Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle

Chan, W.K.M.; Decker, Eric A.; Chow, Ching K.; Boissonneault, Gilbert A.

doi:10.1007/bf02578242

Cited by 75 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This state may account for the synergistic effect of the combined use of CAT and Vit E. This combination was detected to be more effective in decreasing the lipid peroxides in liver and heart tissues of rats than dietary CAR or Vit E alone. 30,31,35 In the current study, no amelioration was observed in the disturbed serum and tissue Figure 1. The effect of CAR þ Vit E treatments on DOX-induced histopathological alterations in the heart, liver, and kidney tissues (H&E).…”

Section: Discussionmentioning

confidence: 49%

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

et al. 2015

View full text Add to dashboard Cite

Objective: Oxidative stress plays an important role in doxorubicin (DOX)-induced toxicity. Carnosine (CAR) is a dipeptide with antioxidant properties. The aim of this study was to evaluate the decreasing or preventive effect of CAR alone or combination with vitamin E (CAR + Vit E) on DOX-induced toxicity in heart, liver, and brain of rats. Methods: Rats were treated with CAR (250 mg kg−1 day−1; intraperitoneally (i.p.)) or CAR + Vit E (equals 200 mg kg−1 α-tocopherol; once every 3 days; intramuscularly) for 12 consecutive days. On the 8th day of treatment, rats were injected with a single dose of DOX (30 mg kg−1, i.p.). Serum cardiac troponin I (cTnI), urea, and creatinine levels; alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities; and oxidative stress parameters in tissues were measured. We also determined thiobarbituric acid reactive substances, diene conjugate, protein carbonyl (PC), and glutathione levels and antioxidant enzyme activities. Results: DOX resulted in increased serum cTnI, ALT, AST, urea, and creatinine levels and increased lipid peroxide and PC levels in tissues. CAR or CAR + Vit E treatments led to decreases in serum cTnI levels and ALT and AST activities. These treatments reduced prooxidant status and ameloriated histopathologic findings in the examined tissues. Conclusion: Our results may indicate that CAR alone, especially in combination with Vit E, protect against DOX-induced toxicity in heart, liver, and kidney tissues of rats. This was evidenced by improved cardiac, hepatic, and renal markers and restoration of the prooxidant state and amelioration of histopathologic changes.

show abstract

Section: Discussionmentioning

confidence: 49%

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

et al. 2015

View full text Add to dashboard Cite

show abstract

“…(2005) showed that hydrolysis of the dipeptide by carnosinase in plasma might mean that carnosine may not be taken up by skeletal muscles. Chan et al. (1994b) reported that feeding a diet containing supplemental carnosine (875 mg/kg diet) decreased the formation of thiobarbituric acid‐reactive substances in rat skeletal muscle, but did not increase the carnosine level in muscle.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

Jiang

Lin

et al. 2010

Journal of Animal Physiology and Animal Nutrition

View full text Add to dashboard Cite

This study was conducted to determine the effect of dietary carnosine (β-alanyl-L-histidine) supplementation on antioxidant capacity and meat quality of pigs. 72 pigs approximately 60 kg were fed a corn- and soybean meal-based diet supplemented with 0, 25, 50 or 100 mg carnosine per kg diet for 8 weeks. Carnosine supplementation did not affect growth performance and carcass traits of pigs. However, the addition of 100 mg carnosine per kg diet increased pH value of muscle at 45 min, 24 h and 48 h postmortem. It also decreased drip loss at 48 h postmortem and increased redness value of muscle at 45 min postmortem (p < 0.05). The addition of 100 mg carnosine per kg diet enhanced glycogen concentration and Ca-ATPase activity at 24 and 48 h postmortem, and reduced malondialdehyde and carbonyl protein complexes concentrations in muscle at 24 h postmortem (p < 0.05). The addition of 100 mg carnosine per kg diet increased glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities in plasma, liver or muscle, as well as SOD and GSH-Px genes expression in muscle (p < 0.05). Taken together, these findings indicate that carnosine supplementation improves antioxidant capacity and meat quality of pigs.

show abstract

“…Carnosine is found in the brain, heart, skin, liver, kidney, and skeletal muscle of various animals [Chan et al (1994); Crush (1970)]. Skeletal muscle in particular contains a high quantity of carnosine.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Sprint Training on Skeletal Muscle Carnosine in Humans

Suzuki

Ito

Takahashi

et al. 2004

Int. J. Sport Health Sci.

View full text Add to dashboard Cite

It has been suggested that histidine-containing dipeptide carnosine (ß It has been suggested that histidine-containing dipeptide carnosine (ß It has been suggested that histidine-containing dipeptide carnosine ( -alanyl-L-histidine), which is believed to act as a cytosolic buffering agent, is present predominantly in skeletal muscle. The purpose of this study was to investigate the effects of sprint training (30-s maximal cycle ergometer sprinting) on muscle carnosine concentration. Six untrained males trained 2 days per week for 8 weeks on an electronic-braked cycle ergometer. Muscle biopsy samples were taken from the vastus lateralis before and two days after the last training session and were analyzed for carnosine concentration by the use of an amino acid autoanalyzer. The carnosine concentration was signifi cantly increased after sprint training (P concentration was signifi cantly increased after sprint training (P concentration was signifi cantly increased after sprint training ( < 0.05). The mean power P < 0.05). The mean power P during 30-s maximal cycle ergometer sprinting was signifi cantly increased following training. When dividing the 30-s sprinting into 6 phases (0-5, 6-10, 11-15, 16-20, 21-25, 26-30 s), the magnitude of increase in mean power was signifi cantly larger for the last 2 phases than the fi rst phase (P fi rst phase (P fi rst phase ( < 0.05). These results suggest that the increases in skeletal muscle carnosine P < 0.05). These results suggest that the increases in skeletal muscle carnosine P concentration following sprint training may be associated with the increase in sustainability of high power during 30-s maximal cycle ergometer sprinting.

show abstract

Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle

Cited by 75 publications

References 28 publications

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats

Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

The Effect of Sprint Training on Skeletal Muscle Carnosine in Humans

Contact Info

Product

Resources

About