Effect of differently induced plasma norepinephrine increments on norepinephrine sulfate formation

Strobel, Günther; Haussmann, Rainer; Bärtsch, Peter

doi:10.1016/s0024-3205(02)01620-x

Cited by 1 publication

(1 citation statement)

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“…Both in vivo and in vitro investigations have shown that NE can trigger the release of PGE 2 [ 27 ]. It has also been reported that a major part of NE is sulfoconjugated in blood or at sites easily accessible from blood [ 29 ]. The catecholamine-releasing compound tyramine, which is derived from tyrosine and acts as a neurotransmitter via a G protein-coupled receptor, is metabolized by the enzyme monoamine oxidase.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics of the Antipyretic Effects of Bubali Cornu (Water Buffalo Horn) in Rats

et al. 2016

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Bubali Cornu (water buffalo horn, WBH) has been used for thousands of years in traditional Chinese medicine (TCM) as an effective treatment for heat. In the present study, we have carried out a metabolomics profiling study on plasma and urine samples to explore potential biomarkers and determine how WBH exerts its antipyretic effects in yeast-induced pyrexia at a metabolomic level. Ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS), together with multivariate statistical analysis, was used to detect and identify potential biomarkers associated with pyrexia and with WBH treatment. In total, sixteen endogenous metabolites were identified in plasma samples and twenty-one metabolites were detected in urine samples. The biomarkers identified in this study, using metabolic pathway analysis (MetPA), are involved in glycerophospholipid, arachidonic acid, amino acid, sphingolipid, and purine metabolism, all of which are disturbed in rats with pyrexia. As a result, WBH affect arachidonic acid metabolism and oxidative stress in yeast-induced pyrexia rats chiefly. The present study determines the important substances underlying the antipyretic efficacy of WBH at a metabolic level. It might pave the way for further investigations into the mechanisms of action of other animal horn-derived traditional Chinese medicines (TCMs).

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Section: Discussionmentioning

confidence: 99%