Changes in Messenger RNA of Pancreatic Enzymes and Intestinal Cholecystokinin after a 7-Day Bile-pancreatic Juice Diversion from the Proximal Small Intestine in Rats

Hara, Hiroshi; Ochi, Yasuo; Kasai, Takanori

doi:10.1271/bbb.61.1002

Bioscience, Biotechnology, and Biochemistry

1997

DOI: 10.1271/bbb.61.1002

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Changes in Messenger RNA of Pancreatic Enzymes and Intestinal Cholecystokinin after a 7-Day Bile-pancreatic Juice Diversion from the Proximal Small Intestine in Rats

Hiroshi Hara¹,

Yasuo Ochi²,

Takanori Kasai³

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2003

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“…In this rat, inductions of pancreatic enzyme secretion and enzyme content are mainly mediated by a gut hormone, cholecystokinine (CCK) (Lee, 1986;Miazza, 1987;Hara, 1997). This has been proved by several studies that demonstrated elevated pancreatic enzyme secretion and growth in BPJ-diverted rats were blocked by CCK receptor antagonists (Gasslander, 1990;Nakamura, 1989;Nylander, 1992;Rivard, 1991;Taguchi, 1992;Watanapa, 1991).…”

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l -Homoarginine suppresses exocrine pancreas in rats

2003

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SUMMARYPreviously, we found that guanidinated casein, a L-homoarginine-containing protein, was a more potent stimulator of pancreatic enzyme secretion than intact casein in rats. In this study, we examined secretory response and adaptation of the exocrine pancreas to the administration of free L-homoarginine in normal and bile-pancreatic juice (BPJ)-diverted rats.An intraperitoneal injection of L-homoarginine (10 mg/rats) produced immediate and transient reduction in pancreatic secretion in BPJ-diverted rats, but not in normal rats. The BPJ-diverted rats were fed with either a 25% casein, 45% casein, or 45% casein diet supplemented with L-homoarginine (19 g/kg diet) for 4 days. Feeding of a diet containing L-homoarginine inhibited the pancreatic adaptation induced by the high-protein diet. These results indicate that L-homoarginine has an inhibitory effect on the secretion and production of exocrine pancreatic enzyme in BPJ-diverted rats, and L-homoarginine may have an antagonistic effect on CCK receptors.

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l -Homoarginine suppresses exocrine pancreas in rats

2003

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Changes in Messenger RNA of Pancreatic Enzymes and Intestinal Cholecystokinin after a 7-Day Bile-pancreatic Juice Diversion from the Proximal Small Intestine in Rats

Cited by 1 publication

References 13 publications

l -Homoarginine suppresses exocrine pancreas in rats

l -Homoarginine suppresses exocrine pancreas in rats

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