Effect of Dietary Keto Acids on Intermediary Metabolism of Nutrients in Atlantic Salmon (<i>Salmo salar</i>) during 17-β-Estradiol-Induced Vitellogenin Synthesis

Olin, Thomas; Bergström, Eva; Jungvid, Hans; Decken, Alexandra von der

doi:10.1080/09064709209410136

Cited by 4 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prandini et al (2012) also found that, when added at rates of either 3 or 6 g kg −1 of feed, AKG decreased endogenous N-losses. In Atlantic salmon, dietary supplementation with 5% AKG diminishes N-excretions (Olin et al, 1992). Our data demonstrated that the dietary AKG supplementation reduced N-excretion in the urine, while also decreasing the content of total N and the rate of its emission.…”

Section: Discussionsupporting

confidence: 49%

“…This was also demonstrated by Prandini et al (2012), who tested rats given AKG supplements of either 3 or 6 g kg −1 feed. In Atlantic salmon (Salmo salar), dietary supplementation with 5% AKG reduced N-excretions without a negative effect on vitellogenin synthesis (Olin et al, 1992). Investigations by Blomqvist and Hammarqvist (1995) revealed that this molecule can prevent uncontrolled N-losses from muscle protein in human patients suffering from postsurgical trauma, burns, or chronic malnutrition, while Riedel et al (1996) showed that AKG controls AA blood profiles and reduces the level of blood urea in patients undergoing hemodialysis.…”

Section: Q3mentioning

confidence: 99%

See 1 more Smart Citation

Growth performance, nitrogen balance, and metabolism of calcium and phosphorus in growing pigs fed diets supplemented with alpha-ketoglutarate

Chen

Yang

et al. 2017

Animal Feed Science and Technology

View full text Add to dashboard Cite

We investigated the effects of dietary alpha-ketoglutarate (AKG) supplementation on growth performance, the nitrogen (N) balance, and metabolism of calcium (Ca) and phosphorus (P) in growing pigs. Sixteen healthy animals (Large × White × Landrace) of similar initial weight (40.08 ± 0.78 kg) were randomly assigned to two dietary groups. The pigs were fed a basic diet containing either 0 (control) or 10 g AKG kg −1 for 28 d. Their faeces and urine were collected continuously from Days 23-25. On Day 28, all of them were killed and their right rear femurs and tibias were removed. Pigs fed diets with AKG tended to have higher average daily gain (ADG; P = 0.088), but their urinary-N levels and excretion of total N were 24.50% (P = 0.012) and 23.67% (P = 0.011) lower, respectively, when compared with corresponding values measured from the control group. However, their apparent N-digestibility and net protein utilization were increased by 2.43% (P = 0.044) and 11.84% (P = 0.002), respectively, over the control. Furthermore, supplemental AKG decreased faecal-and urinary-Ca levels by 29.56% (P = 0.045) and 24.54% (P = 0.001), respectively, while enhancing P-retention, apparent Ca-digestibility, and apparent P-digestibility by 27.10% (P = 0.002), 14.51% (P = 0.041), and 16.62% (P = 0.010), respectively. The addition of AKG also elevated the concentrations of ash, P, and Ca (P = 0.012, P = 0.002, and P = 0.004, respectively) in the femur samples, and increased bone density (P = 0.003), but did not affect those parameters in the tibias. These results indicate that dietary supplementation with AKG can improve the utilization of N, Ca, and P; while effectively reducing N, Ca, and P emissions; and promoting N-, Ca-, and P-metabolism in growing pigs.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Q3mentioning

confidence: 99%

Growth performance, nitrogen balance, and metabolism of calcium and phosphorus in growing pigs fed diets supplemented with alpha-ketoglutarate

Chen

Yang

et al. 2017

Animal Feed Science and Technology

View full text Add to dashboard Cite

show abstract

“…Similarly, supplementation with 1.5% AKG promoted expression of the GS gene in the hindgut and increased GS activity in the intestines of common carp (Dong, Wei, Yu, Wang & Xu ). In Atlantic salmon a 5% AKG supplement reduces nitrogen excretion without any negative effects on growth or vitellogenin synthesis (Olin, Bergstrom, Jungvid & Vonderdecken ). In rats, the levels of circulatory urea and non‐protein nitrogen decreased significantly when rats were treated with AKG (Velvizhi et al .…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary α‐ketoglutarate supplementation on the antioxidant defense system and HSP 70 and HSP 90 gene expression of hybrid sturgeon A cipenser schrenckii ♀ × A . baerii ♂ exposed to ammonia‐N stress

