Effect of Donor Kidney Volume on Recipient Outcome

Sikora, Magdalena B.; Shaaban, Akram M.; Beddhu, Srinivasan; Bourija, Hassan; Wei, Guo; Baird, Bradley C.; Truax, Crystal; Shihab, Fuad S.

doi:10.1097/tp.0b013e31826f135e

Cited by 22 publications

(20 citation statements)

References 35 publications

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“…However, after kidney volume was corrected for body surface area there was no sex difference, analogous to what it is known about GFR where there is no or minimal difference in corrected GFR between sexes. Similar findings were later reported by another single-center study [37].…”

Section: Donor Kidney Size and Its Implications To Donor And Recipiensupporting

confidence: 81%

“…This also holds true in living donation, where it has been noted that the donor kidney-recipient body size mismatch ("nephron under dosing") can lead to poor allograft function [44]. Transplantation of donor-recipient pairs with a transplant kidney volume-recipient body weight ratio less than 2 cm 3 /kg was associated with significantly worse graft function [37]. Poggio et al [31] showed that a transplanted kidney volume greater than 120 cc/1.73 m 2 was independently associated with better estimated GFR at 2 years post-transplant when compared with recipients of lower transplanted kidney volumes (64+/−19 mL/min/1.73 m 2 vs 48+/−14 mL/min/ 1.73 m 2 , p<0.001).…”

Section: Donor Kidney Size and Its Implications To Donor And Recipienmentioning

confidence: 94%

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Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

2015

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Kidney transplantation is the best treatment for patients with end-stage renal disease and recipients of living kidney donors fare better than recipients of deceased donors. In view of the shortage of organ supply and the long waiting list, expansion of the living donor pool has been sought. Importantly, donor acceptance criteria must first and foremost be grounded in concerns for donor safety. Recent studies suggesting that live kidney donors may have higher rates of end-stage renal disease in the long term compared with otherwise similar healthy persons highlights the critical importance of pre-donation evaluation of renal function and structure, and careful application in donor selection criteria. The quality of organs from living donors may also affect recipient outcomes. Because donor kidney function, histology, and anatomy pertain to the quality of the donated organ, living donor characterization of the factors associated with these features is important to the donor as well as the recipient.

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Section: Donor Kidney Size and Its Implications To Donor And Recipiensupporting

confidence: 81%

Section: Donor Kidney Size and Its Implications To Donor And Recipienmentioning

confidence: 94%

Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

2015

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“…We confirmed in our cohort as well as in an external validation cohort that the variable rk-GFR/vol was inversely associated with 5-year functional gain after controlling for age. It has already been reported that larger kidney volume estimated by CT scan was associated with better graft function (13)(14)(15). It has also been shown that the initial preserved kidney volume adjusted for body surface area is correlated with donor renal function at 6 months (31) and 1 year postdonation (17).…”

Section: Discussionmentioning

confidence: 93%

“…Consequently, the combination of predonation GFR measurement and nuclear SRF enables us to calculate the initial GFR of the remaining kidney (rk-GFR). Furthermore, it has been suggested that measurements of the volumes of the kidney to be donated and the remaining kidney using renal computed tomography scan (CT scan) are predictive of subsequent renal functions in the recipient (13)(14)(15) and the donor (16,17), respectively.…”

Section: Introductionmentioning

confidence: 99%

Association of mGFR of the Remaining Kidney Divided by Its Volume before Donation with Functional Gain in mGFR among Living Kidney Donors

Courbebaisse¹,

Tissier²,

Fournier³

et al. 2016

CJASN

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Background and objectives The predictors of long-term renal function in living kidney donors are currently discussed. Our objectives were to describe the predictors of functional gain of the remaining kidney after kidney donation. We hypothesized that GFR of the remaining kidney divided by volume of this kidney (rk-GFR/vol) would reflect the density of functional nephrons and be inversely associated with functional gain of the remaining kidney.Design, setting, participants, & measurements We conducted a prospective monocentric study including 63 living donors (26 men; 50.3611.8 years old) who had been evaluated for 51 Cr-EDTA and measured GFR, split renal function by scintigraphy before donation (between 2004 and 2009), and measured GFR at 5.760.5 years after donation. For 52 donors, volume of the remaining kidney (measured and estimated with the ellipsoid formula using renal computed tomography scannography) was determined before donation. We tested our hypothesis in an external validation cohort of 39 living donors (13 men; 51.069.4 years old) from another single center during the same time period.Results For the main cohort, the mean measured GFR was 97. Conclusions For given age and body mass index, the long-term functional gain of the remaining kidney is inversely associated with the new variable rk-GFR/vol at donation.

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“…Renal length and volumes also correlate with recipient renal function up to 36 months after transplantation. A low ratio of cortical volume to recipient weight has been associated with diminished graft function at 36 months (45)(46)(47). Hence, volumetric measurements are now becoming an important tool in selecting laterality, along with nephron dose matching with the recipient (Figure 7).…”

Section: Computed Tomographymentioning

confidence: 99%

Renal Relevant Radiology

Sharfuddin

2014

Clinical Journal of the American Society of Nephrology

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SummaryKidney transplantation can be associated with various complications that vary from vascular complications to urologic disorders to immunologic adverse effects. In evaluating the recipient with graft dysfunction, clinicians can choose among several imaging modalities, including ultrasonography, nuclear medicine studies, computed tomography, and magnetic resonance imaging. This review discusses the evaluation of the kidney transplant recipient using these imaging procedures, emphasizing the clinical diagnostic utility and role of each modality. A kidney biopsy is often required as a gold standard for diagnostic purposes. However, because of the inherent risks of a kidney biopsy, noninvasive imaging in diagnosing causes of graft dysfunction is a highly desired tool used and needed by the transplant community. Because the diagnostic accuracy varies depending on the time course and nature of the transplant-related complication, this review also addresses the advantages and limitations of each modality. The recent advances in kidney transplant imaging techniques and their clinical implications are also discussed.

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Effect of Donor Kidney Volume on Recipient Outcome

Abstract: Donor kidney volume dosing is an important determinant of recipient graft outcomes and may predict recipient kidney function in kidney transplantation.

Cited by 22 publications

References 35 publications

Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

Evaluation of Kidney Function and Structure in Potential Living Kidney Donors: Implications for the Donor and Recipient

Association of mGFR of the Remaining Kidney Divided by Its Volume before Donation with Functional Gain in mGFR among Living Kidney Donors

Renal Relevant Radiology

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