Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate-intrauterine insemination

Dickey, Richard P.; Taylor, Steven N.; Lu, Peter Y.; Sartor, Belinda M.; Rye, Phillip H.; Pyrzak, Roman

doi:10.1016/s0015-0282(02)04212-7

Cited by 134 publications

(101 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, we also observed that as the infertility duration became longer, the gestation rates also increased. However, in the literature, many studies have indicated that as the age (5,8,17) and infertility duration (7,17,18) increase, gestational rates decrease. Also, Ibérico et al (19) reported in a study published in 2004 that gestational rates in IUI decreased independently of the age through longer infertility durations.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Atasever¹,

Kalem²,

Hatırnaz³

et al. 2016

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Objective:The aim of the present retrospective study was to evaluate intrauterine insemination (IUI) clinical experiences and to define the variables for predicting success. Material and Methods:The present study was an observational trial performed in a private IVF center on subfertile couples who had applied for treatment between 2002 and 2012, in which the data of 503 IUI cases were retrospectively reviewed. Couples who had been diagnosed with unexplained and mild male subfertility were included. The primary outcome measure was the clinical pregnancy rate in an attempt to form a predictive model for the odds of a clinical pregnancy. Recorded parameters were used to determine the prediction model. Results:Utilizing univariate logistic regression analysis, clinical pregnancy was positively associated with the duration of infertility (OR=1.09, p=0.089), secondary infertility (OR=1.77, p=0.050), and +4 sperm motility after preparation (OR=1.03, p=0.091). Following an adjustment analysis involving a multivariate logistic regression, clinical pregnancy was still found to positively associate with secondary infertility (OR=2.51, p=0.008). Conclusion:IUI success in secondary infertile couples who were in the unexplained infertility and mild male subfertility groups was higher than that in primary infertile couples, and the chances of pregnancy increased as sperm numbers with +4 motility increased. It is difficult to concomitantly evaluate all these parameters and to determine a predictive parameter in IUI independent from other factors. (J Turk Ger Gynecol Assoc 2016; 17: 134-8) Keywords: Intrauterine insemination, unexplained infertility, male subfertility Received: 1 April, 2016 Accepted: 25 July, 2016 Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

show abstract

Section: Discussionmentioning

confidence: 99%

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Atasever¹,

Kalem²,

Hatırnaz³

et al. 2016

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

show abstract

“…The clinical pregnancy rate of AIH-IUI is approximately 10 % which is lower than that of in vitro fertilization and embryo transfer (IVF-ET). The pregnancy rate is associated with the woman's age, ovulation stimulations, time of insemination, frequency of insemination, semen quality, and the degree of tubal patency [Ibérico et al 2004;Dickey et al 2002]. However, injection of sufficient motile sperm into the uterine cavity is a key factor for successful IUI.…”

Section: Discussionmentioning

confidence: 99%

Relationship between processed total motile sperm count of husband or donor semen and pregnancy outcome following intrauterine insemination

Dong

Sun

et al. 2011

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

“…Dickey et al suggested that continuing CC-IUI for a fifth and sixth cycle might help to improve the outcome in older women, males with poor sperm quality, and women who respond to CC with fewer preovulatory follicles (5). Others have reported that the cumulative pregnancy rate plateaus by the ninth IUI cycle (16).…”

Section: Discussionmentioning

confidence: 99%

“…It can be performed efficiently in the office and does not require sophisticated equipment. Studies have confirmed its efficacy for specific indications including unexplained infertility, endometriosis, male infertility, and anovulation (1)(2)(3)(4)(5). Predictive sperm parameters and threshold values with respect to semen characteristics for successful intrauterine insemination have been controversial.…”

Section: Introductionmentioning

confidence: 99%

Impact of Semen Characteristics on the Success of Intrauterine Insemination

Zhao

Vlahos

Wyncott

et al. 2004

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose : To evaluate the influence of sperm characteristics on the outcome of infertility treatment using intrauterine insemination (IUI). Methods : Retrospective study of 431 infertility couples who underwent 1007 IUI treatment cycles from June 1999 to October 2002. Sperm parameters before and after preparation for IUI were evaluated and correlated with pregnancy outcome. Results : Clinical pregnancy occurred in 12% of cycles and 28% of patients. Initial sperm motility and processed forward progression were independently associated with pregnancy after IUI. The mean number of cycles per patient was 4.3. Although pregnancy rate per cycle did not differ from cycle to cycle, the cumulative pregnancy rate approached plateau after five cycles. Conclusions : Sperm motility is an independent factor influencing IUI-related pregnancy. A forward progression score of 3 to 4 in a processed specimen is necessary for IUI success. The number of IUI attempts per patient should be individualized depending upon the needs of patients.

show abstract

Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate-intrauterine insemination

Cited by 134 publications

References 17 publications

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Relationship between processed total motile sperm count of husband or donor semen and pregnancy outcome following intrauterine insemination

Impact of Semen Characteristics on the Success of Intrauterine Insemination

Contact Info

Product

Resources

About