Wang

et al. 2016

Aquac Res

View full text Add to dashboard Cite

This study was conducted to determine the effects of dietary a-ketoglutarate (AKG) supplementation on the antioxidant defense system and gene expression of heat shock protein (HSP) 70 and HSP 90 in hybrid sturgeons Acipenser schrenckii ♀ 9 A. baerii ♂ exposed to ammonia-N stress. A 2 9 3 factorial experiment was arranged, in which each diet (0%, 1% AKG) was randomly assigned to 0.25 (control) 5 and 10 mg L À1 ammonia-N groups with three replicate aquaria for each 72 h. The 10 mg L À1 ammonia-N significantly increased serum ammonia concentrations and intestinal Gln concentrations and GS activity compared with the 0.25 or 5 mg L À1 ammonia-N groups. The intestinal Gln concentration and GS activity increased, and the serum ammonia concentration decreased, in fish given dietary supplementation of 1.0% AKG compared with fish given diets without AKG. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in serum, gills and intestines decreased when fish were exposed to 5 or 10 mg L À1 ammonia-N, and their activity increased in fish given diets with 1% AKG. Catalase in the serum and gills decreased when fish were exposed to 5 or 10 mg L À1 ammonia-N and increased in fish given diets with 1% AKG. The 10 mg L À1 ammonia-N or 1% AKG supplementation increased HSP 70 and HSP 90 gene expression in the liver. The increased activity of antioxidant enzymes, and increased HSP 70 and HSP 90 gene expression in fish fed diets containing 1% AKG suggested higher tolerance to ammonia-N stress.

show abstract

“…Dietary AKG supplementation improved the growth performance and glutamine synthesis of the juvenile hybrid sturgeon ( Acipenser schrenckii ♀ × Acipenser baerii ♂ ) (Wang et al., ) in our laboratory. In Atlantic salmon ( Salmo salar ), a 50 g kg −1 AKG supplement reduced the nitrogen excretion without any negative effects on growth or vitellogenin synthesis (Olin, Bergstrom, Jungvid, & Vonderdecken, ). AKG is a metabolite in the tricarboxylic acid cycle of both animals and plants.…”

Section: Introductionmentioning

confidence: 99%

Effects of α-ketoglutarate on the growth performance, amino acid metabolism and related gene expression of mirror carp (Cyprinus carpio)

et al. 2016

View full text Add to dashboard Cite

A 70-day feeding experiment was conducted to assess the effects of α-ketoglutarate (AKG) supplementation in different protein sources of diets on the growth performance, nitrogen metabolism and related gene expression of mirror carp. Two kinds of protein diets (soybean meal protein source and fish meal and soybean meal compound protein source) and two levels of AKG (0 g kg −1 and 15 g kg −1 , respectively) were utilized. Each experimental diet was fed three times a day with five replicates of 20 fish per tank with an average individual weight of 217.93 ± 0.78 g.The results indicated that AKG significantly improved the protein efficiency ratio and decreased the feed conversion rate (FCR) (p < .05). Soybean protein significantly decreased the weight gain rate and increased the FCR (p < .05). In addition, diets with AKG significantly improved the concentration of glutamine and glutamic acid (Glu) in the foregut and hindgut (p < .05), as well as the glutamine synthetase (GS) activity in the foregut (p < .05). Soybean protein significantly decreased the concentration of Glu and GS activity in the hindgut (p < .05). AKG significantly improved the contents of threonine, alanine, proline and essential amino acid in muscle (p < .05). Dietary supplementation with AKG significantly improved GS gene expression in the intestine and reduced Rhesus glycoprotein (Rhag and Rhbg) gene expression in the gill (p < .05). From the results, we know that a diet with AKG is beneficial for the growth and amino acid metabolism of carp. K E Y W O R D Samino acid, gene expression, glutamine, glutamine synthetase, mirror carp, α-ketoglutarate

show abstract

Effect of Dietary Keto Acids on Intermediary Metabolism of Nutrients in Atlantic Salmon (Salmo salar) during 17-β-Estradiol-Induced Vitellogenin Synthesis

Cited by 4 publications

References 25 publications

Growth performance, nitrogen balance, and metabolism of calcium and phosphorus in growing pigs fed diets supplemented with alpha-ketoglutarate

Growth performance, nitrogen balance, and metabolism of calcium and phosphorus in growing pigs fed diets supplemented with alpha-ketoglutarate

Effects of dietary α‐ketoglutarate supplementation on the antioxidant defense system and HSP 70 and HSP 90 gene expression of hybrid sturgeon A cipenser schrenckii ♀ × A . baerii ♂ exposed to ammonia‐N stress

Effects of α-ketoglutarate on the growth performance, amino acid metabolism and related gene expression of mirror carp (Cyprinus carpio)

Contact Info

Product

Resources

About