Effect of diquafosol three per cent ophthalmic solution on tear film and corneal aberrations after cataract surgery

Lee, Hun; Kim, Sang Myung; Choi, Sanghyun; Seo, Kyoung Yul; Kim, Eung Kweon; Kim, Tae Im

doi:10.1111/cxo.12521

Cited by 14 publications

(19 citation statements)

References 27 publications

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“…With the emergence of new aqueous tears and/or mucin secretagogue eye drops containing diquafosol sodium (Diquas) or rebamipide (Mucosta) and based on the accumulating evidence in relation to their favorable effects on the tear film and ocular surface epithelium, 5 – 31 we took further steps to emphasize the importance of a stable tear film of dry eye patients in Asia. These two eye drops work to increase tear breakup time by increasing aqueous and or mucin components to the ocular surface.…”

mentioning

confidence: 99%

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

Ohta¹,

Yokoi²,

Watanabe³

et al. 2020

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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: The 2017 consensus report of the Asia Dry Eye Society (ADES) on the definition and diagnosis of dry eyes described dry eye disease as “Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage.” The report emphasized the instability of tear film and the importance of visual dysfunction in association with dry eyes, highlighting the importance of the evaluation of tear film stability. This report also discussed the concept of tear film–oriented therapy, which stemmed from the definition, and which is centered on provision of insufficient components in each tear film layer and ocular surface epithelium. The current ADES report proposes a simple classification of dry eyes based on the concept of tear film–oriented diagnosis and suggests that there are three types of dry eye: aqueous-deficient, decreased wettability, and increased evaporation. It is suggested that these three types respectively coincide with the problems of each layer: aqueous, membrane-associated mucins, and lipid/secretory mucin. Although each component cannot be quantitatively evaluated with the current technology, a practical diagnosis based on the patterns of fluorescein breakup is recommended. The Asia Dry Eye Society classification report suggests that for a practical use of the definition, diagnostic criteria and classification system should be integrated and be simple to use. The classification system proposed by ADES is a straightforward tool and simple to use, only through use of fluorescein, which is available even to non-dry eye specialists, and which is believed to contribute to an effective diagnosis and treatment of dry eyes.

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mentioning

confidence: 99%

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

Ohta¹,

Yokoi²,

Watanabe³

et al. 2020

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

Self Cite

124

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“…The tear film is a remarkable factor of post-operative visual performance after phacoemulsification [34][35][36][37][38][39][40] which also needs to be considered. Tear film instability and inappropriate quality is known to adversely affect image quality [45,46].…”

Section: Plos Onementioning

confidence: 99%

“…The quality of the tear film has a prominently important role in the post-operative outcome after phacoemulsification with IOL implantation. Post-operative use of artificial tears [34,35], diquafosol ophthalmic solution 3% [36,37] and bandage contact lens [38] was found to improve the quality of the tear film in pseudophakic patients. Dry eye was reported to be the second or third most important reason of dissatisfaction after multifocal intraocular lens implantation [39,40].…”

Section: Introductionmentioning

confidence: 95%

The assessment of the impact of glistening on visual performance in relation to tear film quality

Argay

Vámosi

2020

PLoS ONE

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Background The aim of our case control study was to evaluate the impact of glistening and tear film quality on visual performance after implantation of two different hydrophobic acrylic intraocular lenses (IOLs). Materials and methods In our retrospective study we included cataract patients operated between January 1, 2011 and December 31, 2012, with follow-up controls between January 2016 and December 2019. Z-Flex 860FAB (Medicontur) and AcrySof IQ SN60WF (Alcon) monofocal IOLs were implanted during standard phacoemulsification. Best corrected distance visual acuity (BCDVA) and contrast sensitivity were monitored over the post-operative period of up to 6 years. Glistening was evaluated semi-quantitatively with slit-lamp biomicroscopy and quantitatively using Pentacam HR (Oculus). Using HD Analyzer OQAS (Visiometrics), total intraocular light diffusion was interpreted with the objective scatter index (OSI) and tear film quality was evaluated with the tear film related objective scatter index (TF-OSI). Results 26 eyes implanted with the Z-Flex and 25 eyes with the AcrySof IQ IOLs were included in the analysis. The slit-lamp evaluation of patients with the Z-Flex IOL (0.57 ± 0.60) revealed significantly less glistening (p<0.0001), compared to the AcrySof IQ group (1.82 ± 0.90), and these observations were confirmed by the Pentacam HR analyses, as well (Z-Flex group: 35.1 ± 1.63, Acrysof IQ: 39.6 ± 3.69, p<0.0001). TF-OSI differed between the two sets of patients remarkably (1.53 ± 1.03 vs. 2.51 ± 1.76 for AcrySof IQ and Z-Flex groups, respectively, p = 0.043). Both groups of patients provided similar results of BCDVA and contrast sensitivity. Conclusion Glistening and tear film quality both contribute to visual performance outcomes after cataract surgery. In our study the advantage of less glistening in the Z-Flex IOL might have been

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“…The postoperative use of cyclosporine 0.05% topical eye drops has led to improvement in dry eye symptoms and visual quality following cataract surgery 11,12 . Recently, diquafosol sodium ophthalmic solution has also been used for the management of DED after cataract surgery 2,5,6,13 . Diquafosol is a dinucleotide derivative and functions as an agonist of the purinergic P2Y 2 receptor 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Diquafosol is known to stimulate not only mucin secretion from goblet cells but also water secretion from conjunctival epithelial cells and the accessory lacrimal glands 14,15 . Studies have shown that diquafosol is very effective in treating and alleviating symptoms of DED after cataract surgery 2,5,6,13 . Furthermore, several studies have shown that topical diquafosol is more effective for managing DED after cataract surgery than artificial tears 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial

Jun

Choi

Lee

et al. 2019

Sci Rep

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Dry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We investigated the efficacy of preservative-free diquafosol in patients with pre-existing DED after cataract surgery. We divided subjects who were diagnosed with DED and scheduled to undergo cataract surgery, into 3 groups (preservative-free diquafosol, group 1; preservative-containing diquafosol, group 2; preservative-free hyaluronate, group 3), and each eye drops was administered 6 times daily after surgery. Tear break up time (TBUT), Ocular Surface Disease Index (OSDI), corneal staining score, lid margin abnormality, and meibum quality improved over time in group 1. Groups 1 and 2 had significantly superior TBUT, meibomian gland dysfunction grade, and meibomian gland expressibility throughout the study period than group 3. Meibum quality of group 1 was significantly better than group 2 at 1 and 3 months after surgery. Preservative-free diquafosol showed better efficacy in treating DED after cataract surgery than preservative-containing diquafosol or preservative-free hyaluronate. Preservative-free diquafosol may serve as a reliable option for the management of patients with pre-existing DED after phacoemulsification.

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Effect of diquafosol three per cent ophthalmic solution on tear film and corneal aberrations after cataract surgery

Abstract: Peri-operative application of diquafosol three per cent ophthalmic solution may prevent dry eye-related ocular surface changes accompanied by improvement of ocular symptom. No definite changes in corneal aberrations were noted.

Cited by 14 publications

References 27 publications

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

The assessment of the impact of glistening on visual performance in relation to tear film quality

Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial

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