Effect of dextran on patency of pericardial tubular graft of the superior vena cava in the dog

Brais, M.; Bertranou, Enrique G.; Brassard, André; Stanley, Paul; Chartrand, C

doi:10.1016/s0022-5223(19)40810-6

Cited by 15 publications

(2 citation statements)

References 18 publications

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“…To prevent thrombus formation, the major cause of failure of the microvascular anastomosis procedure, thrombolitic drugs such as warfarin, heparin, and direct thrombin inhibitors are widely used [8][9][10][11][12]. However, due to the risk for development of complications such as systemic hemorrhage, their clinical application may be restricted in patients with systemic disease and a bleeding tendency [5,13].…”

Section: Introductionmentioning

confidence: 99%

Effect of 4-hexylresorcinol on Blood Coagulation and Healing of Injured Vessel in a Rat Model

Park¹,

Park²,

Kim³

et al. 2013

The Journal Of Korean Association of Maxillofacial Plastic and

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Purpose: For reconstruction of craniomaxillofacial defects caused by tumor, trauma, infection etc, free flap transplantation with microvascular surgery is a very useful method. Thrombus formation at the anastomosis site is the major cause of graft failure. 4-Hexylresorcinol (4-HR) is generally known as an antiseptic and antiparasitic agent. This study was conducted in order to evaluate the effect of 4-HR on blood coagulation in vitro. In addition, we investigated thrombus formation and endothelial repair of an injured vessel in an animal model. Methods:In the in vitro experiment, we compared blood coagulation time between the 4-HR treated group and normal blood. Thirty rats were used for in vivo animal experiments. After exposure of the right femoral vein, a micro vessel clamp was placed and the femoral vein was intentionally cut. Microvascular anastomosis was performed on all rats using 10-0 nylon under microscopy. The animals were divided into two groups. In the experimental group (n=15), 4-HR (250 mg/kg) mixed with olive oil (10 mL/kg) was administered per os daily. Animals in the control group (n=15) were given olive oil only. The animals were sacrificed at three days, seven days, and fourteen days after surgery and rat femoral vein samples were taken. Vascular patency and thrombus formation were investigated just before sacrifice. Histologic analysis was performed under a microscope.Results: Results of an in vitro blood coagulation test showed that coagulation time was delayed in the 4-HR treated group. The results obtained from an in vivo 4-HR administered rat model showed that the patency of all experimental groups was better at thirty minutes, seven days, and fourteen days after microvascular anastomosis than that of the control group at seven and fourteen days after anastomosis, and the amount of thrombus in the experimental groups was much less than that of the control group. Endothelial repair was observed in the histologic analysis. Conclusion: Findings of this study demonstrated that blood coagulation was delayed in the vitro 4-HR treated group. In addition, good vascular patency, anti-thrombotic effect, and repair of venous endothelial cells were observed in the vivo 4-HR administered rat group.

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Section: Introductionmentioning

confidence: 99%

Effect of 4-hexylresorcinol on Blood Coagulation and Healing of Injured Vessel in a Rat Model

Park¹,

Park²,

Kim³

et al. 2013

The Journal Of Korean Association of Maxillofacial Plastic and

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“…15 Therefore, because the dog' s clinical signs were caused by obstruction of the vena cava and because of the adverse effects observed in dogs after ligation of the vena cava, an intraoperative decision was made to reconstruct the vessel. Several materials have been used for reconstruction of the cranial vena cava in research dogs, including autogenous external jugular vein, 16 pericardium, 17 autogenous small intestinal submucosa, 18,19 spiral-supported expanded polytetrafluoroethylene, 16,20,21 and fluorocarbon resin. 22 To the authors' knowledge, the only clinical report 12 of attempted vascular reconstruction of the cranial vena cava in a dog involved the insertion of a polytetrafluoroethylene vascular prosthesis, which subsequently became thrombosed.…”

mentioning

confidence: 99%

Use of a jugular vein autograft for reconstruction of the cranial vena cava in a dog with invasive thymoma and cranial vena cava syndrome

Holsworth¹,

Kyles²,

Bailiff³

et al. 2004

javma

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A spayed female dog was evaluated because of edema of the ventral cervical region, lethargy, cough, and reduced exercise tolerance. Invasive thymoma and cranial vena cava syndrome were diagnosed by use of ultrasound-guided fine-needle biopsy and contrast-enhanced helical computed tomography. Resection of the cranial vena cava and an autogenous jugular vein graft were used for restoration of normal venous return to the right atrium and alleviation of the cranial vena cava syndrome.

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Modified Blalock shunts utilizing pericardial tube grafts

Allen

Cole

1977

Journal of Pediatric Surgery

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Effect of dextran on patency of pericardial tubular graft of the superior vena cava in the dog

Cited by 15 publications

References 18 publications

Effect of 4-hexylresorcinol on Blood Coagulation and Healing of Injured Vessel in a Rat Model

Effect of 4-hexylresorcinol on Blood Coagulation and Healing of Injured Vessel in a Rat Model

Use of a jugular vein autograft for reconstruction of the cranial vena cava in a dog with invasive thymoma and cranial vena cava syndrome

Modified Blalock shunts utilizing pericardial tube grafts

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