Effect of dietary Acrocomia aculeata kernel oil rich in medium chain fatty acids on type 2 diabetic rats

Nunes, Ângela Alves; Buccini, Danieli Fernanda; Jaques, Jeandre Augusto dos Santos; Portugal, Luciane Candeloro; Guimarães, Rita Ca; Favaro, S. P.; Caldas, Ruy de Araujo; Carvalho, Cristiano Marcelo Espínola

doi:10.1016/j.jff.2020.104295

Cited by 10 publications

(9 citation statements)

References 52 publications

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“…The aqueous extract of A. aculeata (EA-Aa) is mainly composed by phenolic compounds and flavonoids, which are probably involved in the therapeutic effects of the extract. Similar data have already been described for the fruit pulp [ 23 ] and kernel of A. aculeata [ 24 , 25 , 26 ]. Plants of the same family, Arecaceae, have similar composition as EA-Aa, namely caffeic acid, rutin and quercetin [ 27 , 28 , 29 , 30 ].…”

Section: Discussionsupporting

confidence: 81%

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

et al. 2021

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Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese type 2 diabetic Goto–Kakizaki (GK-Ctrl) rats were treated for 30 days with 200 mg.kg−1 aqueous extract of Aa (EA-Aa) (Wistar, W-EA-Aa/GK, GK-EA-Aa). EA-Aa was able to reduce fasting glycaemia and triglycerides of GK-EA-Aa by improving proteins related to glucose and lipid metabolism, such as GLUT-4, PPARγ, AMPK, and IR, when compared to GK-Ctrl. It also improved viability of 3T3-L1 pre-adipocytes exposed by H2O2. EA-Aa also increased the levels of catalase in the aorta and kidney, reduced oxidative stress and increased relaxation of the aorta in GK-treated rats in relation to GK-Ctrl, in addition to the protective effect against oxidative stress in HMVec-D cells. We proved the direct antioxidant potential of the chemical compounds of EA-Aa, the increase in antioxidant defences in a tissue-specific manner and hypoglycaemic properties, improving vascular function in type 2 diabetes. EA-Aa and its constituents may have a therapeutic potential for the treatment of DM2 complications.

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Section: Discussionsupporting

confidence: 81%

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

et al. 2021

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“…All of these results indicated that the content of SCFAs and some of MCFAs was associated with T2DM. Previous studies proved that acetic acid, propionic acid, and butyric acid had beneficial influences on insulin secretion [46], and MCFAs might preserve pancreatic β‐cells function and improve their sensitivity [16]. In addition, the difference in the other SCFAs was also observed between rats with T2DM and the control group, which were less reported on account of their low content of SCFAs in the fecal sample.…”

Section: Resultsmentioning

confidence: 99%

“…There is an abundance of clinical and empirical studies proving that MCFAs modulated fat metabolism [12], glucose homeostasis [13], and hormone secretion involved in energy homeostasis [14]. On account of these biological functions, MCFAs have been deemed as a potential treatment for obesity [15], diabetes [16], Alzheimer's disease [17], and epilepsy [18]. Another study recognized that lauric acid can inhibit the proliferation of human hepatocellular [19], and cause apoptosis of cancer cells [20].…”

Section: Introductionmentioning

confidence: 99%

A pre‐column derivatization high‐performance liquid chromatography method for simultaneous determination of short‐chain and medium‐chain fatty acids in a fecal sample

Zhang

Zeng

et al. 2022

J of Separation Science

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Short‐chain and medium‐chain fatty acids have plentiful biological functions, which play a crucial role in the diagnosis and therapy of many diseases. Herein, a new method for simultaneous quantifying 17 short‐chain and medium‐chain fatty acids with high‐performance liquid chromatography coupled with an ultraviolet detector was developed and the pre‐column derivatization by indole‐3‐acetic acid hydrazide was performed to improve the separation and detection. The conditions of the derivatization reaction were systematically investigated. Subsequently, the method was validated and the results showed a satisfactory linearity (linear regression coefficients > 0.9969), the limit of detection (4.0×10−3–1.9×10−2 μmol/L), precision (0.9%–7.3% for intra‐day and 2.0%–9.8% for inter‐day), recovery (90.0%–109.1% with relative standard deviation <7.7%) and stability (0.1%–3.3% for standard solution and 0.2%–3.9% for fecal sample). Finally, the established method was successfully applied to quantify short‐chain and medium‐chain fatty acids in the feces of healthy control and diabetic rats. Eleven kinds of short‐chain and medium‐chain fatty acids were detected and six of them showed a significant difference between the control group and the model group.

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“…Still, on the biochemical parameters, a 28-day study with a different method, in which bocaiuva nut oil was added to the diet of rats previously induced to diabetes with a hyperlipidic diet plus streptozotocin, showed a decrease in LDL-c levels and an increase in HDL-c levels (Nunes et al, 2020), which could be a protective factor against the risk of atherosclerosis.…”

Section: 35mentioning

confidence: 99%

Bocaiuva (Acrocomia aculeata) nut oil: composition and metabolic impact in an experimental study

et al. 2023

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This study aimed to obtain physicochemical characteristics and the fatty acid profile of bocaiuva nut oil and to evaluate the impact of its daily consumption on glucose, lipid, and energy metabolism in mice. The acidity content in the bocaiuva nut oil exceeded the maximum limit for crude oils (5.68 mg KOH g -1 ). However, the peroxide value is within the standard considered adequate for crude oils (3.33 mEq O 2 kg -1 ). In the fatty acid profile, lauric (42.25%) and oleic (23.96%), saturated and monounsaturated, respectively, stand out. After 90 days of in vivo experimentation, the administered oil doses had not influenced the animals' food intake and body weight. Regarding the biochemical parameters, only the non-HDL fraction showed a significant difference, considering that this parameter represents the sum of atherogenic lipoproteins directly linked to atherogenic cholesterol. However, there was no statistical difference between the groups regarding histological changes in the liver, showing that the bocaiuva oil does not cause considerable damage to the liver, even though it is saturated oil. Results show that daily consumption of bocaiuva nut oil did not produce metabolic changes in mice.

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Effect of dietary Acrocomia aculeata kernel oil rich in medium chain fatty acids on type 2 diabetic rats

Cited by 10 publications

References 52 publications

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

A pre‐column derivatization high‐performance liquid chromatography method for simultaneous determination of short‐chain and medium‐chain fatty acids in a fecal sample

Bocaiuva (Acrocomia aculeata) nut oil: composition and metabolic impact in an experimental study

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