Effect of Different Running Exercise Modalities on Post-Exercise Oxidative Stress Markers in Trained Athletes

Souissi, Wajdi; Bouzid, Mohamed; Farjallah, Mohamed Amine; Mahmoud, Lobna Ben; Boudaya, M.; Engel, Florian; Sahnoun, Zouheir

doi:10.3390/ijerph17103729

Cited by 25 publications

(23 citation statements)

References 39 publications

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“…In this study, plasma MDA levels were analyzed to confirm the changes in OS according to exercise intensity. The results of the present study showed that plasma MDA levels significantly increase in response to exercise regardless to its intensity (MI or HI), which agrees with previous studies [ 24 , 26 ] that reported a significant increase in plasma MDA levels after acute exercise. This phenomenon is believed to result from free radicals produced by exercise that will in turn promote lipid peroxidation.…”

Section: Discussionsupporting

confidence: 93%

“…This phenomenon is believed to result from free radicals produced by exercise that will in turn promote lipid peroxidation. Souissi et al [ 26 ] reported that plasma MDA levels increase significantly after intermittent running exercise at 75% of maximal aerobic speed. Moreover, Spirlandeli et al [ 24 ] showed that plasma MDA levels were significantly increased in eight healthy and well-trained males upon acute exercise intervention, as determined by three different methods (high-performance liquid chromatography, thiobarbituric acid reactive species, and 1-methyl-2-phenylindole analyses), which suggested that MDA could be a valuable biomarker of lipid peroxidation following acute exercise.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers

Cho

Chung²,

Yoon

et al. 2022

IJERPH

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Exercise can induce anti-inflammatory and antioxidant effects, for which regulation of sirtuins (SIRTs) may be a major consideration for exercise prescription. The purpose of this study was to investigate the effects of acute aerobic exercise, in particular its intensity, on systemic oxidative stress, inflammatory responses, and SIRT levels. Twenty healthy, untrained males were recruited and randomly assigned to moderate-intensity (MI, 65% VO2max, n = 10) and high-intensity (HI, 85% VO2max, n = 10) exercise. Blood samples were obtained pre-, immediately post-, and 1 h post-exercise for measurements of malonaldehyde (MDA), superoxide dis-mutase (SOD), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, SIRT-1, SIRT-2, and SIRT-3. Overall, MDA, SOD, IL-6, SIRT-1, and SIRT-3 levels were significantly increased at post-exercise compared with pre-exercise regardless of exercise intensity (p < 0.05). The HI group had significantly higher MDA, SOD, and IL-6 levels than the MI group at post-exercise (p < 0.05), whereas no significant differences were observed in the IL-1β, TNF-α, and SIRT-2 levels (p > 0.05). Altogether, these findings suggest that exercise-induced oxidative stress and inflammatory responses may be dependent on exercise intensity. Moreover, activation of inflammatory cytokines and SIRT family members may be dependent on the intensity of the exercise.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers

Cho

Chung²,

Yoon

et al. 2022

IJERPH

View full text Add to dashboard Cite

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“…One-way-ANOVA test results revealed that there was no significant difference in the mean MDA levels in each group (p>0.05). These results are in line with the results of research conducted by Souissi et al 18 concluded that there was an increase in MDA levels in athletes after carrying out physical activity in the form of running. However, these results differ from the results of a study conducted by Azizbeigi et al 19 concluded that there was a significant decrease in malondialdehyde levels after the resistance training intervention for 8 weeks.…”

Section: Discussionsupporting

confidence: 92%

Ascorbic Acid Drink after Submaximal Physical Activity can Maintain the Superoxide Dismutase Levels in East Java Student Regiment

