Bioavailability of Lead to Juvenile Swine Dosed with Soil from the Smuggler Mountain NPL Site of Aspen, Colorado

Casteel, Stan W.; Cowart, R. P.; Weis, Christopher; Henningsen, Gerry M.; Hoffman, Eva J.; Brattin, William J.; Guzman, Roberto E.; STAROST, MATTHEW F.; Payne, John T.; Stockham, Steven L.; BECKER, STEPHEN V.; Drexler, John W.; Turk, James R.

doi:10.1093/toxsci/36.2.177

Cited by 30 publications

(34 citation statements)

References 20 publications

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“…The same pattern (nonlinearity for blood lead concentration and linearity for tissues) was observed in swine administered lead acetate intravenously (Casteel et al 1997). These results suggest that the nonlinearity in the lead dose-blood lead concentration relationship may derive from an effect of lead dose on some aspect of the biokinetics of lead other than absorption.…”

Section: Effect Of Dosesupporting

confidence: 56%

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

Herring

Eagles‐Smith

Buck

2017

Journal of Raptor Research

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Section: Effect Of Dosesupporting

confidence: 56%

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

Herring

Eagles‐Smith

Buck

2017

Journal of Raptor Research

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“…We worked with the swine model that EPA previously used to estimate site-specific oral soil lead bioavailability (31). The Supporting Information provides details.…”

Section: Results From Iinertmentioning

confidence: 99%

Peer Reviewed: Reducing Children's Risk from Lead in Soil

Ryan¹,

Scheckel²,

Berti³

et al. 2004

Environ. Sci. Technol.

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179

139

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“…In the past, investigators have employed animal models to study the bioavailability of Pb in soil (7,8). These studies, however, have primarily focused on predicting bioavailability in children rather than in adults.…”

mentioning

confidence: 99%

Bioavailability of soilborne lead in adults, by stable isotope dilution.

Maddaloni

Lolacono

Manton

et al. 1998

Environ Health Perspect

130

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Using stable isotope dilution, we determined the bioavailability of soilborne lead (Pb) in human adult volunteers. Soil from a residential yard at a mining-impacted federal Superfund site that had negligible amounts of other priority pollutants was dried and screened through a 25-pm mesh sieve. The <250-pm fraction, which likely represents that ingested via hand-to-mouth activity, was then sterilized by exposure to radiation. Ten replicate samples yielded a mean (SD) soil Pb concentration of 2924±36 ppm, and a mean 206Pb/207Pb ratio of 1.1083±0.0002, indicating remarkable soil homogeneity. Six adults with 206Pb/207Pb ratios of > 1.190 were admitted to the clinical research center and fasted overnight prior to dosing with 250 pg Pb/70 kg bw (i.e., 85.5 mg soilf70 kg) in a gelatin capsule. Blood for Pb and 206Pb/207Pb ratios was obtained at 14 time points through 30 hr. Results of the isotopic analyses from these subjects indicate that on average 26.2% ±8.1 of the administered dose was absorbed. Six additional subjects were subsequently studied but ingested soil immediately after a standardized breakfast. Bioavailability in this group was only 2.52% ± 1.7. Collectively, this study provides the first experimental estimates of soil Pb absorption in humans, and should allow for more precise estimates of health risks due to Pb-contaminated soil.

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Bioavailability of Lead to Juvenile Swine Dosed with Soil from the Smuggler Mountain NPL Site of Aspen, Colorado

Cited by 30 publications

References 20 publications

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

Peer Reviewed: Reducing Children's Risk from Lead in Soil

Bioavailability of soilborne lead in adults, by stable isotope dilution.

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