Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits.

Ouchi, Yasuyoshi; Tabata, R; Stergiopoulos, K.; Sato, Fumiyasu; Hattori, Akira; Orimo, Hajime

doi:10.1161/01.atv.10.5.732

Cited by 57 publications

(54 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the blood chemical values, TG level was significantly higher in the 6.7% dSSW group, while no significant differences in TC, HDLC, and GLU were found among the 7 water groups. Inverse association between magnesium intake and plasma TG level has been previously reported (Altura et al 1990;Ouchi et al 1990;Sherer et al 1999;Ravn et al 2001;Cohen et al 2002). As shown in Table 1, dDSW and dSSW are rich in calcium and magnesium.…”

Section: Discussionsupporting

confidence: 53%

Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

Tsuchiya

Watanabe

Fujisawa

et al. 2004

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Various processed foods and beverages have been manufactured using deep seawater (DSW), desalted DSW (dDSW), and concentrated DSW in Japan. To confirm the safety of dDSW, we investigated hematologic and blood chemical effects of dDSW in mice. The dDSW and desalted surface seawater (dSSW) were diluted to 6.7%, 10%, and 20% with purified water. BALB/c mice were housed for 12 weeks, and administered the diluted dDSW, dSSW, or purified water as a control during the period. The results for dDSW were compared with those for dSSW and purified water. None of the groups of mice showed any clear abnormal growth or behavior; neither did any show signs of illness nor a single case of death during the 12 weeks study. We found no significant differences between the dDSW and control groups in terms of red blood cell count, hemoglobin, hematocrit, white blood cell count, and neutrophil counts, whereas white blood cell and lymphocyte counts were significantly higher in the 10% dSSW group at the end of 4 and 12 weeks than those in the control group. A significantly higher triglyceride level was detected only in the 6.7% dSSW group. Our results show no evidence of acute or subacute effects of diluted dDSW. Effects of diluted dDSW on hematologic and blood chemical values in mice are thought to be similar to those of purified water. This finding suggests that dDSW is as safe as purified water for drinking water. deep seawater; electrodialytic desalination; hematologic values; blood chemical values; mice

show abstract

Section: Discussionsupporting

confidence: 53%

Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

Tsuchiya

Watanabe

Fujisawa

et al. 2004

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…Simple linear regression demonstrated positive relationship of urinary K to SBP and DBP in JJ-men and of urinary Na/K ratio to DBP in JB-men, but these relationships disappeared when multiple linear regression was applied. Beneficial effects of Mg and K on BP were unclear in this study, despite several investigations showing an antihypertensive effect (9-11, 55,56,62,63) JJ had 1.5-2 times higher urinary taurine (TAU) excretion than JB. Urinary TAU related positively with DBP at the individual level in JJ-women in simple linear regression analysis, but its independent effect on BP was unclear in multiple linear regression analysis controlling for other confounding factors.…”

Section: Discussionmentioning

confidence: 62%

The Relationship of Dietary Factors to Cardiovascular Diseases among Japanese in Okinawa and Japanese Immigrants, Originally from Okinawa, in Brazil.

et al. 1992

View full text Add to dashboard Cite

To investigate the relationship of dietary factors to cardiovascular diseases, we conducted a study of 234 middle-aged Japanese men and women in Okinawa (JJ), and 160 Japanese immigrants of similar age, originally from Okinawa, in Brazil (JB). JB showed double the prevalence (%) of ST-T changes in the electrocardiogram (ECG) (JJ: M3.4, F4.4, JB: M8.3, F10.1) and of hypertension (HT) (JJ: M15.9, F18.4; JB: M32.8, F36.4, p < 0.05) when this was assessed on BP> 160195 and/or the taking of antihypertensive medication; however the mean level of blood pressure did not differ. A gradient in the rate of HT in men and of ECG ST-T changes in both sexes was observed from JJ to JB of first-generation and to JB of second-generation. JB had much higher body mass index (kg/m2) (JJ: M24.8 ± 0.3, F24.8 ± 0.4; JB:M26.2 ± 0.4, F26.5±0.4, p < 0.01) in both sexes, and an 8-fold higher rate of oral contraceptive usage (p < 0.001). Total cholesterol level showed no significant difference between JJ and JB. 24-hour urinary taurine excretion in both sexes and plasma phospholipid n-3 fatty acid level in men were significantly higher in JJ than in JB. The dietary pattern in Japanese immigrants in Brazil, characterized by low fish and large meat intake, is possibly responsible for the higher risk of HT and ECG ST-T changes, indicating the importance of dietary rather than genetic factors. (Hypertens Res 1992;15: 45-55)

show abstract

“…24,25 Increased Mg intake was suggested to counteract these effects in animal models. 26,27 Epidemiological studies have indicated a direct relation between atherosclerosis and low serum Mg, 3,6 -10 which, in turn, depends on dietary intake. A direct relation between serum Mg levels and acute neurological events has not yet been described.…”

Section: Amighi Et Al Magnesium and Neurological Events 25mentioning

confidence: 99%

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Amighi

Sabeti

Schlager

et al. 2004

Stroke

View full text Add to dashboard Cite

Background and Purpose-Magnesium (Mg) deficiency is thought to be a risk factor for cerebrovascular atherosclerosis and complications. We investigated the prognostic impact of Mg serum levels with respect to the occurrence of neurological events in patients with advanced atherosclerosis. Methods-We prospectively studied 323 patients with symptomatic peripheral artery disease and intermittent claudication (197 men; median age, 68 years). Serum Mg was determined, and patients were followed for a median of 20 months (interquartile range, 12 to 25 months) for the occurrence of neurological events, defined as ischemic stroke and/or carotid revascularization (carotid endarterectomy or carotid stenting). Multivariate Cox proportional hazards analysis was applied to assess the association of serum Mg (in tertiles) and neurological events. Results-Neurological events occurred in 35 patients (11%) (15 patients with stroke, 13 with carotid revascularization, and 7 with stroke and subsequent revascularization

show abstract

Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits.

Cited by 57 publications

References 27 publications

Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

Effects of Desalted Deep Sea water on Hematologic and Blood Chemical Values in Mice

The Relationship of Dietary Factors to Cardiovascular Diseases among Japanese in Okinawa and Japanese Immigrants, Originally from Okinawa, in Brazil.

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Contact Info

Product

Resources

About