Effect of Donor Lymphocyte Infusion From Two Types of Donors on Mixed Chimerism With Secondary Graft Failure After Allogeneic Hematopoietic Stem Cell Transplantation

Ren, Ruirui; Ma, Liangming; Xie, Yunxia; Tian, Wen; Wang, Tao

doi:10.1016/j.jtct.2021.12.017

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Unselected DLI has been utilised in 16 patients with "secondary graft failure," defined as loss of donor engraftment after initial neutrophil recovery, 63% of whom had mixed chimerism with corresponding cytopenias. Fourteen of the 16 achieved a CR which was accompanied with an increase in T-reg cells, suggesting an immune tolerogenic mechanism to the response [71]. TPO agonism is another therapeutic option but requires prospective studies.…”

Section: Mixed Chimerism With Cytopenias (Mcc)mentioning

confidence: 97%

Non-relapse cytopenias following allogeneic stem cell transplantation, a case based review

Prabahran

Koldej

Chee

et al. 2022

Bone Marrow Transplant

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The development of non-relapse cytopenias (NRC) is a relatively common occurrence post allogeneic stem cell transplant (alloSCT). Whilst there have been attempts to classify post alloSCT cytopenias by transplantation groups, ambiguity of definitions in prior publications compounded by a lack of availability of high-quality evidence, provide challenges to clinicians attempting to manage these complex patients. In this review we describe 3 cases of NRC, (1) Graft Failure with graft rejection representing cytopenias with minimal donor chimerism (2) Poor Graft Function representing cytopenias with complete donor chimerism and (3) Cytopenias with mixed donor chimerism. This case-based review will evaluate the currently available evidence regarding the pathophysiology of each entity as well as the evidence for current therapies with the aim of providing guidance to clinicians managing these complex patients.

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Section: Mixed Chimerism With Cytopenias (Mcc)mentioning

confidence: 97%

Non-relapse cytopenias following allogeneic stem cell transplantation, a case based review

Prabahran

Koldej

Chee

et al. 2022

Bone Marrow Transplant

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Graft failure in allogeneic hematopoietic stem cell recipients: diagnosis and treatment

Maslikova¹,

Popova²,

Drokov³

et al. 2023

vmirvz

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Graft failure is a group of complications after allogeneic hematopoietic stem cell transplantation, which occurs according to different data up to 30%. The group of complications includes primary and secondary graft failure, primary, secondary and transient poor graft function and graft rejection. Diagnostic difficulties consist in the lack of unified diagnostic criteria accepted in the transplantation community and in the dual interpretation of these complications according to the foreign literature. The purpose of this literature review was to identify the most common criteria of different types of graft failure and determine the tactics of diagnosis and treatment. In this review we analyzed data from various literature sources, gave definitions of graft failure and poor graft function. We analyzed the literature data on the methods used to treat these conditions.

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Effect of Donor Lymphocyte Infusion From Two Types of Donors on Mixed Chimerism With Secondary Graft Failure After Allogeneic Hematopoietic Stem Cell Transplantation

Cited by 2 publications

References 30 publications

Non-relapse cytopenias following allogeneic stem cell transplantation, a case based review

Non-relapse cytopenias following allogeneic stem cell transplantation, a case based review

Graft failure in allogeneic hematopoietic stem cell recipients: diagnosis and treatment

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