Effect of taurine administration on serum lipid and biliary lipid composition in man.

Tanno, Norihiko; Oikawa, Shinichi; Koizumi, Masaru; Fujii, Yutaka; Hori, Shuichiro; Suzuki, Norihiro; Sakuma, Eriko; Kotake, Hidetoshi; Namai, Kazuyuki; Toyota, Takayoshi

doi:10.1620/tjem.159.91

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…However, Mizushima et al reported that 6 g/day taurine supplementation for 3 weeks induced significant increases in VLDL-C and TG with high fat, high cholesterol, and low polyunsaturated fatty acid / saturated fatty acid (P/S) ratio diets in healthy men [16]. Tanno young men [17]. The present study's results in slightly lean young women are similar to those of previous reports, despite low cholesterol intake and a prolonged administration period.…”

Section: Discussionsupporting

confidence: 89%

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Effects of taurine intake on serum lipids in young women

Matsui

Maruyama

Arai

et al. 2015

FFHD

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Background: Taurine is an abundant amino acid in human cells, promoting ocular and biliary health, which is also used to treat congestive heart failure, hypertension, and hepatitis. Recently, taurine-enriched energy drinks have become popular with young adults, but the effects of taurine on serum lipids in young adults are unknown.Objective: We studied the influence of oral administration of taurine on serum lipid levels in healthy young women.Methods: Ten healthy young women with a mean body mass index of 20.0kg/m2, apolipoprotein E (apoE) phenotype 3/3 and normal menstrual cycles participated. Each subject was instructed to orally ingest 1g of taurine powder after each meal (3g/day) in addition to their usual diets during one menstrual cycle. Before and at the end of taurine intake, physical measurements and blood collection were performed in the morning after a 12-h fast, and 3-day weighted dietary records were obtained. Concentrations of serum lipids, apolipoproteins, and fatty acids in the serum phospholipid fraction were measured.Results: The subjects showed good compliance with taurine intake and none reported adverse effects during the experimental period. After taurine intake, concentrations of total cholesterol, low density lipoprotein cholesterol (LDL-C), free cholesterol, and apolipoprotein B (apoB) increased (p<0.05), while phospholipids tended to increase (p=0.051). Fatty acids in the serum phospholipid fraction also significantly increased (p<0.05). However, triglyceride, remnant-like particle cholesterol, remnant-like particle triglyceride, apoE, the apolipoprotein A-1 (apoA- 1)/apoB ratio and the LDL-C/apoB ratio were unchanged. Furthermore, body weight was significantly increased (p<0.01), but did not correlate with changes either in serum lipids or nutrient intakes.Conclusion: These results suggest that high taurine intake affects lipoprotein metabolism and increases serum lipids in slightly lean young women.Key Words: Taurine, slightly lean young women, serum lipids, remnant lipoprotein, fatty acids of the serum phospholipid fraction.

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Section: Discussionsupporting

confidence: 89%

“…Taurine supplementation was also found to improve insulin sensitivity [14] and hyperlipidemia in obese and overweight men. However, the effects of taurine supplementation on serum lipids have not been defined specifically in humans [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Effects of taurine intake on serum lipids in young women

Matsui

Maruyama

Arai

et al. 2015

FFHD

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“…The well-known involvement of hepatic taurine in bile acid metabolism has led to specific investigations on the role of this sulfur-containing amino acid in steroid metabolism of many animal species (8)(9)(10)(22)(23)(24)(25). In animals that depend on dietary taurine intake, these investigations included the effects of taurine on other lipid classes (1 1, 12, 26).…”

