Effect of dialyzable leukocyte extract, sodium butyrate, and valproic acid in the development of anergy in murine leprosy

Rojas-Espinosa, O; Moreno-García, Sandra; Arce‐Paredes, Patricia; Becerril-Villanueva, Enrique; Juárez-Ortega, Mario

doi:10.4103/ijmy.ijmy_31_20

Cited by 3 publications

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“…Anergy in murine leprosy is a situation that can be variably reversed using immunomodulators such as dialyzable leukocyte extracts, omega 3 fatty acids, and sodium butyrate. [15,16] In the present study, the diminution in the number of Treg cells in the late states of the infection correlated with the decrease in the absolute numbers of T cells in the advanced stages of the disease (Figure 7).…”

Section: Discussionsupporting

confidence: 65%

"Regulatory T Cells (Treg) Participate in the Development of Anergy in Murine Leprosy"

Espinosa

2023

BJSTR

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Specific loss of cell-mediated immunity to Mycobacterium leprae, is a characteristic feature of human lepromatous leprosy. This phenomenon is called cellular anergy and it is considered the reason for the disease progression. It is not clear the reason for anergy in human leprosy, but several experimentalbased explanations have been proposed. One such explanation is the excess of suppression exerted by regulatory T cells (Treg). In murine leprosy, caused by Mycobacterium lepraemurium, cellular anergy is also observed and the model offers the opportunity to further explore the phenomenon vertically, in the same animal because of the availability of syngeneic strains, and during the whole time of infection. Syngeneic Balb/c mice were inoculated with MLM, and the evolution of the infection was monitored over 4 months based on diverse parameters: body weight, splenomegaly and hepatomegaly, presence of bacilli, and presence of CD4+CD25+Tbet and CD4+CD25+FoxP3 cells. It was found, by flow cell cytometry, that the first immune response in the infected animals reflected the activity of Th1 (Tbet+) cells and this response was then substituted by a predominant T-FoxP3 response, thus suggesting that CD4+CD25+FoxP3 cells play a role in the development of anergy in the malignant form of murine leprosy.

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Section: Discussionsupporting

confidence: 65%

"Regulatory T Cells (Treg) Participate in the Development of Anergy in Murine Leprosy"

Espinosa

2023

BJSTR

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“…For example, this occurs with VPA, sodium butyrate, and TSA. By downregulating cyclins A and D1 and upregulating P21, VPA could induce cell cycle arrest [ 67 ]. Additionally, sodium butyrate upregulated p21 and p27 protein expression [ 68 , 69 , 70 ].…”

Section: Inhibitors Of Histone Modificationmentioning

confidence: 99%

Polyphenols as Potent Epigenetics Agents for Cancer

Rajendran

Abdelsalam

Renu

et al. 2022

IJMS

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Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity.

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Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium

et al. 2022

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Effect of dialyzable leukocyte extract, sodium butyrate, and valproic acid in the development of anergy in murine leprosy

Cited by 3 publications

References 0 publications

"Regulatory T Cells (Treg) Participate in the Development of Anergy in Murine Leprosy"

"Regulatory T Cells (Treg) Participate in the Development of Anergy in Murine Leprosy"

Polyphenols as Potent Epigenetics Agents for Cancer

Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium

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