Effect of dose and day of treatment on uterine response to oxytocin in mares

Gutjahr, S.; Paccamonti, D.; Pycock, Jonathan F.; Taverne, M.A.M.; Dieleman, S.J.; Weijden, G.C. van der

doi:10.1016/s0093-691x(00)00361-7

Cited by 34 publications

(26 citation statements)

References 16 publications

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“…Other factors in multiparous mares include altered neuromuscular interactions [34], or impaired lymphatic drainage [11] due to partial dilation of the uterus [39] or caudo-ventral displacement of the uterus [21]. All of these conditions enhance intrauterine inflammation and fluid accumulation [39,14]. …”

Section: Pathophysiology Of Ppbemmentioning

confidence: 99%

“…One to two litres of warm, sterile saline or a 0.05% povidone-iodine solution (5 ml of a 10% povidone-iodine solution to each litre of balanced salt solution) [6] are infused via a large-bore equine embryo-flushing catheter until the recovered fluid is clear. This should be followed by administration of uterotonic substances such as oxytocin [31]; 10 IU preovulatory and 25 IU post-ovulatory, IV or IM [14]. …”

Section: Treatment Optionsmentioning

confidence: 99%

“…The day upon which oxytocin is administered also plays an important role in the contractility of the endometrium [14]. It is suggested that mares that are susceptible to post-breeding endometritis should have more time between breeding (24-48 hours before ovulation) and ovulation [14,29].…”

Section: Treatment Optionsmentioning

confidence: 99%

“…Persistent post-breeding endometritis (PPBEM) is the third most common medical condition of adult female horses [37] and the major reason for failure to conceive [14]. It affects approximately 15% of Thoroughbred mares after natural cover [47].…”

Section: Introductionmentioning

confidence: 99%

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Equine post-breeding endometritis: A review

et al. 2008

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The deposition of semen, bacteria and debris in the uterus of the mare after breeding normally induces a self-limiting endometritis. The resultant fluid and inflammatory products are cleared by 48 hours post cover. Mares that are susceptible to persistent post-breeding endometritis (PPBEM) have impaired uterine defence and clearance mechanisms, making them unable to resolve this inflammation within the normal time. This persists beyond 48 hours post-breeding and causes persistent fluid accumulation within the uterus. Mares with PPBEM have an increased rate of embryonic loss and a lower overall pregnancy rate than those without the condition. To enhance conception rates, mares at high risk need optimal breeding management as well as early diagnosis, followed by the most appropriate treatment. This article reviews the pathogenesis, diagnosis and treatment of PPBEM and the management of affected mares.

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Section: Pathophysiology Of Ppbemmentioning

confidence: 99%

Section: Treatment Optionsmentioning

confidence: 99%

Section: Treatment Optionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Equine post-breeding endometritis: A review

et al. 2008

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“…Parameters that can be measured and recorded include systolic and diastolic blood pressure, mean arterial pressure, heart rate, and activity level, and is accurate to within 3 mm Hg [8]. This approach has previously been validated in the telemetric recordings of murine circadian rhythms; abnormal heart rate and body temperature; blood pressure (systolic, diastolic, and mean arterial), pain as assessed by heart rate and heart rate variability, as well as mouse penile, ocular, uterine, bladder, pleural, and left ventricular pressures [9][10][11][12][13][14][15][16][17]. The devices can be sterilized between uses, thus extending their implant life as well as reducing cost.…”

Section: Introductionmentioning

confidence: 99%