Effect of Different Culture Systems and 3, 5, 3'-Triiodothyronine/Follicle-Stimulating Hormone on Preantral Follicle Development in Mice

Zhang, Cheng; Wang, Xiaoxia; Wang, Zhengpin; Niu, Wanbao; Zhu, Beiwei; Xia, Guoliang

doi:10.1371/journal.pone.0061947

Cited by 28 publications

(24 citation statements)

References 59 publications

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“…An in vivo study using propylthiouracil-induced hypothyroid rats revealed that hypothyroidism may impact ovarian folliculogenesis, granulosa cell differentiation and steroidogenesis without affecting proliferation [22]. Thyroid hormone plays an important role in follicular development [23,24]. In addition, TSH directly suppressed follicle development in a concentration-dependent manner [25].…”

Section: Discussionmentioning

confidence: 99%

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Kuroda

Uchida

Saki

et al. 2014

J Assist Reprod Genet

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Purpose Thyroid dysfunction and autoimmune thyroiditis are associated with fertility in women of reproductive age. AntiMüllerian hormone (AMH), a known biomarker of ovarian function, may be affected by impaired thyroid function; however, the relationship between AMH and thyroid hormone has not been elucidated. Methods In this case-control study, to identify the impact of thyroid hormone on ovarian reserve, we recruited 67 consecutive Japanese infertile patients and 27 normal fertile women aged 30-39 years without impact factors on thyroid and ovarian functions between 2012 and 2013. We assessed patient age, BMI and AMH, prolactin, TSH and FT4 levels of all study participations as independent variables. To evaluate the relationship between AMH and thyroid hormone, we matched patients by age and body mass index as confounding factors using 1:1 matching for statistical analysis of healthy fertile women and infertile patients and obtained 23 pairs. Then, independent variables were subjected to multiple regression analysis.Results Multiple regression analysis showed that both thyroid-stimulating hormone (TSH) levels and patient age were negatively correlated with AMH levels in infertile patients (patient age and TSH: standardized partial regression coefficient (β), −0.534 and −0.361; p=0.003 and 0.036, respectively), but not in normal fertile women. Conclusions AMH levels were inversely correlated with TSH levels in infertile women of reproductive age.

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Section: Discussionmentioning

confidence: 99%

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Kuroda

Uchida

Saki

et al. 2014

J Assist Reprod Genet

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“…14, 15 Mehendale et al reported the follicle development suppression by TSH in a concentration dependent basis. 16 Though our study findings are well in support of previous findings, it has got some limitations.…”

Section: Discussionmentioning

confidence: 99%

Comparisons and correlations of anti mullerian hormone and thyroid stimulating hormones in fertile and subfertile women

2020

IJCBR

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Introduction and Objectives: Thyroid dysfunction and autoimmunity are related to adverse impact on fertility in reproductive aged women. Anti-Mullerian hormone (AMH), biomarker of 'ovarian age' may be affected by impaired thyroid function, but the relationship between AMH and thyroid hormone is unclear. The aim of this study was to determine the impact of thyroid stimulating hormone (TSH) on AMH levels. Materials and Methods:In this case-control study, to identify the impact of thyroid hormone on ovarian reserve, we recruited 30 consecutive Indian infertile patients and 30 normal fertile women aged 19 -39 years without impact factors on thyroid and ovarian functions between April 2017 and September 2017. We assessed patient age, AMH, and TSH levels of all study participants as independent variables. We also evaluated the correlations between AMH and TSH in our study groups. In addition, independent variables were subjected to multiple regression analysis. Results: Our results showed significant changes in AMH and TSH between groups. The increased TSH status in the subfertile cases was inversely correlated with the TSH levels (r=-0.44, p<0.05). The TSH levels were independently associated with the decreased AMH levels in infertile patients (β= -0.82 p = < 0.0001). Conclusion: AMH levels were inversely correlated with TSH levels in infertile women of reproductive age. Further studies with large sample size are warranted in future.

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“…Azaline B treatment also eliminates the surgical stress, which may adversely affect follicular functions in the long run, thus compromising follicular response to gonadotropins. Evidence suggests that T3 enhances follicular response to FSH leading to increased development of preantral follicles in mice (Zhang et al, 2013). T3 also prevents granulosa cell apoptosis following chemotherapy (Verga Falzacappa et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Effect of azaline B on follicular development and functions in the hamster

Chakraborty¹,

Roy²

2015

Molecular and Cellular Endocrinology

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The usefulness of azaline B, a GnRH antagonist, in suppressing gonadotropin secretion in the golden hamster was examined by examining follicular development, steroidogenesis and expression of steroidogenic enzymes. Serum levels of P and E declined significantly, while FSH or LH was undetectable in azaline B-treated hamsters. FSH significantly increased serum E levels, whereas LH upregulated serum P levels. The formation of antral follicles ceased in azaline-treated hamsters, but was reversed by FSH with or without LH supplement. FSH also activated the primordial follicle pool resulting in increased formation of primary and preantral follicles. Further, an increasing trend in the formation of preantral follicles in response to E or E + P, and the formation of antral follicles in response to E + P treatment was evident. The level of Cyp11a1 mRNA increased markedly in LH− or LH + FSH-treated hamsters, whereas FSH with or without LH upregulated Cyp17a1, Cyp19a1 and Fshr mRNA expression. E without or with P also upregulated ovarian Cyp19a1 mRNA expression. The expression of enzyme protein corroborated the mRNA data. In summary, azaline B is an efficient GnRH antagonist in the hamster, and will be useful in studying the selective effect of gonadotropins on ovarian functions without disrupting the physiological functions of other hormones in ovarian cells.

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Effect of Different Culture Systems and 3, 5, 3'-Triiodothyronine/Follicle-Stimulating Hormone on Preantral Follicle Development in Mice

Cited by 28 publications

References 59 publications

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age

Comparisons and correlations of anti mullerian hormone and thyroid stimulating hormones in fertile and subfertile women

Effect of azaline B on follicular development and functions in the hamster

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