Effect of dietary sodium on airways responsiveness and its importance in the epidemiology of asthma: an evaluation in three areas of northern England.

Devereux, G.; Beach, Jeremy; Bromly, C.L.; Avery, A J; Ayatollahi, Seyyed Mohammad Taghi; Williams, SM; Stenton, SC; Bourke, S.; Hendrick, D. J.

doi:10.1136/thx.50.9.941

Cited by 46 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that dietary sodium might affect airway responsiveness (and so might exert a confounding influence on epidemiologic investigations of asthma), but in the present study urinary sodium excretion showed no differences between workers and school leaver control subjects, nor across the exposure subgroups, and it was not related to PD 20 measurements (29). It was not considered further in the investigation.…”

Section: Clinical Surveycontrasting

confidence: 76%

An epidemiologic investigation of asthma in welders.

Beach

Dennis²,

Avery³

et al. 1996

Am J Respir Crit Care Med

Self Cite

View full text Add to dashboard Cite

To clarify whether asthma may be caused by fume from welding mild steel and to evaluate the possible strength of such an effect, we quantified airway responsiveness among young shipyard workers with different levels of fume exposure. Clinical investigation comprised a cross-sectional survey of 19- to 27-yr-old workers who were completing 3 to 9 yr of employment in various trades, and a control group of 15- to 17-yr-old school leavers who were applying for apprenticeships within the same trades. Both groups were subdivided into negligible-, ambient-, or high-exposure subgroups according to expected levels of fume exposure. Actual exposures were assessed in a parallel environmental survey. Participants were investigated by questionnaire, skin prick tests, spirometry, and methacholine tests. Complete data sets were obtained from 1,024 of the 1,070 eligible subjects (96%). Among the workers but not the school leaver controls, there was an increasing prevalence of positive methacholine tests across the exposure subgroups-negligible 37%, ambient 44%, high 49% (p < 0.05). Regression analyses showed that in males after allowing for the effects of atopy, current smoking, and age, the estimated geometric mean level of airway responsiveness of regular welders was twice that of workers with negligible exposure after 5 yr of work. This implies that fume exposure may have been critical in causing asthma in about 1% of the welders. A lesser effect (though not significantly so) was noted among the workers with ambient exposure.

show abstract

Section: Clinical Surveycontrasting

confidence: 76%

An epidemiologic investigation of asthma in welders.

Beach

Dennis²,

Avery³

et al. 1996

Am J Respir Crit Care Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…123 Three other observational studies on relatively large groups of normal men and boys did not reveal a relation between urinary sodium excretion and bronchial reactivity to methacholine. [124][125][126][127] Conclusion: The level of salt intake may be injurious to male patients with asthma. There is no evidence that salt intake effects airway responsiveness in normal subjects.…”

Section: Asthmamentioning

confidence: 99%

Harmful effects of dietary salt in addition to hypertension

2002

View full text Add to dashboard Cite

In addition to raising the blood pressure dietary salt is responsible for several other harmful effects. The most important are a number which, though independent of the arterial pressure, also harm the cardiovascular system. A high salt intake increases the mass of the left ventricle, thickens and stiffens conduit arteries and thickens and narrows resistance arteries, including the coronary and renal arteries. It also increases the number of strokes, the severity of cardiac failure and the tendency for platelets to aggregate. In renal disease, a high salt intake accelerates the rate of renal functional

show abstract

“…A subsequent study examining dietary salt intake and bronchial reactivity in men revealed a positive correlation between airway reactivity and 24-h urine sodium excretion. In contrast to the aforementioned studies, a number of large cohort studies have failed to observe any associations between 24-h urinary sodium excretion and airway reactivity (11,21,59,66). Two large cohort studies by Britton et al (11) and Devereux et al (21) found no association between airway hyperresponsiveness and sodium excretion.…”

mentioning

confidence: 96%

“…In contrast to the aforementioned studies, a number of large cohort studies have failed to observe any associations between 24-h urinary sodium excretion and airway reactivity (11,21,59,66). Two large cohort studies by Britton et al (11) and Devereux et al (21) found no association between airway hyperresponsiveness and sodium excretion. Furthermore, Sparrow et al (59) observed an association between airway reactivity and urinary potassium, but not sodium secretion.…”

mentioning

confidence: 96%

Sodium and asthma: something borrowed, something new?

Hirota

Janssen

2007

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

Some early studies have called attention to the potential contribution of sodium (both dietary and serum levels) in airway-related disease, although the picture was not entirely clear. Two recent developments may now allow a more careful consideration of this: first, the greatly improved understanding of the role of salt in hypertension (particularly the identification of subgroups of salt-sensitive individuals within the general population), and second, the recent discovery of the role of the Na(+)/Ca(2+) exchanger in smooth muscle function. Here, we first review those two developments and then apply them to airway smooth muscle and asthma.

show abstract

Effect of dietary sodium on airways responsiveness and its importance in the epidemiology of asthma: an evaluation in three areas of northern England.

Abstract: Conclusions -If airways responsiveness is related to dietary sodium the relationship is not likely to be strong. (Thorax 1995;50:941-947)

Cited by 46 publications

References 26 publications

An epidemiologic investigation of asthma in welders.

An epidemiologic investigation of asthma in welders.

Harmful effects of dietary salt in addition to hypertension

Sodium and asthma: something borrowed, something new?

Contact Info

Product

Resources

About