Effect of dietary taurine on cholesterol gallstone formation and tissue cholesterol contents in mice.

Yamanaka, Yumiko; Tsuji, Kiichiro; Ichikawa, Tomio; Nakagawa, Yasue; Kawamura, Mitsuo

doi:10.3177/jnsv.31.225

Cited by 18 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Addition of taurine with cholesterol feeding augmented both serum cholesterol and L.I, in bile significantly in this study. The present findings are interesting and contrary to those of the previous reports (Yamanaka et al 1985;Uenoyama et al 1985). In man, the rate of cholesterol absorption is low in contrast to other species (Turley and Dietschy 1982).…”

Section: Discussioncontrasting

confidence: 57%

“…Our results are similar to those of Hardison and Grundy (1983). In rats and mice, it has been reported that taurine has a hypocholesterolemic effect (Tsuji et al 1979;Yamanaka et al 1985) owing to activation of cholesterol 7a-hydroxylase and successive augmentation of bile acid synthesis. Bile acids are exclusively conjugated with taurine in rats and mice, in contrast to man and rabbit where bile acids conjugate mainly with glycine (Truswell et al 1965).…”

Section: Discussionmentioning

confidence: 99%

“…In rats and mice, administration of taurine markedly depressed a rise in serum and liver cholesterol levels induced by lithogenic diet (Tsuji et al 1979). The development of cholesterol gallstones was inhibited due to a decrease of the hepatic cholesterol content in taurine supplemented mice (Yamanaka et al 1985). However, in the rabbit, taurine produced no significant effect on elevated serum cholesterol level (Herrmann 1959).…”

mentioning

confidence: 89%

See 2 more Smart Citations

Effect of taurine administration on serum lipid and biliary lipid composition in man.

Tanno

Oikawa

Koizumi

et al. 1989

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

(2), 91-99The effect of oral administration of taurine (3.2 g/day, 2 weeks) on the metabolism of lipids and bile acids was studied with healthy humans. Four male subjects were fed taurine. Another five male subjects were administered 1 g of cholesterol daily for two weeks and, at intervals of two weeks, cholesterol and taurine simultaneously. Serum lipoprotein and duodenal bile were analyzed. Oral administration of taurine resulted in the increase of taurine-conjugated bile acids. However, neither serum lipid nor biliary lipid composition was altered. Addition of taurine with cholesterol administration showed elevation of both the serum low density lipoprotein cholesterol level and the lithogenic index in bile. The ratio of glycine-to taurine-conjugated bile acids was changed from 4.1 to 0.63. The ratio of cholic acid/chenodeoxycholic acid was augmented from 0.57 to 0.81. The percentage of taurocholic acid, taurochenodexycholic acid and taurodeoxycholic acid were increased about 4-fold, 2.5-fold and 3-fold, respectively. Our results suggested that taurine administration alone did not influence the serum lipid level although taurine-conjugated bile acids were increased. The taurine intake would increase serum low density lipoprotein cholesterol and biliary cholesterol levels when excessive cholesterol is administered simultaneously.

show abstract

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 89%

See 1 more Smart Citation

Effect of taurine administration on serum lipid and biliary lipid composition in man.

Tanno

Oikawa

Koizumi

et al. 1989

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…The importance of diet in the pathogenesis of GS has been much debated. Information on this issue can be obtained from experimental, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] clinical, [19][20][21][22][23][24][25][26] and epidemiological studies. [27][28][29][30][31][32][33][34][35] These latter studies have mainly investigated symptomatic GS subjects who were aware of having GS or subjects who had been previously submitted to cholecystectomy.…”

