Polyphenols as Potent Epigenetics Agents for Cancer

Rajendran, Peramaiyan; Abdelsalam, Salaheldin A.; Renu, Kaviyarasi; Vishnupriya, V.; Ammar, Rebaï Ben; Ahmed, Emad A.

doi:10.3390/ijms231911712

Cited by 33 publications

(5 citation statements)

References 162 publications

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“…Polyphenols are very well-known antioxidants and thousands of scientific works have verified this activity for these ubiquitous natural compounds. A countless number of them, including many of those encountered in BP, have been conducted either at experimental or clinical levels, and have concerned many types of human diseases [ 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ]. The development of these studies being beyond the scope of our current paper, we will not develop these results here.…”

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“…This is consistent with the finding that in up to 70% of BC cases, a dysregulation of cellular processes such as autophagy has been reported to be associated with a reduced expression of autophagy-promoting proteins due to aberrant DNA methylation, leading to increased therapy resistance [79,80] (Figure 3). In order to specifically prevent tumorigenesis or reduce resistance to therapy, the TME (tumor microenvironment) therefore needs to be targeted, ideally with multitarget substances that attenuate the chronic inflammatory cascade at the epigenetic level [81,82]. An overview of other inflammatory cytokines and signaling pathways in association with BC is presented in Table 1.…”

Section: Breast Cancermentioning

confidence: 99%

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

Meyer,

Brockmueller,

Buhrmann

et al. 2024

Nutrients

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Breast cancer (BC) is currently one of the most common cancers in women worldwide with a rising tendency. Epigenetics, generally inherited variations in gene expression that occur independently of changes in DNA sequence, and their disruption could be one of the main causes of BC due to inflammatory processes often associated with different lifestyle habits. In particular, hormone therapies are often indicated for hormone-positive BC, which accounts for more than 50–80% of all BC subtypes. Although the cure rate in the early stage is more than 70%, serious negative side effects such as secondary osteoporosis (OP) due to induced estrogen deficiency and chemotherapy are increasingly reported. Approaches to the management of secondary OP in BC patients comprise adjunctive therapy with bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDs), and cortisone, which partially reduce bone resorption and musculoskeletal pain but which are not capable of stimulating the necessary intrinsic bone regeneration. Therefore, there is a great therapeutic need for novel multitarget treatment strategies for BC which hold back the risk of secondary OP. In this review, resveratrol, a multitargeting polyphenol that has been discussed as a phytoestrogen with anti-inflammatory and anti-tumor effects at the epigenetic level, is presented as a potential adjunct to both support BC therapy and prevent osteoporotic risks by positively promoting intrinsic regeneration. In this context, resveratrol is also known for its unique role as an epigenetic modifier in the regulation of essential signaling processes—both due to its catabolic effect on BC and its anabolic effect on bone tissue.

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“…It has been reported that RV can act epigenetically to modulate autophagy in cancer [ 22 - 24 ], and it is known that the secretions in the tumor microenvironment can epigenetically modulate autophagy to drive tumor dormancy [ 25 ]. In a separate study, we demonstrated that RV could keep ovarian cancer cells grown as 3D spheroids (a proxy of peritoneal metastatic colonies) in a dormant state even in the presence of IL-6, and this effect was due to the down-regulation of miR-1305 and concomitant re-expression of its target ARH-I (DIRAS3), which then rescued BECLIN-1-dependent autophagy [ 26 ].…”

Section: Main Subjectsmentioning

confidence: 99%

Resveratrol Promotes Self-digestion to Put Cancer to Sleep

Ferraresi,

Thongchot,

Isidoro

2024

J Cancer Prev

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Resveratrol, a natural polyphenol present in a variety of food stuff, has been shown to exert preventive and curative anticancer activity in several in vitro and in vivo models. Such chemopreventive/anticancer activity has been linked to biochemical and epigenetic modifications of multiple pathways involved in carcinogenesis and metastasization. In this commentary, we focus on the recent work done in our laboratory showing that resveratrol has potential to prevent and cure cancer by promoting epigenetic-mediated autophagy-dependent tumor dormancy, an effect associated with re-education of the cancer-associated fibroblasts and reduced production of inflammatory cytokines in the tumor microenvironment. The clinical translation of the current knowledge on resveratrol anticancer activity is also discussed.

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Polyphenols as Potent Epigenetics Agents for Cancer

Cited by 33 publications

References 162 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

Resveratrol Promotes Self-digestion to Put Cancer to Sleep

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