Effect of dietary advanced glycation end-products restriction on type 2 diabetes mellitus control: a systematic review

Abstract

Context Reducing dietary advanced glycation end-products (AGEs) may favor diabetes control. Objective Critically analyze studies about the effect of dietary AGEs restriction on inflammation, oxidative stress, and glycemic control in patients with type 2 diabetes mellitus (DM2). Data Source This systematic review was conducted according to PRISMA methodology. The PubMed, Web of Science, LILACS, and Cochrane Library databases were searched, using the terms “type 2 diabetes,” “advanced glycation end products” and “diet.” Data Extraction Seven original studies were included in this review. The duration of the studies ranged from 1 day to 16 weeks. All extracted data were compiled, compared, and critically analyzed. Data Analysis Glycemic variables were considered the primary outcomes. The secondary outcomes were glycation, inflammatory, and oxidative stress markers. Conclusion Although serum insulin, homeostasis model assessment of insulin resistance, and glycated hemoglobin values were lower after the consumption of AGEs restricted diets in most studies, there was a lack of unanimity regarding dietary AGEs’ positive effect on inflammation, oxidative stress, and blood glucose. Systematic Review Registration PROSPERO registration no. CRD42020152640.

A non-invasive risk score including skin autofluorescence predicts diabetes risk in the general population

“…In animal studies exogenous AGEs are linked to reduced peripheral insulin responsiveness and involved in islet β-cell damage in both T1D and T2D 28 . However, the effect of dietary AGEs on insulin resistance in healthy volunteers is conflicting in small diet intervention trials 29 , 30 .…”

Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cytotoxicity of methylglyoxal in HepG2 cell line

“…AGEs heterogeneous compounds originate both endogenous and exogenously (G. Chen, 2021 , Oliveira et al, 2021 ) and are formed mainly from the reaction between the (di)carbonyl groups of reactive electrophilic species and the side chains of amino acid residues of proteins, mainly lysine and arginine (G. Chen, 2021 , Yeh et al, 2017 ). Among the different dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-dG), MGO is the most studied as it is one of the most cytotoxic and reactive compounds ( Huang, Chuang, Wu, & Yen, 2008 ).…”

“…Additionally, intake of exogenous MGO represents another important source. For example, the ingestion of natural plants subjected to severe stress, beverages and food products obtained by fermentation and thermally processed foods that might contain considerable amounts of MGO contribute to human exposure to this compound ( Oliveira et al, 2021 , Yeh et al, 2017 ). MGO is also present in the environment, for instance, in clouds, rainwater or cigarette smoke ( Jiang, Huang, Jiao, Bai, Zheng, & Ou, 2019 ).…”