Effect of DHEA on Recovery of Muscle Atrophy Induced by Parkinson's Disease

Choe, Myoung Ae; An, Gyeong Ju; Koo, Byung Soo; Jeon, Songhee

doi:10.4040/jkan.2011.41.6.834

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…There is also a known association between PD progression and decreased bone density (Handa et al, 2019). Consistent with these findings, our 6-OHDA treated rats reproduced the marked decreases in muscle mass and bodyweight (Kim and Choe, 2010;Choe et al, 2011Choe et al, , 2012Minalyan et al, 2019) as well as bone density (Ali et al, 2019;Handa et al, 2019) in neurotoxininduced PD animal model. Supplementation of the probiotic AP-32 prevented muscle atrophy, weight loss, and bone density deprivation, without affecting the food and water consumption behavior in the rats (Table 3).…”

Section: Discussionsupporting

confidence: 89%

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Nurrahma

Tsao

et al. 2021

Front. Aging Neurosci.

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Parkinson’s disease (PD) is a neurodegenerative disease associated with progressive impairment of motor and non-motor functions in aging people. Overwhelming evidence indicate that mitochondrial dysfunction is a central factor in PD pathophysiology, which impairs energy metabolism. While, several other studies have shown probiotic supplementations to improve host energy metabolism, alleviate the disease progression, prevent gut microbiota dysbiosis and alter commensal bacterial metabolites. But, whether probiotic and/or prebiotic supplementation can affect energy metabolism and cause the impediment of PD progression remains poorly characterized. Therefore, we investigated 8-weeks supplementation effects of probiotic [Lactobacillus salivarius subsp. salicinius AP-32 (AP-32)], residual medium (RM) obtained from the AP-32 culture medium, and combination of AP-32 and RM (A-RM) on unilateral 6-hydroxydopamine (6-OHDA)-induced PD rats. We found that AP-32, RM and A-RM supplementation induced neuroprotective effects on dopaminergic neurons along with improved motor functions in PD rats. These effects were accompanied by significant increases in mitochondrial activities in the brain and muscle, antioxidative enzymes level in serum, and altered SCFAs profile in fecal samples. Importantly, the AP-32 supplement restored muscle mass along with improved motor function in PD rats, and produced the best results among the supplements. Our results demonstrate that probiotic AP-32 and A-RM supplementations can recover energy metabolism via increasing SCFAs producing and mitochondria function. This restoring of mitochondrial function in the brain and muscles with improved energy metabolism might additionally be potentiated by ROS suppression by the elevated generation of antioxidants, and which finally leads to facilitated recovery of 6-OHDA-induced motor deficit. Taken together, this work demonstrates that probiotic AP-32 supplementation could be a potential candidate for alternate treatment strategy to avert PD progression.

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Section: Discussionsupporting

confidence: 89%

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Nurrahma

Tsao

et al. 2021

Front. Aging Neurosci.

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“…We believe that it is not accidental that SYNDIG1L and VRTN have been identified at the same time. SYNDIG1L is highly expressed in the striatum (de Chaldée et al, 2006). This is consistent with our previous RT-qPCR results.…”

Section: Discussionsupporting

confidence: 92%

“…As one of the basal ganglia of the brain, the striatum is mainly responsible for regulating muscle tension and coordinating various fine and complicated movements (Lorenc-Koci et al, 1998;Hemsley and Crocker, 2001). Meanwhile, it is related to the occurrence of Parkinson's disease (Miyanishi et al, 2019;Choe et al, 2011), chorea (Ishikawa et al, 1990, and other diseases. Correspondingly, some researchers found that the incidence of dyskinesia increased with the increase of thoracic vertebral numbers in pigs (Nakano et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Expression analysis and single-nucleotide polymorphisms of SYNDIG1L and UNC13C genes associated with thoracic vertebral numbers in sheep (Ovis aries)

