Effect of Dietary Antioxidants on Serum Lipid Contents and Immunoglobulin Productivity of Lymphocytes in Sprague-Dawley Rats

Tocotrienol Levels in Various Tissues of Sprague-Dawley Rats after Intragastric Administration of Tocotrienols

“…T3 have been reported to have antioxidative, [1][2][3] hypocholesterolemic, 4) and immunoregulatory activities. 5,6) It is important to elucidate the T3 distribution to know how T3 function. The T3 distribution in animal tissues has been reported in the plasma 4 hr after an oral administration of T3 to hamsters.…”

Dietary Effect of .ALPHA.-Tocopherol and Tocotrienols on Lipid Metabolism and Immune Function of Aged Sprague-Dawley Rats.

“…These results suggest that there is an upper limit in the regulatory activity of tocopherol derivatives on lipid metabolism. Kaku et al (1999) found that T3 significantly decreased serum triglyceride level, but the decrease in total cholesterol or triglyceride level was not significant in young rats. In addition, they reported that T3 exerted stronger effect on serum lipid levels than Toc in young SD rats, as observed here in aged rats.…”

“…They also reported that significant increases in IgA and IgG productivity were observed in MLN lymphocytes of rats fed T3, but not in those of rats fed ␣-Toc. Kaku et al (1999) found that in young SD rats fed ␣-Toc or T3 at the 0.1% level, a significant increase in serum IgA level was observed in the former animals, but the increase was not significant in the latter. They also reported that a significant increase of IgM productivity was observed in spleen lymphocytes and significant increases of IgA, IgG and IgM productivity in MLN lymphocytes isolated from rats fed T3, but the increase of Ig productivity in those fed ␣-Toc was detected only in IgA productivity of MLN.…”

“…Tocopherols (Toc) are the most popular natural antioxidants ubiquitously present in both the plant and animal kingdom, and tocotrienols (T3) are structural analogs of Toc with 3 double bonds in the side chain. These Toc and T3 derivatives have also been reported to express various biological effects, such as antioxidative (Kamat et al, 1997), anticancer (Rahmat et al, 1993, Makpol et al, 1997, hypocholesterolemic (Qureshi et al, 1991) and immunoregulatory activities Kaku et al, 1999).…”

“…It has been reported that various food components such as unsaturated fatty acids, antioxidants and dietary fibers affect the above immune functions (for review, see Yamada et al, 1999). It has also been reported that oral administration of Toc derivatives induces classspecific regulation of immunoglobulin (Ig) production, for instance, down-regulation of IgE production and up-regulation of IgA and IgG production (Gu et al, 1994Kaku et al, 1999). In addition, Toc derivatives exert an anti-allergic effect through the suppression of 4-series LT production (Gu et al, 1994;.…”