Effect of Diversion of Bile-Pancreatic Juice to the Ileum on Pancreatic Secretion and Adaptation in the Rat

Levan, Van H.; Green, Gary M.

doi:10.3181/00379727-181-42235

Cited by 13 publications

(5 citation statements)

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“…Diversion of bile/pancreatic juice enhances basal pancreatic secretion (61)(62)(63)(64)(65)(66). The effect was continuously (66,67) or transiently (68,69) inhibited by intraduodenal infusion of Na-taurocholate, cholate, chenodeoxycholate, taurochenodeoxycholate, or bile (66).…”

Section: Effect Of Bile and Bile Salts On Pancreatic Secretion Stimulmentioning

confidence: 99%

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl¹,

Lehnert²

1992

Scandinavian Journal of Gastroenterology

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Section: Effect Of Bile and Bile Salts On Pancreatic Secretion Stimulmentioning

confidence: 99%

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl¹,

Lehnert²

1992

Scandinavian Journal of Gastroenterology

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“…The pancreatic hypergrowth by diversion of BPJ was reported by Levan and Green (22) and hypersecretion of proteases.…”

Section: Discussionmentioning

confidence: 82%

Responses of the Exocrine Pancreatic Secretion to Spontaneous Feeding in Rats with Bile-Pancreatic Juice Diversion

Hara

Kiriyama

1991

Experimental Biology and Medicine

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The regulatory response of the exocrine pancreas was examined in rats under unanesthetized and unrestrained conditions. The previous study demonstrated that the pancreatic protease secretion increased 2-fold after spontaneous feeding of a low protein diet in chronically bile-pancreatic cannulated rats (normal rats) whose bile-pancreatic juice (BPJ) was returned to the duodenum. In the present study, we observed the response of the exocrine pancreatic secretion to spontaneous feeding of a low protein diet in rats with chronic diversion of BPJ from the proximal small intestine for 6 days (bypass rat) whose diverted BPJ was returned to the upper ileum. During BPJ diversion, the dry weight and the protein content of the pancreas were increased 2-fold, compared with normal rats. Also, the levels of trypsinogen and chymotrypsinogen in the pancreas were increased several times, but amylase was decreased. The basal secretion of enzymes after a 24-hr fast was enhanced in bypass rats in proportion to the pancreatic enzyme contents. After spontaneous feeding of 8% casein fat-free diet, the increases in the pancreatic secretion of bypass rats were much smaller than those of normal rats. In contrast, the increase of BPJ flow of bypass rats after feeding was greater than that of normal rats. These findings represent that the chronic diversion of BPJ exerts hypergrowth of pancreas and hypersecretion of proteases in the fasting state, and less sensitivity of pancreatic enzyme secretion to dietary feeding.

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“…28 ) Chronic BPJ diversion from the proximal small intestine induced pancreatic hypertrophy and hyperplasia (increases in protein, DNA, and RNA) as shown in the present study, these results having been previously reported. 8,29) The total activities of trypsin and chymotrypsin in the pancreas were makredly increased, their specific activities being 2-fold higher in the PBD group than those in the normal and intact groups (Figs. 1 and 2).…”

Section: Discussionmentioning

confidence: 98%