Effect of dietary oat β-glucan on high-fat diet induced obesity in HFA mice

Hu, Xinzhong; Sheng, Xialu; Li, Xiaoping; Liu, Liu; Zheng, Jie; Chen, Xingyun

doi:10.1016/j.bcdf.2014.12.006

Cited by 17 publications

(6 citation statements)

References 29 publications

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“…β-Glucan, an indigestible-and hydro soluble-dietary fiber has shown to exhibit much physiological benefits on cholesterol reduction, weight management, cardiovascular risks, diabetes mellitus, metabolic syndrome etc. [7,8]. Being a major soluble fiber found in the cell walls of oats and barley endosperm, the βglucan is commercially extracted from Saccharomyces cerevisiae and also from other sources such as Phellinus linteus or Sparassis crispa [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of mushroom (Schizophyllum spp.) derived β-glucan on low-fiber diet induced gut dysbiosis

Muthuramalingam

Singh

Choi

et al. 2019

JABC

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Dietary pattern has paramount importance in shaping the gut microbiota and its associated host health. Herein this study, long term (12 weeks) impact of mushroom derived dietary fiber, β-glucan, is investigated for its effect on low fiber diet consumption. Inclusion of dietary fiber into the low fiber diet (LFD) increased the abundance of genera Lactobacillus and Anaerostipes, the microbes responsible for butyrate (major 'fuel source' of colonocytes) production. Mice fed LFD with β-glucan showed significant increase in the length of small intestine compared to that of the LFD group without β-glucan. Further, dietary fiber consumption enhanced goblet cell density along with mucosal layer thickness. These results indicate promising effects of β-glucan towards maintenance of healthy gut and gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Effect of mushroom (Schizophyllum spp.) derived β-glucan on low-fiber diet induced gut dysbiosis

Muthuramalingam

Singh

Choi

et al. 2019

JABC

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“…In addition, the reduction in the accumulation of periepididymal adipose tissue by Botryosphaeran may have contributed to the improvement of insulin sensitivity, and better control of the lipid and glycemic profiles in obese animals. Another possible mechanism associated with the hypolipidemic effect of Botryosphaeran can be its action on modulating the gut microbiota to produce short‐chain fat acids (SCFAs) that, in turn, regulate the biosynthesis of lipids in the liver 41,42 . SCFAs are able to regulate lipid levels as these can decrease the accumulation of lipids in adipose tissue, as well as increase the oxidation of lipids in adipose and liver tissues 36 …”

Section: Discussionmentioning

confidence: 99%

“…Xin‐Zhong et al 42 demonstrated that the consumption of a high‐fat diet enriched with three oat products rich in β‐glucans (meal, flour, and bran) by obese Sprague‐Dawley male rats was effective in improving several metabolic parameters. The consumption of oat products led to a reduction in body weights, epididymal fat accumulation, regulated serum lipid levels, and increased levels of SCFAs.…”

Section: Discussionmentioning

confidence: 99%

“…Another possible mechanism associated with the hypolipidemic effect of Botryosphaeran can be its action on modulating the gut microbiota to produce short-chain fat acids (SCFAs) that, in turn, regulate the biosynthesis of lipids in the liver. 41,42 SCFAs are able to regulate lipid levels as these can decrease the accumulation of lipids in adipose tissue, as well as increase the oxidation of lipids in adipose and liver tissues. 36 Miyamoto et al 41 intolerance in high-fat/high-sugar diet-induced obese rats.…”

Section: Discussionmentioning

confidence: 99%

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Extended treatment with (1→3)(1→6)‐β‐d‐glucan (Botryosphaeran) reduces obesity and its comorbidities in high‐fat/high‐sugar diet‐fed rats

Ribeiro

Silva

Giordani

et al. 2022

Cell Biochemistry & Function

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Obesity is associated with other diseases such as diabetes and cancer. Botryosphaeran, a fungal (1→3)(1→6)‐β‐d‐glucan, is described to present antimutagenic, hypoglycemic, hypocholesterolemic, and antitumor activities when administered by gavage over 15 days in rats and mice. Thus, the present study aims to analyze the metabolic effects of Botryosphaeran (12 mg/kg body weight/day) treatment over 30 days in obese Wistar male rats. Obesity was induced in the rats by a high‐fat/high‐sugar diet for 8 weeks. Control rats received a standard diet. On the 5th week, Botryosphaeran treatment commenced. Groups: control, obese, and obese+Botryosphaeran 30 days. In the 8th week, obesity was characterized. Feed intake, glucose and lipid profiles, glucose tolerance, and insulin sensitivity were analyzed. Obese rats showed accumulation of visceral adipose tissue, reduction of muscle mass, glucose intolerance, insulin resistance, hyperglycemia, and dyslipidemia. Botryosphaeran effectively reduced weight gains and the accumulation of retroperitoneal adipose tissue, corrected the levels of glucose, triglycerides, and very low‐density lipoprotein‐cholestrol, and improved insulin sensitivity. Treatment for 30 days was effective in maintaining the beneficial effects demonstrated by this β‐glucan when administered for 15 days without promoting side effects. Treatment with (1→3)(1→6)‐β‐ d‐glucan presented anti‐obesogenic and beneficial metabolic effects in Wistar rats; important for the treatment of obesity and its comorbidities.

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“…A large number of studies have confirmed that β-glucan has important physiological functions. It can promote the proliferation of probiotics, prevent colon cancer [13], reduce blood lipids and cholesterol [14], regulate blood sugar [15,16], improve immunity, anti-aging and moisturizes the skin [17,18].…”

Section: β-Glucanmentioning

confidence: 99%

Preparation of Grain β-glucan Gel and Characteristics of Its Slow-release

Xu¹,

Wu²,

Zhao³

2020

JFNR

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The β-glucan freeze-thaw gel has been used as a carrier to release curcumin. The freeze-dried gel has the ideal sustained release following 5% β-glucan solution by adding 1% β-glucan quality curcumin, repeated freezing and thawing 8 times. The Peppas equation can significantly describe the release mechanism of curcumin in the β-glucan gel. This study further shows that the release of curcumin in the oat β-glucan gel is the Fick diffusion mechanism and coated barley β-glucan is a non-Fick release. Trying to use β-glucan as a completely natural drug delivery carrier opens up new ideas for the use of β-glucan.

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Effect of dietary oat β-glucan on high-fat diet induced obesity in HFA mice

Cited by 17 publications

References 29 publications

Effect of mushroom (Schizophyllum spp.) derived β-glucan on low-fiber diet induced gut dysbiosis

Effect of mushroom (Schizophyllum spp.) derived β-glucan on low-fiber diet induced gut dysbiosis

Extended treatment with (1→3)(1→6)‐β‐d‐glucan (Botryosphaeran) reduces obesity and its comorbidities in high‐fat/high‐sugar diet‐fed rats

Preparation of Grain β-glucan Gel and Characteristics of Its Slow-release

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