Effect of Dietary Magnesium Deficiency on the Bones and Teeth of Rats

Bernick, Sol; Hungerford, Gerald F.

doi:10.1177/00220345650440063401

Cited by 29 publications

(8 citation statements)

References 17 publications

(8 reference statements)

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“…10-16) have been reported [91,[95][96][97][98][99][100][101][102]104,[106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][125]. Extrapolating these findings to the domestic cat should be done with caution, however, because the results of these experimental studies are not uniform.…”

Section: Experimental Studies With Vitamin D and Vitamin D Metabolitesmentioning

confidence: 99%

Update on the Etiology of Tooth Resorption in Domestic Cats

Reiter

Lewis

Okuda

2005

Veterinary Clinics of North America: Small Animal Practice

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Feline odontoclastic resorptive lesions (FORL) were first recognized and histologically differentiated from caries in the 1920s [1,2]. Some anecdotal reports describing caries-like lesions at the cervical region of feline teeth followed in the 1950s and 1960s, until two microscopic studies in the 1970s again revealed that FORL were not caries but a type of tooth resorption [3,4]. A recent study showed that cats with FORL have a significantly lower urine specific gravity and significantly higher serum concentration of 25-hydroxyvitamin D (25OHD) compared with cats without FORL [5], indicating that multiple tooth resorption in domestic cats could be the manifestation of some systemic insult rather than a local cause. In this article, the histologic and radiographic appearance of FORL and certain other peculiarities of feline teeth are reviewed. An attempt is then made to compare these findings with changes of the periodontium induced by administration of excess vitamin D or vitamin D metabolites in experimental animals. Histologic and radiographic features of feline odontoclastic resorptive lesionsTooth resorption is caused by odontoclasts. Their precursors derive from hematopoietic stem cells of bone marrow or spleen and migrate from blood vessels of the alveolar bone or periodontal ligament toward the external root

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Section: Experimental Studies With Vitamin D and Vitamin D Metabolitesmentioning

confidence: 99%

Update on the Etiology of Tooth Resorption in Domestic Cats

Reiter

Lewis

Okuda

2005

Veterinary Clinics of North America: Small Animal Practice

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“…On the other hand, copper is an essential trace metal existing in living organisms and is necessary for triggering some of the biological processes. Copper is known as an angiogenic reagent due to its role in the increase of proangiogenic expression and stimulation of the human endothelial cell proliferation . Previous reports have suggested that the incorporation of 5 mol% CuO in BG composition can result in a significant antibacterial efficiency, and an improved bone regeneration capability and a higher angiogenesis stimulation compared to copper‐free BGs.…”

Section: Introductionmentioning

confidence: 99%

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

Moghanian

Ghorbanoghli

Kazem‐Rostami

et al. 2019

Int J of Appl Glass Sci

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In this study, six sol‐gel copper/magnesium substituted derivatives of 58S‐BG, that is, a mol% series of 60SiO2–4P2O5–5CuO–(31–x) CaO/xMgO (where x = 0, 1, 3, 5, 8, and 10), were synthesized as new multifunctional bioactive glasses (BGs). Afterwards, the effect of MgO/CaO substitution on the in vitro formation of nanohydroxyapatite (HA), osteoblast‐like cell responses, and bioactive glasses antibacterial performance were studied. X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) results revealed that Cu‐substituted 58S‐BG consisting of 5 mol% MgO (BG‐5/5) had capability of the formation of HA on its surface while, Cu‐substituted 58S‐BGs consisting 8 mol% and 10 mol% MgO (BG‐5/8 and BG‐5/10) displayed lower bioactivity. The In vitro investigations proved that the highest values of both differentiation and proliferation of MC3T3‐E1 cells can be obtained from a 5 mol% MgO substituted BG. Furthermore, these novel Cu/Mg‐substituted 58S‐BGs displayed antibacterial effect against methicillin‐resistant staphylococcus aureus bacteria. Taken together, the results suggest the equally substituted BG‐5/5 (ie., the one consists of 5 mol% of both CuO and MgO) as a promising candidate for bone tissue engineering, among all newly designed BGs in this work, owing to its desirable cell proliferation, ALP activity, and antibacterial properties.

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“…and have been reported sporadically since that time [3][4][5][6]. With few exceptions, microscopic examinations of magnesium-deficient bone have focused on the epiphyseal growth plate [4,7,8]. The width of the epiphyseal growth plate has been found significantly decreased, and in one instance [3], 35SO4 and 3H-methionine uptake at the plate were reported reduced in long bones of magnesium-depleted rats.…”

Section: Introductionmentioning

confidence: 99%

Influence of magnesium depletion on matrix-induced endochondral bone formation

Schwartz

Reddi

1979

Calcif Tissue Int

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The effect of magnesium deficiency on bone cell differentiation and bone formation was investigated using in vivo matrix-induced endochondral ossification as a test system. Demineralized bone matrix was implanted subcutaneously in young (35-day-old) male Long-Evans rats that had been fed a semisynthetic Mg-deficient diet (50 ppm Mg) for 7 days. Plasma Mg levels were reduced to 25-30% of control values at that time. Control rats were paired the same diet, supplemented to contain 1000 ppm Mg. The implants were harvested 7, 9, 11, 15, and 20 days after implantation and analyzed for Mg and Ca content, 45Ca incorporation, and alkaline phosphatase levels. At each stage, plaques (implants) removed from Mg-deficient rats showed retardation in cartilage and bone differentiation and matrix calcification. Magnesium content was markedly reduced when compared to the control plaques. Histological appearance of the matrix-induced plaques confirmed the retardation in bone development and mineralization suggested by the chemical indicators. Most marked was the virtual absence of bone marrow in 20-day-old plaques in Mg-depleted rats. These data show that bone cell differentiation can occur in a severely Mg-depleted environment, although the onset of mineralization and bone remodeling was delayed and bone marrow differentiation was impaired.

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Effect of Dietary Magnesium Deficiency on the Bones and Teeth of Rats

Cited by 29 publications

References 17 publications

Update on the Etiology of Tooth Resorption in Domestic Cats

Update on the Etiology of Tooth Resorption in Domestic Cats

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

Influence of magnesium depletion on matrix-induced endochondral bone formation

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