2016
DOI: 10.7314/apjcp.2016.17.4.1903
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Effect of IL-1 Polymorphisms, CYP2C19 Genotype and Antibiotic Resistance on Helicobacter pylori Eradication Comparing Between 10-day Sequential Therapy and 14-day Standard Triple Therapy with Four-Times-Daily-Dosing of Amoxicillin in Thailand: a Prospective Randomized Study

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Cited by 19 publications
(27 citation statements)
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“…Curing H. pylori infection still remains a challenge in clinical practice. The 10-day sequential therapy, suggested as first-line therapy in the current Italian guidelines [3], has been proven to be effective in several countries, achieving eradication rates as high as 91.1%-93.7% in Italy [7,11], 92.5-95% in Turkey [12,13], 94.2% in Slovenia [14], 90% in Portugal [15], 90% in Belgium [16], 95.9% in Israel [17], 94% in Thailand [18], 91.9% in Taiwan [19], 90.3% in Singapore [20], and 88.6% in the United Arab Emirates [21]. In detail, the 10-day sequential therapy was found to be equally effective -but cheaper -than J Gastrointestin Liver Dis, March 2019 Vol.…”
Section: Discussionmentioning
confidence: 99%
“…Curing H. pylori infection still remains a challenge in clinical practice. The 10-day sequential therapy, suggested as first-line therapy in the current Italian guidelines [3], has been proven to be effective in several countries, achieving eradication rates as high as 91.1%-93.7% in Italy [7,11], 92.5-95% in Turkey [12,13], 94.2% in Slovenia [14], 90% in Portugal [15], 90% in Belgium [16], 95.9% in Israel [17], 94% in Thailand [18], 91.9% in Taiwan [19], 90.3% in Singapore [20], and 88.6% in the United Arab Emirates [21]. In detail, the 10-day sequential therapy was found to be equally effective -but cheaper -than J Gastrointestin Liver Dis, March 2019 Vol.…”
Section: Discussionmentioning
confidence: 99%
“…Patients diagnosed with non-ulcer dyspepsia as established during gastroscopy with normal findings or mild gastritis were included in the study. On the other hand, patients with a history of gastric surgery or those who were taking medications in the preceding four weeks (such as anticoagulants, antibiotics, and proton pump inhibitors) were excluded from the study [22,23]. Participants' demographics such as age, gender, height, and weight were collected using a structured questionnaire, and their clinical history was obtained from their medical files and records.…”
Section: Methodsmentioning
confidence: 99%
“…The outcome of CYP2C19 genotype testing were demonstrated as: rapid metabolizer (RM), intermediate metabolizer (IM) or poor metabolizer (PM). CYP2C19 genotypes have effect on pharmacokinetics and pharmacodynamics of PPI which involved in changing gastric pH and effectiveness of H. pylori eradication (Phiphatpatthamaamphan et al, 2016) Currently, H. pylori resistance rates to antibiotics are becoming problem in most parts of the world. H. pylori antibiotic resistance caused eradication rates have been declining while the prevalence of antibiotic resistance rates have been increasing (Malfertheiner et al, 2017) In Thailand, Antibiotic resistance was presented in 50.3% including amoxicillin 5.2%, tetracycline 1.7%, clarithromycin 3.7%, metronidazole 36%, ciprofloxacin 7.7%, Levofloxacin 7.2% and multi-drugs in 4.2% (Vilaichone et al, 2013).…”
Section: Introductionmentioning
confidence: 99%