Comparisons and correlations of anti mullerian hormone and thyroid stimulating hormones in fertile and subfertile women

Abstract

Introduction and Objectives: Thyroid dysfunction and autoimmunity are related to adverse impact on fertility in reproductive aged women. Anti-Mullerian hormone (AMH), biomarker of 'ovarian age' may be affected by impaired thyroid function, but the relationship between AMH and thyroid hormone is unclear. The aim of this study was to determine the impact of thyroid stimulating hormone (TSH) on AMH levels. Materials and Methods:In this case-control study, to identify the impact of thyroid hormone on ovarian reserve, we recruited 30 consecutive Indian infertile patients and 30 normal fertile women aged 19 -39 years without impact factors on thyroid and ovarian functions between April 2017 and September 2017. We assessed patient age, AMH, and TSH levels of all study participants as independent variables. We also evaluated the correlations between AMH and TSH in our study groups. In addition, independent variables were subjected to multiple regression analysis. Results: Our results showed significant changes in AMH and TSH between groups. The increased TSH status in the subfertile cases was inversely correlated with the TSH levels (r=-0.44, p<0.05). The TSH levels were independently associated with the decreased AMH levels in infertile patients (β= -0.82 p = < 0.0001). Conclusion: AMH levels were inversely correlated with TSH levels in infertile women of reproductive age. Further studies with large sample size are warranted in future.