Effect of dietary constituents on the gastrointestinal absorption of 203Pb in man

Blake, K.C.H.; Barbezat, G. O.; Mann, Michael D.

doi:10.1016/0013-9351(83)90178-0

Cited by 47 publications

(28 citation statements)

References 13 publications

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“…Various investigators (9)(10)(11) have demonstrated absorption in the range of 30 to 70% when solubilized Pb was administered to fasted subjects. These same investigators (9-11) demonstrated significantly reduced absorption (range 3.5-9%) when solubilized Pb was administered with a meal.…”

Section: Discussionmentioning

confidence: 99%

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Bioavailability of soilborne lead in adults, by stable isotope dilution.

Maddaloni

Lolacono

Manton

et al. 1998

Environ Health Perspect

130

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Using stable isotope dilution, we determined the bioavailability of soilborne lead (Pb) in human adult volunteers. Soil from a residential yard at a mining-impacted federal Superfund site that had negligible amounts of other priority pollutants was dried and screened through a 25-pm mesh sieve. The <250-pm fraction, which likely represents that ingested via hand-to-mouth activity, was then sterilized by exposure to radiation. Ten replicate samples yielded a mean (SD) soil Pb concentration of 2924±36 ppm, and a mean 206Pb/207Pb ratio of 1.1083±0.0002, indicating remarkable soil homogeneity. Six adults with 206Pb/207Pb ratios of > 1.190 were admitted to the clinical research center and fasted overnight prior to dosing with 250 pg Pb/70 kg bw (i.e., 85.5 mg soilf70 kg) in a gelatin capsule. Blood for Pb and 206Pb/207Pb ratios was obtained at 14 time points through 30 hr. Results of the isotopic analyses from these subjects indicate that on average 26.2% ±8.1 of the administered dose was absorbed. Six additional subjects were subsequently studied but ingested soil immediately after a standardized breakfast. Bioavailability in this group was only 2.52% ± 1.7. Collectively, this study provides the first experimental estimates of soil Pb absorption in humans, and should allow for more precise estimates of health risks due to Pb-contaminated soil.

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Section: Discussionmentioning

confidence: 99%

“…Past human dietary studies employing solubilized Pb in an aqueous vehicle (9)(10)(11) may provide some insight regarding the extent of Pb absorption from soil. However, the Pb/soil matrix is believed to influence absorption through factors such as Pb speciation, particle size distribution, and organic/mineral content of the soil (12).…”

mentioning

confidence: 99%

Bioavailability of soilborne lead in adults, by stable isotope dilution.

Maddaloni

Lolacono

Manton

et al. 1998

Environ Health Perspect

130

View full text Add to dashboard Cite

show abstract

“…These studies typically have assessed the absorption of Pb in rodent models at doses delivered in the diet that were substantially higher than those plausible for most environmental exposures. Excessive doses of soil containing high concentrations of other cations and minerals, in addition to minerals present in the diet, presumably could depress the absorption fraction of lead in rats as it does in humans (Blake et al, 1983). Evaluation of lead bioavailability studies in rats by means of a physiologically based kinetic model revealed a reduction in the fractional absorption of lead as oral intake increased with the magnitude of this dose effect being leadsource dependent (Polak et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of Lead to Juvenile Swine Dosed with Soil from the Smuggler Mountain NPL Site of Aspen, Colorado

et al. 1997

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“…In human studies, dietary components, calcium, phosphorus, phytate (inositol hexaphosphate), and fiber reduced lead absorption (21)(22)(23). Combinations of calcium and phosphorus reduced lead absorption more than the presence of increased levels of calcium or phosphorus alone (22,24).…”

Section: The Gravity Of Leadmentioning

confidence: 99%