Effect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 activity in healthy people

Solak, Zeynep Aytemur; Kabaroğlu, Ceyda; Çok, Gürsel; Parildar, Zuhal; Bayındır, Ülkü; Özmen, Dilek; Bayındır, Oya

doi:10.1007/s10238-005-0072-5

Cited by 85 publications

(61 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Guentsch et al (23) and Akalın et al (24) reported that MDA levels increased in the saliva of smokers versus nonsmokers and these findings were in concordance with those reported by some previous studies in venous blood erythrocyte/serum/plasma (22,(25)(26)(27). Our findings support these results.…”

Section: Discussionsupporting

confidence: 93%

A comparison of the generation of free radicals in saliva of active and passive smokers

Demirtaş¹,

Şenel²,

Yüksel³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

The erosion/incision patterns of radiometrically well-constrained volcanic rocks provide excellent markers for revealing the landscape evolution. The Central Anatolian High Plateau represents an uplifted area that reaches up to 1500 m above sea level and includes the Cappadocian Volcanic Province (CVP). The CVP is composed of horizontally emplaced Neogene-Quaternary ignimbrites intercalated with lava flows and epiclastic continental sediments. River incision rates have been calculated using the morphological/ paleoaltimetric features of radiometrically well-constrained volcanic units in the area. Starting from 10 Ma until 5 Ma, there was no major erosion or incision. The morphology, uplift rate, and incision rates of the CVP reveal that the onset of uplift is post 8 Ma and incision started after 5 Ma. Between 5 and 2.5 Ma, the incision rate is computed as 0.12 mm/year, whereas, in the last 2.5 Ma, the incision rate slowed down to 0.04 mm/year.

show abstract

Section: Discussionsupporting

confidence: 93%

A comparison of the generation of free radicals in saliva of active and passive smokers

Demirtaş¹,

Şenel²,

Yüksel³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…In non-schizophrenic smokers, MDA also increases as a product of this oxidative stress (Altuntas et al, 2002;Ozguner et al, 2005;Solak et al, 2005). However, the lower MDA levels in schizophrenic smokers suggests that tobacco smoke increases the activity of these antioxidant enzymes more than is needed to simply counteract the peroxidation effects of tobacco smoke.…”

Section: Discussionmentioning

confidence: 99%

“…Nicotine in quantities similar to those in cigarette smoke can induce oxidative stress, as shown in vitro and in vivo (Solak et al, 2005). Increased lipid peroxidation occurs in Chinese hamster ovary cells (Yildiz et al, 1998) and pancreatic tissue of rats (Wetscher et al, 1995) that are incubated with nicotine.…”

Section: Introductionmentioning

confidence: 96%

Nicotine Dependence, Symptoms and Oxidative Stress in Male Patients with Schizophrenia

Zhang

Tan

Zhou

et al. 2007

Neuropsychopharmacol

View full text Add to dashboard Cite

The high rate of smoking in schizophrenia may reflect patients' attempts to reduce the side effects of antipsychotic medications, and one mechanism for this reduction may be a reduction in oxidative stress and free radical-mediated brain damage that may contribute to schizophrenic symptoms and to complications of its treatment. Symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS), side effects were assessed with the Simpson and Angus Rating Scale (SAS), and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities were measured in plasma. All of these measures were compared in 130 male inpatients with DSM-IV schizophrenia: 104 smokers and 26 non-smokers. The results showed that the positive PANSS symptoms were lower in smokers than non-smokers (14.5 vs 17.5), while the negative symptoms were lower in those who smoked more cigarettes (r ¼ À0.23). The SAS showed no differences. The CAT activity was correlated with both GSH-Px and SOD activities. Of the three enzymes only the CAT activity was significantly higher in smokers than non-smokers (2.9 vs 1.6 U/ml), but greater SOD activity correlated more cigarettes smoked (r ¼ 0.24). Consistent with some protection against oxidative stress, MDA also was significantly lower in smokers than non-smokers (9.2 vs 14.4 nmol/ml). The fewer positive symptoms in smokers and fewer negative symptoms in those who smoked more cigarettes may be a selection bias, but appears to be associated with decreased oxidative stress and lipid peroxidation in schizophrenics who smoke tobacco.

show abstract

“…As dyslipidemia, including hypertriglyceridemia and hypo-HDL-cholesterolemia, is important in the pathogenesis of atherosclerosis, smoking may accelerate the development of CVDs indirectly via its detrimental effects on serum lipid profiles. Smoking was also reported to induce qualitative changes in serum lipids (28)(29)(30). Excess free radicals and oxidants present in cigarette smoke, as well as endogenously produced oxidants and radicals, enhance the pro-oxidative environment (6,29).…”

Section: Discussionmentioning

confidence: 99%

“…Smoking was also reported to induce qualitative changes in serum lipids (28)(29)(30). Excess free radicals and oxidants present in cigarette smoke, as well as endogenously produced oxidants and radicals, enhance the pro-oxidative environment (6,29). It was suggested that peroxynitrite is significant in the oxidative modification of plasma LDL induced by smoking (30).…”

Section: Discussionmentioning

confidence: 99%

Association of smoking with prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals

et al. 2017

View full text Add to dashboard Cite

Abstract.Smoking is a significant risk factor for cardiovascular diseases (CVDs). Given that certain common pathologies, including hypertension, dyslipidemia and type 2 diabetes mellitus, are major risk factors for CVDs, the association of smoking with CVDs may be attributable, at least in part, to its effects on common diseases. The aim of the present study was to determine the association of smoking with the prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals. The study included 5,959 subjects (1,302 current smokers, 1,418 past smokers and 3,239 nonsmokers) recruited to the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases. Various metabolic parameters and prevalence of common diseases were compared between smokers and nonsmokers using multivariable regression or logistic regression analysis with adjustments for age. Analysis indicated significantly higher serum concentrations of triglycerides and lower concentrations of high-density lipoprotein (HDL)-cholesterol in current smokers compared with nonsmokers in men and women. Serum concentrations of creatinine and systolic blood pressure were significantly lower and estimated glomerular filtration rate was higher in male current smokers. In addition, body weight was higher in female current smokers. In multivariable logistic regression analysis, smoking was significantly associated with the prevalence of dyslipidemia [P=6.3x10 -10 ;odds ratio (OR), 1.81], hypertriglyceridemia (P=2.3x10-20

show abstract

Effect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 activity in healthy people

Cited by 85 publications

References 37 publications

A comparison of the generation of free radicals in saliva of active and passive smokers

A comparison of the generation of free radicals in saliva of active and passive smokers

Nicotine Dependence, Symptoms and Oxidative Stress in Male Patients with Schizophrenia

Association of smoking with prevalence of common diseases and metabolic abnormalities in community-dwelling Japanese individuals

Contact Info

Product

Resources

About