mentioning

confidence: 99%

Diet and gallstones in italy: The cross-sectional MICOL results

Attili¹,

Scafato²,

Marchioli³

et al. 1998

Hepatology

View full text Add to dashboard Cite

Fifteen thousand nine hundred ten men and 13,674 women (age, 30-69 years) were enrolled in an epidemiological survey of the general population, between December 1984 and April 1987. Each participant was submitted to ultrasonography (US) of the gallbladder and completed a food-frequency questionnaire, covering 38 food items. A common portion size was identified and subjects were asked how often each item was consumed. Nutrient intake was computed by multiplying the intake frequency and nutrient content per portion for each item, and then by summing the product over all foods. Each nutrient intake was adjusted for energy intake. Alcohol intake was calculated by summing the consumption of wine, beer, and liquor. Having excluded subjects aware of having gallstones (GS) or previously submitted to cholecystectomy (to avoid prothopatic bias), 787 males and 1,014 females with GS and 14,272 males and 10,836 females without GS were available for analysis. Relative risks (RR) of GS were computed by quintiles of nutrient intake. The overnight fasting period was calculated as the difference between the specified time of dinner and the time of the next meal (breakfast or lunch). A significant negative association was found between RR of GS and total energy intake for males ( 2 for trend ‫؍‬ 8.37; P ‫؍‬ .004), fiber intake for females ( 2 ‫؍‬ 5.45; P ‫؍‬ .02), and daily alcohol consumption for males ( 2 ‫؍‬ 10.86; P ‫؍‬ .001). A positive association was observed between RR of GS and carbohydrate ( 2 ‫؍‬ 5.95; P ‫؍‬ .01 for males; 2 ‫؍‬ 9.39; P ‫؍‬ .002 for females) and protein intake only for males ( 2 ‫؍‬ 10.92; P ‫؍‬ .01). Prevalence of GS was higher among subjects who had an overnight fasting period of over 12 hours than subjects with that of less than 12 hours. (RR: 1.35; 95% CI: 1.01-1.80 for males; RR: 1.28; 95% CI: 1.03-1.60 for females). These data do not confirm that high energy intake is associated with an increased risk of GS. Factors protecting against GS comprise: low carbohydrate (males and females) and protein (males) intakes, high fiber (females) and moderate alcohol intake (males) consumption, and a shorter overnight fasting period for both sexes. (HEPATOLOGY 1998;27:1492-1498.)Diet may influence the formation of gallstones (GS) either by modifying gallbladder motility or by altering the biliary lipid composition. The relationships between GS disease and the dietary habits in an Italian free-living population sample are analyzed and discussed in this article. The importance of diet in the pathogenesis of GS has been much debated. Information on this issue can be obtained from experimental, 1-18 clinical, 19-26 and epidemiological studies. [27][28][29][30][31][32][33][34][35] These latter studies have mainly investigated symptomatic GS subjects who were aware of having GS or subjects who had been previously submitted to cholecystectomy. Thus, it could be supposed that they accordingly modified their dietary habits. The present study only included subjects with asymptomatic, previously undiagnosed GS and compar...

show abstract

“…We previously reported on the decrease in the incidence of gallstone formation and hepatic cholesterol mass (2,3) and the increase in fecal bile acid excretion (4) effected by dietary taurine in hypercholesterolemic mice. These results suggested that the protective effect of dietary taurine against cholesterol gallstone formation is related to the stimulation of bile acid synthesis (4).…”

mentioning

confidence: 99%

Effect of dietary taurine on cholesterol 7.ALPHA.-hydroxylase activity in the liver of mice fed a lithogenic diet.

Nakamura-Yamanaka

Tsuji

Ichikawa

1987

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

Self Cite

View full text Add to dashboard Cite

Effect of dietary taurine on cholesterol gallstone formation and tissue cholesterol contents in mice.

Cited by 18 publications

References 8 publications

Effect of taurine administration on serum lipid and biliary lipid composition in man.

Effect of taurine administration on serum lipid and biliary lipid composition in man.

Diet and gallstones in italy: The cross-sectional MICOL results

Effect of dietary taurine on cholesterol 7.ALPHA.-hydroxylase activity in the liver of mice fed a lithogenic diet.

Contact Info

Product

Resources

About