Effect of Dichlorvos on Histoarchitecture of The Cerebral Blood Vessels in Adult Wistar Rats

Abdu, Idris Tela; Adamu, Lawan Hassan; Modibbo, Musa Habibu; Yusuf, Abdullahi Asuku

doi:10.5455/jnbs.1444218339

Cited by 3 publications

(1 citation statement)

References 7 publications

(7 reference statements)

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“…Dichlorovos (2, 3-dichlorovinyldimethylphosphate) referred as organophosphates which belongs to insecticides. Therapeutically, dichlorovos is used as a fumigant and to treat a variety of parasitic worm infections in dogs, livestock and humans [7,8].…”

Section: Introductionmentioning

confidence: 99%

Studies on the Characterization of Esterase from Different Pisum sativum L. (Fabaceae) Varieties

Murthy¹,

Manjunath²,

Prakash³

et al. 2020

Rev. Chim.

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Pisum sativum L. (Fabaceae) is important in diet due to its fiber content, protein, starch, trace elements and phytochemical substances. Dichlorvos (2, 3-dichlorovinyl dimethyl phosphate) is commonly known as organophosphates belong to the classes of insecticides that are used to control households and stored products insects. The aim of this study was to analyze the kinetic characteristics of esterase enzyme from four different varieties of Pisum sativum L. using qualitative and quantitative method and also the docking position of esterase with Dichlorvos by insilico method. According to our study the total activity was highest for Arka Nirmala and Arka Priya varieties. The specific activity was highest for Arka Mayur variety. Km and Vmax, were found to be higher for Arka Uttam. The optimum temperature and pH for all the varieties were found to be same, 40�C and 7.5 respectively. The inhibitor studies showed Arka Nirmala was more sensitive to inhibitor. From the fitness and interaction profile it was found that the inhibitor dichlorovos is an effective pesticide which can be used to inhibit esterase activity. It has one hydrogen bond of H-S and had an amino acid residue at ARG57.

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Section: Introductionmentioning

confidence: 99%

Studies on the Characterization of Esterase from Different Pisum sativum L. (Fabaceae) Varieties

Murthy¹,

Manjunath²,

Prakash³

et al. 2020

Rev. Chim.

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The oral manifestations of Huntington's disease: A systematic review of prevalence

et al. 2021

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Objectives:The objective of this systematic literature review was to provide a complete panorama of the oral manifestations of Huntington's disease (HD). Materials and Methods:Databases were searched, and original research studies or case report manuscripts up to May 2021 were included using keywords that describe HD combined with words related to oral health; MeSH terms were used exclusively.No time or language restrictions were applied.Results: Twenty-two investigations (12 original articles and 10 case reports) regarding oral manifestations of HD were included. The subjects examined in the selected research articles were dental health, coordination of oral structures, speech, dysphagia, and swallowing alterations. The case reports described dental treatment procedures, oromandibular dyskinesia, dysphagia, and speech alterations. Conclusions:The oral manifestations of HD were found to be associated with the advance of the disease in that the more severe the HD, the worse the alterations affecting the oral cavity. Dysphagia, dysarthria, masticatory problems, oral health impairment, and choreiform movements involving the tongue and other orofacial muscles were the main manifestations of HD in the oral cavity. The PROSPERO systematic review registration number of this study is CRD42021238934.

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Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides.

Nwankwo

Uraku

Famurewa³

et al. 2018

Int J Med Surg Sci

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Although studies suggest adverse effects of pesticides, human exposure to insecticides in homes is increasing and reports on their health effects are limited. The study investigated nephrotoxic effects of organo phosphate and carbamate insecticides, DD-Force and Baygon, in albino rats. Forty-five albino rats divided into groups were exposed to DD-Force (dichlorvos) or Baygon (propoxur) indoor insecticidein wooden boxes in separate exposure duration of 1, 2, 3 and 4 hours/day for 14 consecutive days. Serum and kidney tissue obtained after sacrifice were used to determine markers of renal damage and histopathological analysis, respectively. Exposure of rats to the insecticides showed duration-dependent significant increases (p<0.05) in serum levels of urea, uric acid and creatinine compared to control. However, rats exposed to DD-Force insecticide induced significantly higher levels of urea, uric acid and creatinine compared to Baygon (p<0.05). Histopathological lesions were observed in rats exposed to the insecticides, particularly in the exposure duration of 3 or 4 hours/day. These findings suggest that acute exposure to DD-Force and Baygonis nephrotoxic and may induce renal damage in rats.

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Effect of Dichlorvos on Histoarchitecture of The Cerebral Blood Vessels in Adult Wistar Rats

Cited by 3 publications

References 7 publications

Studies on the Characterization of Esterase from Different Pisum sativum L. (Fabaceae) Varieties

Studies on the Characterization of Esterase from Different Pisum sativum L. (Fabaceae) Varieties

The oral manifestations of Huntington's disease: A systematic review of prevalence

Assessment of Nephrotoxicity and Histopathological Lesions of Albino Rats Exposure to DD-Force and Baygon Insecticides.

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