Effect of Dietary Fructose on Free Fatty Acid Release from Adipose Tissue and Serum Free Fatty Acid Concentration in the Rat

Abstract

The administration of a diet, containing 70 cal% of fructose, increases in rats, as compared with a diet containing 70 cal% of glucose, the release of free fatty acids (FFA) from adipose tissue in vitro. Since the glycerol release from adipose tissue is not increased by the high fructose diet, it may be concluded that the enhanced FFA release in the fructose group is due to a reduced re-esterification of FFA in adipose tissue rather than to an enhanced hpolysis. The serum concentrations of FFA are increased by fructose intake temporarily (for the first week of the diet administration), the increased FFA release from adipose tissue being present up to 1 month after starting the diet. The reduced re-esterification of FFA in fructose-fed rats is probably connected with the reduced glucose utilization in adipose tissue. None of the described effects of the fructose diet seems to result from insulin deficiency since no difference was found in the serum insulin concentrations between the groups on the fructose and glucose diet. It is speculated whether the enhanced FFA release from adipose tissue in rats fed the fructose diet may participate in the mechanism of fructose-induced hypertriglyceridaemia.

Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs

“…FFAs during fasting or in the absence of glucose are released from adipose tissue and are primarily metabolized by skeletal muscle and the liver (58). It is well established that chronic increased levels of circulating FFAs can increase the risk of obesity, hepatic lipid deposition, insulin resistance, type 2 diabetes and cardiovascular disease (59) and increased fatty acid synthesis has been shown to occur following fructose consumption (60)(61)(62). The effects of fructose on fatty acid synthesis is likely to be dose-dependent, due to the lipogenic effects of fructose.…”

Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat/Medium-Fructose Diet

“…Liver steatosis is not only caused by de novo lipogenesis but also by the intake of free fatty acids. A previous study reported that a high-fructose diet enhances the release of fatty acids from adipocytes [22]. In addition, lipid oxidation is involved in the output (i.e., lipids released from the liver) [21].…”