Section: Discussionmentioning

confidence: 99%

Effect of Taurine Levels on Liver Lipid Metabolism: An In Vivo Study in the Rat

Yan¹,

Bravo²,

Cantàfora³

1993

Experimental Biology and Medicine

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Previous studies using guinea pigs and cats have shown that liver lipid composition is affected by intrahepatic taurine levels. The purpose of the present study was to determine whether this sulfonated amino acid could also affect lipid metabolism in the rat, an animal capable of synthesizing substantial amounts of taurine and used extensively in studies on lipid metabolism. Wide variations in the hepatic taurine content were induced by administering either 1% taurine or 1% guanidinoethane sulfonate in the drinking water for 2 weeks. These treatments increased and decreased taurine liver content, respectively, but did not affect either food or water intakes, or growth rates. The plasma concentrations of the major lipid classes in treated animals did not show any significant alteration in comparison to control animals, except for nonesterified fatty acid levels that were significantly lowered by guanidinoethane sulfonate administration. Taurine supplementation did cause a significant decrease in total hepatic lipid content that was attributable to the reduction of free and esterified cholesterol, triglyceride, and phosphatidylethanolamine hepatic concentrations. This same treatment slightly increased both bile flow and secretion of taurine-conjugated primary bile salts. In particular, the proportion of tauro-beta-muricholate significantly increased, whereas that of taurodeoxycholate greatly decreased. The administration of guanidinoethane sulfonate reduced both the bile flow and the secretion of taurine-conjugated bile salts and caused a significant alteration in the ratio between glycine- and taurine-conjugated bile salts. This did not occur after the treatment with taurine. Interestingly, we observed an inverse correlation between hepatic taurine levels and the proportion of either cholesteryl ester in hepatic lipids or taurochenodeoxycholate in biliary bile salts. These facts suggest that taurine hepatic levels influence mostly hepatic steroid metabolism, but they also affect the metabolism of other lipid classes.

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“…The ratio of glycine- to taurine-conjugated bile acids is usually about 4:1 [3]. For an average adult consuming 75 g protein daily that contains 8% glycine, about 30% can be required for conjugated bile acid synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…A similar argument applies for taurine, although peripheral blood level elevations are more affected by variations in sulfur amino acid intake. Substrate limitation of taurine conjugation is indicated by finding that administration of oral taurine at 3.2 g/day for 2 weeks to healthy humans can effectively raise taurine-conjugated bile acids [3]. …”

Section: Introductionmentioning

confidence: 99%

Adult bile acid amino transferase deficiency

Lord

Tuttle²,

Cantor

2014

Am J Case Rep

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Patient: Female, 70Final Diagnosis: Bile acid amino transferase deficiencySymptoms: Headache • indigestion • itching skin • nausea • vomitingMedication: —Clinical Procedure: —Specialty: Gastroenterology and HepatologyObjective:Challenging differential diagnosisBackground:Bile acid synthesis impairments are difficult to diagnose due to non-specific manifestations related to progressive failure to absorb essential fatty acids and fat soluble vitamins and failure to maintain normal intestinal microbiota.Case Report:A 70-year-old female presented with long-standing history of recurrent headaches, indigestion, dry, scaly, itching skin, and fluid around knee joints. Quantitative Electroencephalography (QEEG) revealed widespread excess theta maximum in the temporal regions. A rare pattern of elevated plasma glycine and taurine led to suspicion of BAATD. A stool profile employing molecular probes for commensal bacteria revealed elevation of Fusobacteria spp. Implementation of bile acid replacement therapy (BART) produced rapid remission of headache and other symptoms and a three-month follow up stool profile revealed normalization of fecal Fusobacteria populations that remained normal after one year of BART. QEEG analyses 4 weeks following BART showed evidence of significant improvement in CNS functioning.Conclusions:This case illustrates the potential for diagnosis of latent, adult BAATD by finding a unique pattern of plasma amino acids and monitoring of therapy by observing normalization of fecal commensal bacteria and functional brain assessments.

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Effect of taurine administration on serum lipid and biliary lipid composition in man.

Cited by 14 publications

References 18 publications

Effects of taurine intake on serum lipids in young women

Effects of taurine intake on serum lipids in young women

Effect of Taurine Levels on Liver Lipid Metabolism: An In Vivo Study in the Rat

Adult bile acid amino transferase deficiency

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