Effect of dietary linoleate/α-linolenate balance on experimentally induced gastric injury in rats

Effects of α-linolenic acid on colonic secretion in rats with experimental colitis

“…11 Previous studies have reported that ingested α-linolenic acid is metabolized to other n-3 PUFAs, such as EPA and DHA, through a process of elongation and desaturation in liver and adipose tissues, and also that α-linolenic acid exerts anti-infl ammatory effects by increasing the tissue level of EPA and by decreasing the level of arachidonic acid, thereby modulating eicosanoid production. 28,29 Our results showed that the administration of α-linolenic acid increased colonic mucosal α-linolenic acid and EPA levels and decreased the level of arachidonic acid. The suppression of bradykinin-stimulated ∆Isc by the addition of AA861 was signifi cantly higher in the perilla group than in the soybean group in the experimental colitis rats, although there was no signifi cant difference in baseline Isc after pretreatment with AA861 between the two groups.…”

Lipid Nutrition Guidelines

“…1 The ranges of dietary LA n-6/ALA n-3 ratios and tissue ARA/EPA ratios need to be carefully estimated in different tissues where prostaglandin E2 (PGE2) plays important roles as a pathological mediator or protective mediator. In a water-immersion, stress-induced ulcer model, the dietary n-6/n-3 ratio can be lowered by roughly 1/1 or even lower [42], a level which is difficult to achieve by increasing intake of n-3 fatty acids under normal dietary conditions, as average intake of LA n-6 is ≥15 g/day in Japan (Figure 3, p. 10).…”

“…Rats were fed diets with different n-6/n-3 ratios by varying perilla oil and safflower oil as well as their mixtures. Water-immersion stress was loaded for 6 h and then the ulcer lesion was examined 24 h later [42]. Each column and bar represent the mean and SEM of 6 to 8 rats in each group.…”

Lipídio: fator de risco e prevenção do câncer de mama

“…Matsuba et al 27 examinaram os efeitos de três óleos sobre a tumorgênese animal, pois se diferenciavam nas concentrações de ácido linoléico e ácido linolênico (taxas de ω-6: ω-3). Comparado com o óleo de girassol (70,0% ácido linoléico e 0,1% ácido linolênico) e com o óleo de soja (50,0% ácido linoléico e 5,0% ácido linolênico), o óleo de perila (15,0% ácido linoléico e 65,0% ácido linolênico), usado principalmente no Japão, preveniu tumores de mama em ratos.…”