et al. 2021

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Abstract. The objective of the current study was to analyze expression levels of synapse differentiation inducing 1-like (SYNDIG1L) and unc-13 homolog C (UNC13C) genes in different tissues, while single-nucleotide polymorphisms (SNPs) of two genes were associated with multiple thoracic vertebrae traits in both Small-tailed Han sheep (STH) and Sunite sheep (SNT). The expression levels of SYNDIG1L and UNC13C were analyzed in the brain, cerebellum, heart, liver, spleen, lung, kidney, adrenal gland, uterine horn, longissimus muscle, and abdominal adipose tissues of two sheep breeds with different thoracic vertebral number (TVN) sheep (T13 groups and T14 groups) by real-time quantitative polymerase chain reaction (RT-qPCR). Meanwhile, the polymorphisms of UNC13C gene g.52919279C>T and SYNDIG1L gene g.82573325C>A in T14 and T13 were genotyped by the Sequenom MassARRAY® SNP assay, and association analysis was performed with the TVN. The results demonstrated that UNC13C gene was extensively expressed in 11 tissues. The expression of UNC13C gene in longissimus muscle of T14 groups of STH was significantly higher than that of T13 groups (P<0.05). SYNDIG1L gene was overexpressed in brain and cerebellum tissues, and the expression level of UNC13C gene in the brain and cerebellum of T13 groups in SNT was significantly higher than that of T14 groups (P<0.01). Association analysis showed that SNPs found in the UNC13C gene had no significant effects on TVN for both two genes. The polymorphism of SYNDIG1L g.82573325C>A was significantly correlated with the TVN in both STH (P<0.05) and SNT (P<0.01). Taken together, the SYNDIG1L gene was related to thoracic vertebral development, and this variation may be potentially used as a molecular marker to select the multiple thoracic vertebrae in sheep.

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“…Additionally, the same group demonstrated that a single dose of DHEA administered to diabetic adult rats was able to increase Akt in skeletal muscle, which could act to improve the glucose metabolism [55]. Also, DHEA intervention in a rat Parkinson's disease model increased p-Akt and p-ERK in skeletal muscle [25]. A similar finding was reported by Ishizuka and cols (2007) [56] regarding DHEA activation of PI3K, among other kinases, in the adipose tissue and by Liu and cols (2008) regarding ERK 1/2 signaling pathway in bovine aortic endothelial cells [57].…”

Section: Discussionmentioning

confidence: 99%

“…This kinase was already shown to be activated by chronic DHEA-treatment as observed in heart tissue [22] and in Leydig cells by Ding and colleagues [23]. DHEA intervention has also demonstrated to upregulate Akt and other related pro-survival proteins in skeletal muscle in chronic disorders [24, 25]. Moreover, chronic DHEA administration affected steroid hormone levels and antioxidant parameters in different tissues of aged rats as well as induced a postponement of the aging process [26].…”

Section: Introductionmentioning

confidence: 99%

DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats

Jacob

Fernandes

Bonetto

et al. 2019

CAS

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Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern. We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 month-old rats). Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle. Gastrocnemius muscle was removed to evaluate glutathione system, hydrogen peroxide, antioxidant enzymes, and expression of Akt kinase protein. In the 3-month-old rats DHEA induced an increase in hydrogen peroxide when compared both to its control (276%) and the 24-month-old DHEA group (485%). Moreover, in the 24-month-old rats DHEA caused an increase in GSSG (41 and 28%), a decrease in reduced-GSH (55 and 51%), and a more oxidized redox status (reduction in GSH/GSSG ratio, 47 and 65 %) when compared to 3-month-old DHEA and to 24-month-old control groups, respectively. Both older groups had increased G6PDH (2.7 fold) and GST (1.7 fold) activities when compared to younger groups, independently of any DHEA treatment. However, there was no modulation of Akt protein (phosphorylated/total isoform). The results show that chronic DHEA administration to 3 and 24-month-old rats may not present positive effects regarding the redox environment in skeletal muscle without modulation of pro-survival Akt kinase. Due to the large-scale self-administration of DHEA as an "anti-aging" dietary supplement, it is crucial to investigate its molecular mechanisms over oxidative stress-induced related diseases.

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Effect of DHEA on Recovery of Muscle Atrophy Induced by Parkinson's Disease

Abstract: Our results suggest that DHEA treatment recovers Parkinson's disease induced contralateral soleus muscle atrophy through Akt and ERK phosphorylation.

Cited by 7 publications

References 31 publications

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Expression analysis and single-nucleotide polymorphisms of <i>SYNDIG1L</i> and <i>UNC13C</i> genes associated with thoracic vertebral numbers in sheep (<i>Ovis aries</i>)

DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats

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Effect of DHEA on Recovery of Muscle Atrophy Induced by Parkinson's Disease

Abstract: Our results suggest that DHEA treatment recovers Parkinson's disease induced contralateral soleus muscle atrophy through Akt and ERK phosphorylation.

Cited by 7 publications

References 31 publications

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism

Expression analysis and single-nucleotide polymorphisms of &lt;i&gt;SYNDIG1L&lt;/i&gt; and &lt;i&gt;UNC13C&lt;/i&gt; genes associated with thoracic vertebral numbers in sheep (&lt;i&gt;Ovis aries&lt;/i&gt;)

DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats

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Expression analysis and single-nucleotide polymorphisms of <i>SYNDIG1L</i> and <i>UNC13C</i> genes associated with thoracic vertebral numbers in sheep (<i>Ovis aries</i>)