Wibawa,

Zainul Arifin,

Herawati

2021

Indian Journal of Forensic Medicine & Toxicology

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Objective -This study aimed to analyze the effect of ascorbic acid after submaximal physical activity on reducing levels of malondialdehyde (MDA) and increasing levels of superoxide dismutase (SOD) to Student Regiment in East Java.Methods -This study was a true experiment with a randomized control group posttest-only design used 28 male subjects aged 19-23 years with body mass index (BMI) 18.5-24.9 kg/m 2 , and randomly divided into four groups. Namely G 1 (n=7, control without submaximal physical activity+placebo), G 2 (n=7, submaximal physical activity+placebo), G 3 (n=7, submaximal physical activity+AA 500 mg), and G 4 (n=7, submaximal physical activity+AA 1,000 mg). The submaximal physical activity was 2.400 meters running in 12 minutes or when the 60-70% of HRmax achieved. The drinks containing 500 mg and 1.000 mg ascorbic acid (AA) for G3 and G4 was given after exercise test. Measurement of serum MDA and SOD used the Thiobarbituric Acid Reactive Substances (TBARs) method. The data was statistical analyzed using SPSS software with a significant level (p<0.05).Results -The results of MDA levels showed in G 1 (308.18±61.81 ng/mL), G 2 (338.42±125.78 ng/mL), G 3 (290.54±69.18 ng/mL), G 4 (279.83±39.10 ng/mL) and there was no significantly difference among groups (p=0.557). The mean levels of SOD was significant among groups ((p=0.000), and the SOD level in each group was G 1 (23.19±0.77 units/mL), G 2 (24.81±0.87 units/mL), G 3 (25.27±0.79 units/mL), G 4 (25.57±0.47 units/mL). Conclusion -It can be concluded that 500 mg and 1.000 mg ascorbic acid drinks after submaximal physical activity can increase SOD levels of students regiment in East Java. Ascorbic acid drink may maintain the SOD level by lessening the use of antioxidant endogen and it may also increase the SOD level, however futher research is needed to be conducted to figure out the mechamism.

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“…In our study we also observed the enhanced amount of AOPP (M30, M120, F30 groups) and AGE (F30 group), i.e., the products of non-enzymatic oxidation and glycation of proteins. Importantly, exercise modality could determine the level of oxidative stress since intermittent running attenuated elevation in AOPP as compared with continuous exercise due to better repair capacities [65]. Products of oxidation and glycation of proteins also enhance the synthesis of pro-inflammatory cytokines/chemokines by inducing NOX activity or stimulating the receptor for advanced glycation end products (RAGE).…”

Section: Discussionmentioning

confidence: 99%

Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

Supruniuk

Maciejczyk

Górski

et al. 2020

IJMS

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Both positive and negative aspects of sport performance are currently considered. The aim of our study was to determine time- and intensity-dependent effects of a single exercise bout on redox and inflammatory status. The experiment was performed on 40 male Wistar rats subjected to treadmill running for 30 min with the speed of 18 m/min (M30) or 28 m/min (F30), or for 2 h with the speed of 18 m/min (M120). Immunoenzymatic and spectrophotometric methods were applied to assess the levels of pro-inflammatory and anti-inflammatory cytokines, chemokines, growth factors, the antioxidant barrier, redox status, oxidative damage products, nitrosative stress, and their relationships with plasma non-esterified fatty acids. Treadmill running caused a reduction in the content of monocyte chemoattractant protein-1 (MCP1) and nitric oxide (M30, M120, F30 groups) as well as macrophage inflammatory protein-1α (MIP-1α) and regulated on activation, normal T-cell expressed and secreted (RANTES) (M30, F30 groups). We also demonstrated an increase in catalase activity as well as higher levels of reduced glutathione, advanced oxidation protein products, lipid hydroperoxides, malondialdehyde (M30, M120, F30 groups), and advanced glycation end products (F30 group). The presented findings showed the activation of antioxidative defense in response to increased reactive oxygen species’ production after a single bout of exercise, but it did not prevent oxidative damage of macromolecules.

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Effect of Different Running Exercise Modalities on Post-Exercise Oxidative Stress Markers in Trained Athletes

Cited by 25 publications

References 39 publications

Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers

Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers

Ascorbic Acid Drink after Submaximal Physical Activity can Maintain the Superoxide Dismutase Levels in East Java Student Regiment

Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

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