Effect of Diffusivity on the Transport of Drug Eluted from Drug-Eluting Stent

Abstract

A model for investigating the drug transport into a porous arterial wall from a drugeluting stent is developed. Under the assumption of Darcy flow in the tissue, a model based on a two-dimensional unsteady convection-diffusion equation is derived where the relative roles of the convective and diffusive transport are characterised by a Peclet number, Pe. The Marker and Cell method is developed in Cartesian co-ordinate system in order to tackle the governing equations of motion representing interstitial flow and the transport of drug within a porous arterial wall in a stent-based drug delivery. The effects of Peclet number on drug transport are quantitatively investigated graphically. The present study clearly predicts that with an increase in Peclet number, there occurs a reduction in the drug deposition within the arterial wall. This observation is consistent with those of previous investigations available in the literature.

Computational Modelling of Three-phase Stent-based Delivery

“…14, 15 A number of experimental and numerical studies on DES have been published in recent years to address such issues as longevity and safety. 3,11, [16][17][18][19][20][21][22] Since binding of the ligand to the cell surface receptors has been amenable to direct experimental investigation for roughly the past three decades, 23,24 a sincere attempt has also been made to take into account the binding event that occurs on the cell surface. However, no such attempt has been made to consider the aspects of trafficking process, cell signaling or receptor mobility.…”