Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

García-Legorreta, Arantxa; Soriano-Pérez, Luis Alfonso; Flores-Buendía, Aline Mariana; Medina-Campos, Omar Noel; Noriega, Lilia G.; Granados‐Portillo, Omar; Nambo‐Venegas, Rafael; Tovar, Armando R.; Mendoza-Vargas, Alfredo; Barrera-Oviedo, Diana; Pedraza‐Chaverrí, José; Palacios‐González, Berenice

doi:10.3390/nu12092889

Cited by 27 publications

(20 citation statements)

References 35 publications

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“…Though a content of 0.05% has been extensively used as normal in rat experimental studies, a slightly higher dietary concentration might be required if the experimental conditions might affect the absorption of Mg. A high dietary phosphate content can reduce the absorption and/or availability of Mg, and a decreased magnesium absorption is often found in renal disease 33 . Similarly to our conditions, the contents of 0.1% or around have been also established as the normal levels in many studies addressing dietary Mg supplementation, in which a 0.6% Mg was also given as a high Mg diet 34‐37 . Our results showed that in the uraemic rats fed a normal Mg (0.1%) a systemic inflammatory response was induced, as deduced from the elevation in the plasma of the pro‐inflammatory cytokines TNF‐α, IL‐1β and IL‐6, which are related to acute‐phase responses and inflammation.…”

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 87%

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Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease

López-Baltanás

Rodríguez‐Ortiz

Canalejo

et al. 2021

Eur J Clin Investigation

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Background: Inflammation is a common feature in chronic kidney disease (CKD) that appears specifically associated with cardiovascular derangements in CKD patients.Observational studies have revealed a link between low Mg levels and inflammation. In this study, we hypothesize that Mg might have a modulatory effect on the inflammation induced under the uremic milieu.Methods: In vivo studies were performed in a 5/6 nephrectomized rat model of CKD. Furthermore, a possible direct effect of Mg was addressed through in vitro studies with vascular smooth muscle cells (VSMCs).Results: Uremic rats fed a normal (0.1%) Mg diet showed a systemic inflammatory response evidenced by the elevation in plasma of the pro-inflammatory cytokines TNF-α, IL-1β and IL-6, and GPx activity, a marker of oxidative stress. Importantly, an increased expression of these cytokines in the aortic tissue was also observed. In contrast, a dietary Mg supplementation (0.6%), greatly prevented the oxidative stress and the proinflammatory response. In vitro, in VSMCs cultured in a pro-inflammatory high-phosphate medium, incubation with Mg 1.6 mM inhibited the increase in the production of ROS, the rise in the expression of TNF-α, IL-1β, IL-6 and IL-8 and the activation of NF-κB signaling that was observed in cells incubated with a normal (0.8 mM) Mg. Conclusion:Mg supplementation reduced inflammation associated to CKD; exerting a direct effect on vascular cells. These findings support a possible beneficial effect of Mg supplementation along the clinical management of CKD patients.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 87%

Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease

López-Baltanás

Rodríguez‐Ortiz

Canalejo

et al. 2021

Eur J Clin Investigation

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“…An Mg-deficient diet for 6 weeks altered the gut microbiota and was associated with altered anxiety-like behavior [73]. García-Legorreta et al [76] studied the effect of low and high Mg diets on the modulation of the intestinal microbiota of male Wistar rats. Interestingly, after two weeks, the control and low Mg groups both had higher bacterial diversity than high Mg group.…”

Section: Interaction Between Magnesium and Intestinal Microbiotamentioning

confidence: 99%

“…As the authors concluded for mice with no Mg deficiency, supplementation above recommended Mg intake levels can result in the development of intestinal dysbiosis. Hence, inadequate dietary Mg consumption may increase the capacity to harvest energy from the food [76].…”

Section: Interaction Between Magnesium and Intestinal Microbiotamentioning

confidence: 99%

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Bielik

Kolísek

2021

IJMS

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Adequate amounts of a wide range of micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient to meet these micronutrient requirements. Mineral deficiency does not seem to be the result of a physically active life or of athletic training but is more likely to arise from disturbances in the quality and quantity of ingested food. The lack of some minerals in the body appears to be symbolic of the modern era reflecting either the excessive intake of empty calories or a negative energy balance from drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary micronutrient availability and microbial composition in the gut. However, the influence of human gut microbiota on the bioaccessibility and bioavailability of trace elements in human food has rarely been studied. Bacteria play a role by effecting mineral bioavailability and bioaccessibility, which are further increased through the fermentation of cereals and the soaking and germination of crops. Moreover, probiotics have a positive effect on iron, calcium, selenium, and zinc in relation to gut microbiome composition and metabolism. The current literature reveals the beneficial effects of bacteria on mineral bioaccessibility and bioavailability in supporting both the human gut microbiome and overall health. This review focuses on interactions between the gut microbiota and several minerals in sport nutrition, as related to a physically active lifestyle.

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“…Minerals are associated with bacterial physiological processes reshaping the gut microbiota’s structure and composition 49 . Fermented dairy products like yogurt are rich in many minerals with a higher bioavailability.…”

Section: Discussionmentioning

confidence: 99%

Insights into the nutritional properties and microbiome diversity in sweet and sour yogurt manufactured in Bangladesh

Islam

Tanzina

Foysal

et al. 2021

Preprint

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Yogurt quality mainly depends on nutritional properties, microbial diversity and purity of starter culture. This study aimed to assess the nutritional composition and microbiome diversity in yogurt. Microbial diversity was analyzed by 16S and 18S rRNA based high-throughput sequencing. Significantly (P<0.05) higher pH, fat, moisture, total solid and solid-non-fat contents (%) were observed in sweet yogurt whereas sour varieties had significantly higher ash and minerals. Metagenomic investigation showed that 44.86% and 55.14% reads were assigned to bacterial and fungal taxa, respectively, with significantly higher taxonomic richness in sour yogurt. A significant difference in bacterial (Ppermanova=0.001) and fungal (Ppermanova=0.013) diversity between sweet and sour yogurt was recorded. We detected 76 bacterial and 70 fungal genera across these samples which were mostly represented by Firmicutes (>92%) and Ascomycota (98%) phyla, respectively. Among the detected genera, 36.84% bacterial and 22.86% fungal genera were found in both yogurt types. Our results suggest that Streptococcus (50.82%), Lactobacillus (39.92%), Enterobacter (4.85%), Lactococcus (2.84%) and Aeromonas (0.65%) are the most abundant bacterial genera, while Kluyveromyces (65.75%), Trichosporon (8.21%), Clavispora (7.19%), Candida (6.71%), Iodophanus (2.22%), Apiotrichum (1.94%), and Issatchenkia (1.35%) are the most abundant fungal genera in yogurt metagenomes. This is the first study on nutritional properties and microbiome diversity of Bangladeshi yogurt that would be a benchmark for safe production of quality yogurt by commercial manufacturers.

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Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

Cited by 27 publications

References 35 publications

Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease

Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Insights into the nutritional properties and microbiome diversity in sweet and sour yogurt manufactured in Bangladesh

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