect of dosing schemes of amoxicillin on eradication rates of Helicobacter pylori with amoxicillin‐based triple therapy

Abstract

The dosing scheme of amoxicillin significantly influenced eradication rates of triple therapies. Although amoxicillin is empirically dosed twice daily, amoxicillin should be dosed at least three times daily in amoxicillin-based triple therapies.

Effect of IL-1 Polymorphisms, CYP2C19 Genotype and Antibiotic Resistance on Helicobacter pylori Eradication Comparing Between 10-day Sequential Therapy and 14-day Standard Triple Therapy with Four-Times-Daily-Dosing of Amoxicillin in Thailand: a Prospective Randomized Study

“…Recent studies from Japan have demonstrated that the eradication rates in clarithromycin-based triple regimens with qid dosing of amoxicillin were higher than those of regimens with the bid dosing of amoxicillin about 14% (91.9% and 77.8% respectively.) (Furuta et al, 2014). The data on the effectiveness of the dosing scheme of amoxicillin triple therapy with clarithromycin-containing regimen in Thailand are limited.…”

“…Interestingly, recent study has demonstrated the positive effect of the dosing scheme of amoxicillin significantly influenced eradication rates of triple therapies. Eradication rates in regimens with tid and qid dosing of amoxicillin were higher than those of regimens with the bid dosing of amoxicillin (Furuta et al, 2014). One of the popular present first-line treatment options is sequential regimen, which has shown higher eradication rates than conventional triple therapy in several recent meta-analyses (Zullo et al, 2007;Jafri et al, 2008;Gatta et al, 2009).…”

Gastric Mucosal Atrophy Might Be Associated with the Efficacy of First-Line Therapy Using Vonoprazan for <i>Helicobacter pylori</i>

“…The antimicrobial action of AMPC depends on the ratio between dosing interval and time over MIC (% Time-above MIC). For an AMPC insensitive strain, the shortening of % Time-above MIC due to an increase in the MIC is the cause of failure to eradicate H. pylori [44].…”

Letter: sitafloxacin for H. pylori infection in Japan: considerations on resistance rates, generalisability and its place in the therapeutic algorithm – author's reply

“…Although a recent study has also reported a seasonal variation in EoE-related food impaction, 7 food impaction is usually a consequence of the fibrotic oesophageal remodelling in patients with long-standing EoE. 6 Likewise, food impaction during outdoor seasons might also be related to different food and social behaviours during holidays. EoE patients are usually sensitised to indoor perennial aeroallergens 8 and de novo onset of EoE has been associated with exposure to mould and dust.…”

“…An EoE diagnosis is established in symptomatic patients after upper endoscopy with oesophageal biopsies. Diagnostic delay since the onset of symptoms is extremely common, 6 due to variables related to patients (underestimation of symptoms, avoidance of medical attention or eating behaviour modifications), physicians (lack of suspicion, lack of biopsies during endoscopy) and hospitals (waiting time for endoscopy). As such, equating the onset of clinical manifestations, potentially triggered by seasonal aeroallergens, with the time of performance of the endoscopy may be inaccurate.…”