Recent topics in anti‐oxidative factors

Abstract

Lipids and anti-oxidative factors regulate immune functions such as immunoglobulin production and chemical mediator release. For example, polyunsaturated fatty acids (PUFA) enhance IgE production of isolated rat lymphocytes, but not in the presence of alpha-tocopherol. In addition, anti-oxidative factors such as tea polyphenols and flavonoids exert inhibitory effect on chemical mediator release from rat peritoneal exudate cells (PEC). Some of these immunoregulatory activities of food components could be expressed in vivo. Oral administrations of perilla and fish oils or tea polyphenols led to a significant decrease of LTB4 releasing activity of rat PEC, but IgE production enhancing activity of PUFA was not expressed in vivo. On the other hand, alpha-tocopherol feeding enhanced serum IgA level as well as IgA productivity of mesenteric lymph node lymphocytes. These results suggest that dietary fats and antioxidants are effective for the alleviation of allergic symptom and activation of immune functions.

Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells

“…Our results indicate that these phenolic compounds may not be the main anti-allergic active components in adlay bran (Table 3). However, it has been reported that there is no correlation between anti-allergic and anti-oxidative effects (Yamada and Tachibana, 2000). In addition, the complement activation pathway may serve as a central regulator of allergic disorders.…”

Plasma micronutrients are associated with dietary intake and environmental tobacco smoke exposure in a paediatric population

“…The tocopherols act as chain-breaking antioxidants that protect cell membranes from damage caused by lipid peroxidation and also inhibit cell proliferation, platelet adhesion and formation of N -nitroso compounds 4 , 5 . Both the carotenoids and tocopherols stimulate cell-mediated and humoral immunity 6 .…”

Effect of Polyphenols in Sea Buckthorn Berry on Chemical Mediator Release from Mast Cells

“…The polyphenols in SBB have been shown to be involved in its antioxidant activity ( Chen et al, 2007 , 2013 ). For example, epigallocatechin gallate, a polyphenol abundant in green tea, has shown antioxidant activity and strong antiallergic effects ( Yamada and Tachibana, 2000 ). Yamada et al (1999) reported that the antioxidant activity of phenolic compounds is involved in the inhibitory activity of LTB 4 production by mast cells.…”