Effect of Dietary Green Tea Catechin Preparation on Oxidative Stress Parameters in Large Intestinal Mucosa of Rats

Yamamoto, Masahide; Miyamoto, Sayuri; Moon, Jae‐Hak; Murota, Kazuo; Hara, Yukihiko; Terao, Junji

doi:10.1271/bbb.70.286

Cited by 16 publications

(11 citation statements)

References 12 publications

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“…Green tea extract when simultaneously administered -els in the serum (120%) and liver (53%). The potent antioxidant activity of green tea extract was consistent with many reports published in recent literature (Yamamoto et al, 2006). Green tea suppresses ROS formation through its polyphenolic contents such as catechins imparting a strong antioxidant activity.…”

Section: Tbarssupporting

confidence: 90%

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Green tea modulates reserpine toxicity in animal models

et al. 2009

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-Reserpine, a natural product extracted from or -ria, is a known dopamine depleter that inhibits several neurotransmitters. Reserpine has been used clinically to control hypertension, schizophrenia, insomnia and insanity. The use of this drug, however, has been limited because of its side effects which include oxidative damage to organs, including the liver. Green tea catechins are potent antioxidants that have the potential to counteract reserpine induced oxidative stress. This study investigated the merits of administering green tea concurrently with reserpine to prevent oxidative hepatic damage in Sprague-Dawely (SD) rats. Reserpine was found to cause hepatic damage, with elevated levels of oxidative stress markers, such as Thiobarbituric Acid Reactive Substances (TBARS), transaminases and cholesterol. Reserpine also induced hepatic ultra-structural damage in the cytoplasmic membrane, nuclear envelope, endoplasmic reticulum (rER), ribosomal stripping and mitochondria. Electron microscopy examination showed revival of liver cells as a result of green tea extract administration to experimental rats.

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Section: Tbarssupporting

confidence: 90%

“…Several studies with green tea have demonstrated a causal relationship between green tea exposure and recovery of liver damage caused by oxidants other than reserpine (De Oliveira et al, 2006;Singal et al, 2006;Yamamoto et al, 2006). Results obtained in the present potent antioxidant against oxidative damage caused by reserpine.…”

Section: Discussionmentioning

confidence: 59%

Green tea modulates reserpine toxicity in animal models

et al. 2009

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“…ferent inducers in different organs (Hong et al, 2001;Das et al, 2002;Hiroyasu et al, 2002;Skrzydlewska et al, 2002;Zhang et al, 2002;Chen et al et al, 2004;Augustyniak et al, 2005;El-Beshbishy, 2005;Erba et al, 2005;Mohamadin et al, 2005;Sadzuka et al, 2005;Skrzydlewska et al, 2005;Yamamoto et al, 2006). Green tea suppresses reactive oxygen species (ROS) formation through polyhydroxy phenolics such as catechins that impart strong antioxidant activity.…”

Section: Figmentioning

confidence: 99%

Inhibition property of green tea extract in relation to reserpine-induced ribosomal strips of rough endoplasmic reticulum (rER) of the rat kidney proximal tubule cells

et al. 2009

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-The aim of this study was to evaluate the effect of green tea in inhibiting and reversing the nephrotoxicity of reserpine -a potent oxidative stress inducer -which induced cellular kidney damage. Serum biochemical parameters, antioxidant enzyme levels, thiobarbituric acid reactive substances (TBARS) and serum transaminases (glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT)) values and histopathology were systematically evaluated. Reserpine exposure led -ters and ultrastructural evaluation. Sprague-Dawely (S.D.) rats were intraperitonealy administered reserpine to induce oxidative kidney damage. Experimental rats were given green tea extract according to the protocol given below. Sixty rats were randomly divided into six groups, with 10 rats in each group. Reserpine was found to cause kidney proximal tubule damage, such as stripping and clustering of ribosomes from the rough endoplasmic reticulum (rER) and demolishing of mitochondrial christae with elevated level of oxidative stress markers, such as TBARS. While the ultrastructural study showed a revival of kidney proximal tubule cells as a result of the administration of green tea extract to rats. We suggest that green tea might elevate antioxidant defense system, clean up free radicals, lessen oxidative damages and protect kidney against reserpine -induced toxicity and thus had a potential protective effect.

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“…(Figure 23. 2) Iron chelation may also help to alleviate its pro-oxidant effects in the large intestine (Yamamoto et al, 2006); one must keep in mind that about 90% of iron is not absorbed, and therefore is present in colon lumen. …”

Section: Section 4 Compositional and Nutritional Aspectsmentioning

confidence: 99%

Tea and Iron Metabolism

Bouglé

2013

Tea in Health and Disease Prevention

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Effect of Dietary Green Tea Catechin Preparation on Oxidative Stress Parameters in Large Intestinal Mucosa of Rats

Cited by 16 publications

References 12 publications

Green tea modulates reserpine toxicity in animal models

Green tea modulates reserpine toxicity in animal models

Inhibition property of green tea extract in relation to reserpine-induced ribosomal strips of rough endoplasmic reticulum (rER) of the rat kidney proximal tubule cells

Tea and Iron Metabolism

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