Long-term trends in use of and expenditures for cardiovascular medications in Canada

Jackevicius, Cynthia A.; Cox, Jafna L.; Carreon, Daisy C.; Tu, Jack V.; Rinfret, Stéphane; So, Derek; Johansen, Helen; Kalavrouziotis, Dimitri; Demers, Virginie; Humphries, Karin H.; Pilote, Louise

doi:10.1503/cmaj.081913

Cited by 23 publications

(30 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…␤-Blocker prescriptions have steadily increased over the last 10 years (16). Their role in hyperkalemia through inhibition of cellular adrenergic receptor-dependent potassium translocation has been extensively studied (17)(18)(19).…”

mentioning

confidence: 99%

Beta-Blockers, Trimethoprim-Sulfamethoxazole, and the Risk of Hyperkalemia Requiring Hospitalization in the Elderly

Weir¹,

Juurlink²,

Gomes³

et al. 2010

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives:The simultaneous use of beta adrenergic receptor blockers (␤-blockers) and trimethoprimsulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia.Design, setting, participants, & measurements: Two nested case-control studies were conducted to examine the association between hospitalization for hyperkalemia and the use of TMP-SMX in older patients receiving ␤-blockers. Linked health administrative records from Ontario, Canada, were used to assemble a cohort of 299,749 ␤-blockers users, aged 66 years or older and capture data regarding medication use and hospital admissions for hyperkalemia.Results: Over the study period from 1994 to 2008, 189 patients in this cohort were hospitalized for hyperkalemia within 14 days of receiving a study antibiotic. Compared with amoxicillin, the use of TMP-SMX was associated with a substantially greater risk of hyperkalemia requiring hospital admission (adjusted odds ratio, 5.1; 95% confidence interval [CI], 2.8 to 9.4). No such risk was identified with ciprofloxacin, norfloxacin, or nitrofurantoin. When dosing was considered, the association was greater at higher doses of TMP-SMX. When the primary analysis was repeated in a cohort of non-␤-blocker users, the risk of hyperkalemia comparing TMP-SMX to amoxicillin was not significantly different from that found among ␤-blocker users.Conclusions: Although TMP-SMX is associated with an increased risk of hyperkalemia in older adults, these findings show no added risk when used in combination with ␤-blockers.

show abstract

mentioning

confidence: 99%

Beta-Blockers, Trimethoprim-Sulfamethoxazole, and the Risk of Hyperkalemia Requiring Hospitalization in the Elderly

Weir¹,

Juurlink²,

Gomes³

et al. 2010

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…1,2 Statins inhibit 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) a rate limiting step in the conversion of HMG-CoA to mevalonate, a precursor for several cellular processes. One result of HMGCR inhibition is reduced cholesterol biosynthesis and coupled with increased LDL-receptor mediated sequestration of LDL, statins are effective at lowering circulating LDL-cholesterol levels.…”

Section: Statins Cholesterol and Inflammationmentioning

confidence: 99%

Is immunity a mechanism contributing to statin-induced diabetes?

Henriksbo¹,

Schertzer

2015

Adipocyte

View full text Add to dashboard Cite

“…The use of angiotensin-receptor blockers grew at an especially high rate, rising by more than 4000% during that period. 1 Such an increase in the use of these agents is not strongly supported by evidence. 1 Although angiotensinreceptor blockers were effective in reducing mortality and morbidity associated with hypertension in one large trial, patients in the control group were not given an angiotensin-converting-enzyme (ACE) inhib itor.…”

mentioning

confidence: 99%

“…1 Such an increase in the use of these agents is not strongly supported by evidence. 1 Although angiotensinreceptor blockers were effective in reducing mortality and morbidity associated with hypertension in one large trial, patients in the control group were not given an angiotensin-converting-enzyme (ACE) inhib itor. 2 Instead, they received atenolol, a β-blocker, a drug class whose use is increasingly being questioned in the management of high blood pressure uncomplicated by prior myocardial infarction, heart failure or tachy arrhythmia.…”

mentioning

confidence: 99%

The potential economic impact of restricted access to angiotensin-receptor blockers

Guertin

Jackevicius²,

Cox³

et al. 2011

Canadian Medical Association Journal

Self Cite

View full text Add to dashboard Cite

Long-term trends in use of and expenditures for cardiovascular medications in Canada

Cited by 23 publications

References 30 publications

Beta-Blockers, Trimethoprim-Sulfamethoxazole, and the Risk of Hyperkalemia Requiring Hospitalization in the Elderly

Beta-Blockers, Trimethoprim-Sulfamethoxazole, and the Risk of Hyperkalemia Requiring Hospitalization in the Elderly

Is immunity a mechanism contributing to statin-induced diabetes?

The potential economic impact of restricted access to angiotensin-receptor blockers

Contact Info

Product

Resources

About