Effect of different angiotensin-converting-enzyme inhibitors on mortality among elderly patients with congestive heart failure

Pilote, Louise; Abrahamowicz, Michał; Eisenberg, Mark J.; Humphries, Karin H.; Behlouli, Hassan; Tu, Jack V.

doi:10.1503/cmaj.060068

Cited by 59 publications

(37 citation statements)

References 30 publications

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“…29,33 Scrutiny of this shift is warranted, particularly where a class effect has been demonstrated, since older, more established and hence less expensive medications may be the most cost-effective option. 34,35 Between 1996 and 2006, an average of 88 new patented drugs were made available annually in Canada, with only 20%-25% of these representing new active substances. 33 This means that many of the new brand name medications may not represent major therapeutic advances.…”

Section: Discussionmentioning

confidence: 99%

“…2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] However, whether these drugs should be replacing older, established medications is debatable. 34,35 The recommendations in hypertension guidelines, which have traditionally favoured relatively cheaper diuretics and β-blockers as first-line therapies, have been revised over the years to include more expensive ACE inhibitors, angiotensin-receptor blockers and calcium antagonists as possible first-line agents. There is also an increasing trend for recommending combination therapy if there is only a partial response to monotherapy, whereas previous recommendations suggested dose escalation or switching to an alternative monotherapy if the initial treatment was only partially effective.…”

Section: Discussionmentioning

confidence: 99%

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Long-term trends in use of and expenditures for cardiovascular medications in Canada

Jackevicius

Cox²,

Carreon³

et al. 2009

Canadian Medical Association Journal

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long-term trends in use of and expenditures for cardiovascular medications in Canada

Jackevicius

Cox²,

Carreon³

et al. 2009

Canadian Medical Association Journal

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“…18 Golongan ACE inhibitor lainnya seperti lisinopril, fosinopril, quinapril, perindopril, dan cilazapril memiliki kekuatan yang sama dengan ramipril dalam menurunkan risiko kematian akibat penyakit kardiovaskular. 19 Misalnya, penggunaan perindopril pada pasien hipertensi yang disertai dengan penyakit jantung koroner dan Left Ventricular Ejection Fraction (LVEF ≥ 40%) dapat mengurangi risiko primary endpoint sebesar 16% (kematian karena penyakit kardiovaskular, infark miokard dan cardiac arrest serta LVEF menjadi < 40%. 8 Penggunaan perindopril juga dapat mengurangi risiko penyakit jantung koroner sebesar 20%.…”

Section: Pembahasanunclassified

Persistensi Penggunaan Obat Antihipertensi pada Pasien Hipertensi Rawat Jalan

Nurmainah

Fudholi

Dwiprahasto

2013

Kesmas: National Public Health Journal

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AbstrakPersistensi penggunaan obat antihipertensi pada pasien hipertensi sangat diperlukan mengingat hasil utama terapi hipertensi adalah mencegah kejadian penyakit kardiovaskular seperti infark miokard, dan stroke yang berujung pada kematian. Penelitian ini bertujuan mengetahui pengaruh jenis terapi dan jenis obat antihipertensi terhadap persistensi. Penelitian ini menggunakan desain studi kohort retrospektif dan menggunakan sumber data sekunder pasien hipertensi rawat jalan peserta asuransi kesehatan PT Askes di RSUD Panembahan Senopati Bantul. Metode pengukuran persistensi adalah metode the gaps between refill dengan tenggang waktu pengambilan obat selama 30 hari. Data dianalisis menggunakan uji kai kuadrat, Kaplan-Meier, dan Cox regression. Jumlah subjek yang ikut dalam penelitian ini adalah 304 pasien hipertensi yang menggunakan obat antihipertensi pertama kali (tanggal indeks diagnosis 1 Juli 2007 hingga 31 Desember 2008). Setelah pengamatan 4,5 tahun, hampir separuh subjek yang mendapat monoterapi (57,6%) dan kombinasi terapi (53,8%) tidak persisten menggunakan obat antihipertensi. Ketidakpersistenan penggunaan obat antihipertensi lebih besar pada kelompok monoterapi daripada kelompok kombinasi, tetapi perbedaan tersebut tidak signifikan (RR = 0,94; 95% CI = 0,73 _ 1,21). Penggunakan diuretik (85,7%) dan kombinasi obat diuretik + ACE inhibitor (84,6%) cenderung tidak persisten dibandingkan subjek yang menggunakan ACE inhibitor (58,4%). Perbedaan ini bermakna secara statistik (RR = 1,47; 95% CI = 1,05 _ 2,01 dan RR = 1,45; 95% CI = 1,10 _ 1,91). Persistensi dipengaruhi oleh jenis obat antihipertensi yang digunakan, yaitu ACE inhibitor. Kata kunci: ACE inhibitor, hipertensi, persistensi AbstractPersistence of the use of antihypertensive drugs in hypertensive patients greatly needed. Considering the primary outcome of treatment for hypertension is to reduce or prevent the occurrence of cardiovascular events such as myocardial infarction, stroke resulting in the risk of death. This Persistensi Penggunaan Obat Antihipertensi pada Pasien Hipertensi Rawat Jalan Persistence of Antihypertensive Drugs among Outpatient with HypertensionNurmainah* Ahmad Fudholi** Iwan Dwiprahasto*** study aims to determine whether persistence is influenced by the type of treatment or type of antihypertensive drugs. This study was designed with retrospective cohort study using database of prescribing claimed of subjects under health insurance (PT Askes) in Panembahan Senopati hospitals using antihypertensive drugs. Persistency measurement method used is the method of the gaps between refilling. The grace period taking the drug for 30 days. Further data were analyzed using the chi square test, Kaplan _ Meier, and Cox regression. This cohort study involving 304 patients using antihypertensive medications first (index diagnosis 1 July 2007 until 31 December 2008). After observation for 4,5 years found almost half of the subjects receive monotherapy (57,6%) or combination therapy (53,8%) are not persistent in the use of antihypertensive m...

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“…LOD = 3(SD/a) …………………….. (1) LOQ = 10(SD/a) …………………… (2) where SD = standard deviation of the intercept and a = mean slope obtained from the calibration plot.…”

Section: Limit Of Detection (Lod) and Of Quantitation (Loq)mentioning

confidence: 99%

“…ACE inhibitors are used to treat hypertension and congestive heart failure. They act by lowering the production of angiotensin II, thereby relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passage ways [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

A Spectrophotometric Method for the Determination of Ramipril in Solid Dosage Forms

Afieroho¹,

Okorie²,

Okonkwo³

2012

Trop. J. Pharm Res

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Effect of different angiotensin-converting-enzyme inhibitors on mortality among elderly patients with congestive heart failure

Cited by 59 publications

References 30 publications

Long-term trends in use of and expenditures for cardiovascular medications in Canada

Long-term trends in use of and expenditures for cardiovascular medications in Canada

Persistensi Penggunaan Obat Antihipertensi pada Pasien Hipertensi Rawat Jalan

A Spectrophotometric Method for the Determination of Ramipril in Solid Dosage Forms

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