Effect of dietary Astragalus Polysaccharide supplements on testicular piRNA expression profiles of breeding cocks

Wu, Shengru; Li, Yulong; Chen, Si; Liang, Saisai; Ren, Xiaochun; Guo, Wei; Sun, Qingzhu; Yang, Xiaojun

doi:10.1016/j.ijbiomac.2017.05.122

Cited by 5 publications

(4 citation statements)

References 64 publications

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“…Astragalus polysaccharide (APS) is one of the main active ingredients in astragalus. It has been reported to have many pharmacological activities [ 20 – 23 ], such as immunity enhancement, anti-tumor, hypoglycemic, anti-oxidation, anti-inflammatory, anti-aging, and antiviral activities, and has a wide range of clinical applications. At present, the research and clinical application of APS has mostly focused on the regulation of immune function.…”

Section: Introductionmentioning

confidence: 99%

Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease

et al. 2018

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BackgroundAstragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking.Material/MethodsThe present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential.ResultsIt was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model.ConclusionsAPS provided a protective effect on neurons and mitochondrial in a mouse PD model.

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Section: Introductionmentioning

confidence: 99%

Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease

et al. 2018

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“…China. In recent years, studies have shown that APS have anti-stress, antioxidant, antiviral, and immune balance effects, and a number of studies have shown that APS can inhibit the expression of in ammatory factors and in ammatory damage [13][14], However, the use of APS for the prevention and treatment of urinary stula after hypospadias and the mechanism of urinary stula prevention and treatment have not been reported. Therefore, we selected APS for postoperative intervention in the hypospadias model of New Zealand male rabbits, and found that the incidence of urinary stula was signi cantly lower than that in the operation group after the addition of APS, and with the increase of the intervention dose of APS, the incidence of urinary stula after surgery decreased.…”

Section: Astragalus Polysaccharides(aps) Are One Of the Most Famous C...mentioning

confidence: 99%

Astragalus polysaccharide reduces the incidence of postoperative urethral fistula in the rabbit model of hypospadias

Shu

Liu

et al. 2023

Preprint

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Background Hypospadias is a common congenital malformation in pediatric urology. Surgery is the only treatment option for hypospadias, and urinary fistula is the most common complication after hypospadias repair. Purpose The purpose of this study was to establish a model of surgical hypospadias in New Zealand rabbits followed by TIP urethroplasty, postoperative administration of Astragalus polysaccharides (APS), and to study the effect and mechanism of APS on the prevention and treatment of urinary fistula after surgery. Material and Methods New Zealand male rabbits were randomly divided into 5 groups: Control group, was fed normal feed without surgery; The operation group, TIP was performed after the establishment of a surgical hypospadias model, and normal feed feeding was given after surgery. In the intervention groups, after the establishment of the surgical hypospadias model, TIP was performed, and the low dose of APS (100mg/kg), the medium dose (200mg/kg), and the high dose (300mg/kg) were mixed into feed feeding, and the urinary fistula rate was statistically calculated after 10 consecutive days of feeding. Results The incidence of urinary fistula was significantly lower than that in the surgical group after the addition of APS, and with the increase of the intervention dose of APS, the incidence of urinary fistula showed a decreasing trend. After removing penile tissue, HE examination and WB analysis were performed, compared with the control group, the urethral epithelial cells at the incision site of the operation group were loosely arranged, the layers were reduced, and the inflammatory cells were significantly increased. Compared with the operation group, the urethral epithelial cells at the incision site of the APS intervention group were closely arranged, the layers increased, the inflammatory cells were significantly reduced, and the number of new capillaries increased. In addition, compared with the operation group, the expression levels of TNF-a and NF-kb2 proteins in the intervention group were significantly reduced, and the levels of TGF-β1 and FGF-1 were significantly increased. Conclusion The intervention of APS can reduce local inflammatory response, enhance local fibrosis, and reduce the incidence of urinary fistula after hypospadias.

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“…The altered nutritional supplementation can be transferred to memory-like responses in the offspring through epigenetic mechanisms without changing DNA sequence ( Wu et al., 2019a , 2019b ). Nutrients that are effective in the regulation of the metabolism and immunity of animals include some functional nutrients and non-nutritional additives, such as amino acids ( Phang et al., 2013 ), vitamins ( Joubert et al., 2016 ), polysaccharides ( Wu et al., 2017 ), probiotics and prebiotics ( Kumar et al., 2013 ), which may be candidates for epigenetic regulation.…”

Section: Introductionmentioning

confidence: 99%

Paternal transgenerational nutritional epigenetic effect: A new insight into nutritional manipulation to reduce the use of antibiotics in animal feeding

Wang¹,

Liu²,

Chen³

et al. 2022

Animal Nutrition

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Effect of dietary Astragalus Polysaccharide supplements on testicular piRNA expression profiles of breeding cocks

Cited by 5 publications

References 64 publications

Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease

Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease

Astragalus polysaccharide reduces the incidence of postoperative urethral fistula in the rabbit model of hypospadias

Paternal transgenerational nutritional epigenetic effect: A new insight into nutritional manipulation to reduce the use of antibiotics in animal feeding

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